Article
Clinical Neurology
Muriel Vicent-Gil, Sara Gonzalez-Simarro, Beatriz Raventos, Javier Vera, Eduardo D. Marin Martinez, Carlota Sabate-Cao, Josefina Perez-Blanco, Dolors Puigdemont, Javier de Diego-Adelino, Carlo Alemany, Maria Serra-Blasco, Narcis Cardoner, Maria J. Portella
Summary: This study aimed to investigate the impact of INCREM on psychosocial functioning and cognitive performance in clinically remitted depressed patients. The results showed significant improvements in psychosocial functioning and cognitive performance in the INCREM group, which were maintained six months later.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Anu Raevuori, Tero Vahlberg, Tellervo Korhonen, Outi Hilgert, Raija Aittakumpu-Hyden, Valerie Forman-Hoffman
Summary: The Meru Health Program did not show significant differences in depression outcomes compared to treatment as usual. However, the intervention group did show improvements in resilience, mindfulness, and reduction in perceived stress compared to the control group. Post-hoc analysis revealed a significant reduction in depression for patients on antidepressants receiving the intervention.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Matthew J. Knight, Ellen Lyrtzis, Celia Fourrier, Natalie Aboustate, Emma Sampson, Hikaru Hori, Micah Cearns, Julie Morgan, Catherine Toben, Bernhard T. Baune
Summary: The study aimed to evaluate an experimental treatment to improve psychosocial function in patients with Major Depressive Disorder by reinforcing cognitive, emotional, and social cognitive abilities. Findings demonstrate the efficacy of multi-domain cognitive training to improve psychosocial functioning in individuals with MDD.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Jeffry Florian, Rutger van der Schrier, Victoria Gershuny, Michael C. Davis, Celine Wang, Xiaomei Han, Keith Burkhart, Kristin Prentice, Aanchal Shah, Rebecca Racz, Vikram Patel, Murali Matta, Omnia A. Ismaiel, James Weaver, Rodney Boughner, Kevin Ford, Rodney Rouse, Marc Stone, Carlos Sanabria, Albert Dahan, David G. Strauss
Summary: This study aimed to investigate whether combining paroxetine or quetiapine with oxycodone would decrease the ventilatory response to hypercapnia, with findings showing that paroxetine plus oxycodone significantly decreased the ventilatory response on days 1 and 5, while quetiapine plus oxycodone did not have the same effect.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
Paul M. Cinciripini, George Kypriotakis, Charles Green, David Lawrence, Robert M. Anthenelli, Jennifer Minnix, Janice A. Blalock, Diane Beneventi, Chad Morris, Maher Karam-Hage
Summary: This study evaluated the safety and efficacy of smoking cessation pharmacotherapy among smokers with major depressive disorder (MDD). The results suggest that varenicline plus counseling may be the best pharmacological option for treating smoking in MDD smokers, including those with recurrent episodes, due to its higher efficacy effect size and similar risk of adverse events.
DEPRESSION AND ANXIETY
(2022)
Article
Medicine, General & Internal
M. Ishrat Husain, Imran B. Chaudhry, Ameer B. Khoso, Tayyeba Kiran, Nawaz Khan, Farooq Ahmad, John Hodsoll, M. Omair Husain, Haider A. Naqvi, Asad T. Nizami, Nasim Chaudhry, Hazrat A. Khan, Fareed Minhas, Jeffrey H. Meyer, Moin A. Ansari, Benoit H. Mulsant, Nusrat Husain, Allan H. Young
Summary: This study aimed to assess the efficacy and tolerability of adjunctive simvastatin in reducing depressive symptoms in treatment-resistant depression (TRD). The results showed no significant differences between the simvastatin group and the placebo group in primary and secondary outcomes, and there were also no significant differences in adverse effects between the two groups. Therefore, simvastatin did not provide additional therapeutic benefit for depressive symptoms in TRD.
Article
Clinical Neurology
Yuen-Siang Ang, Cristina Cusin, Yoann Petibon, Daniel G. Dillon, Micah Breiger, Emily L. Belleau, Marc Normandin, Hans Schroder, Sean Boyden, Emma Hayden, M. Taylor Levine, Aava Jahan, Ashley K. Meyer, Min Su Kang, Devon Brunner, Steven E. Gelda, Jacob Hooker, Georges El Fakhri, Maurizio Fava, Diego A. Pizzagalli
Summary: This study investigated option generation in major depressive disorder and how dopamine might modulate this process, as well as the effects of modafinil on option generation in healthy individuals. The findings showed that patients with major depressive disorder generated fewer but more unique options, and dopamine activity in the putamen played a key role in option generation. Modafinil was also found to reduce the creativity of options produced by healthy individuals.
Article
Medicine, General & Internal
Chunfeng Xiao, Jia Zhou, Anning Li, Ling Zhang, Xuequan Zhu, Jingjing Zhou, Yongdong Hu, Yunying Zheng, Jing Liu, Qiying Deng, Haibo Wang, Gang Wang
Summary: This non-profit randomized clinical trial found that a single subanesthetic dose of esketamine could enhance the efficacy of oral antidepressants in treating fluctuating antidepressant response, with a good safety profile.
Article
Psychiatry
Jingjing Zhou, Xiao Wang, Lei Feng, Le Xiao, Rui Yang, Xuequan Zhu, Hui Shi, Yongdong Hu, Runsen Chen, Philip Boyce, Gang Wang
Summary: The study aimed to compare the efficacy and safety of venlafaxine vs. fluoxetine in treating postmenopausal MDD. Results showed that venlafaxine was more effective than fluoxetine in the treatment of postmenopausal MDD in improving depressive symptoms.
Article
Psychiatry
Brandon M. Kitay, Eva Murphy, Matthew Macaluso, Philip R. Corlett, Rachel Hershenberg, Jutta Joormann, Valeria Martinez-Kaigi, Sina Nikayin, Taeho Greg Rhee, Gerard Sanacora, Richard C. Shelton, Michael E. Thase, Samuel T. Wilkinson
Summary: In this article, the study protocol for the CBT-ENDURE trial is described, aiming to explore the feasibility of cognitive behavioral therapy in relapse prevention for patients with depression and suicidal ideation following esketamine treatment. The trial will enroll 100 patients with clinically significant suicidal ideation and randomly assign them to receive CBT plus treatment as usual or treatment as usual only. This study is of significant importance in finding effective long-term treatment approaches.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Clinical
Marcelo T. Berlim, Stephane Richard-Devantoy, Nicole Rodrigues dos Santos, Gustavo Turecki
Summary: The study found that the psychopathological network structure of major depressive disorder changed after 8 weeks of antidepressant treatment, showing increased interconnectedness. Throughout the treatment process, the core symptoms of major depressive disorder include depressed mood, fatigue, and cognitive/psychomotor disturbance.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Victor W. Li, Emma Morton, Erin E. Michalak, Edwin M. Tam, Anthony J. Levitt, Robert D. Levitan, Amy Cheung, Rachel Morehouse, Rajamannar Ramasubbu, Lakshmi N. Yatham, Raymond W. Lam
Summary: The study found that light therapy significantly improved social and family functioning in patients with major depressive disorder, but did not significantly improve work functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Salman Zeb, Huan Ye, Yuan Liu, Hua-Ping Du, Yi Guo, Yong-Ming Zhu, Yong Ni, Hui-Ling Zhang, Yuan Xu
Summary: The decrease in astrocytes in depressive models may be caused by the activation of necroptotic kinases and astrocytic necroptosis. Treatment with fluoxetine inhibits the activation of receptor-interacting protein kinase 1 and improves depressive-like behaviors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Shuntaro Natsume, Hajime Baba, Hitoshi Maeshima, Takao Saida, Naoto Yoshinari, Kentaro Shimizu, Toshihito Suzuki
Summary: Depression is a risk factor for Alzheimer's disease, and changes in A13 protein metabolism may contribute to the transition from depression to AD. This study found that elderly patients with depression had decreased A1342 levels at admission, but these levels recovered to healthy levels 1 year after remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu, Shupeng Li
Summary: The study examined the involvement of HDAC1 and eEF2 in the antidepressant mechanisms of fluoxetine, showing that fluoxetine can alleviate LPS-induced depressive-like behaviors and neuroinflammation, while the HDAC1 activator Exifone reversed the antidepressant and anti-inflammatory effects of fluoxetine.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Mahsa Motamed, Hanieh Karimi, Hossein Sanjari Moghaddam, Sina Taherzadeh Boroujeni, Zahra Sanatian, Alireza Hasanzadeh, Mohammad-Reza Khodaei Ardakani, Shahin Akhondzadeh
Summary: This study aimed to investigate the efficacy and safety of adalimumab therapy in patients with chronic schizophrenia. The results showed that adalimumab adjunctive therapy was effective in improving negative and general psychopathology symptoms of schizophrenia, with no side effects. However, it did not significantly improve positive symptoms. There were no significant differences in inflammatory biomarker levels between the adalimumab and placebo groups.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Jerome Sarris, Arun Ravindran, Lakshmi N. Yatham, Wolfgang Marx, Julia J. Rucklidge, Roger S. McIntyre, Shahin Akhondzadeh, Francesco Benedetti, Constanza Caneo, Holger Cramer, Lachlan Cribb, Michael de Manincor, Olivia Dean, Andrea Camaz Deslandes, Marlene P. Freeman, Bangalore Gangadhar, Brian H. Harvey, Siegfried Kasper, James Lake, Adrian Lopresti, Lin Lu, Najwa-Joelle Metri, David Mischoulon, Chee H. Ng, Daisuke Nishi, Roja Rahimi, Soraya Seedat, Justin Sinclair, Kuan-Pin Su, Zhang-Jin Zhang, Michael Berk
Summary: The study aimed to provide definitive evidence-informed clinical guidelines for the use of nutrient-based 'nutraceuticals' and plant-based 'phytoceuticals' in treating major psychiatric disorders. These guidelines were developed by an international task force involving leading experts from 15 countries to assist clinicians in making informed decisions.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology
Maryam Maddineshat, Fatemeh Cheraghi, Ali Ghaleiha, Mitra Khalafbeigi, Efat Sadeghian
Summary: This study aimed to identify the facilitators and barriers of return to work (RTW) among working people with serious mental illness (WPSMI). The study found that emotional availability, information availability and use, practical assistance of others, employment facilitation by the society, and supervisor's flexibility were facilitators of RTW, while imposed effects of mental illness, poor self-concept, and social obstacles were identified as barriers.
INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
(2022)
Article
Substance Abuse
Mohammadali Nikoo, Kiana Kianpoor, Nooshin Nikoo, Sanam Javidanbardan, Alireza Kazemi, Fiona Choi, Marc Vogel, Ali Gholami, Saeed Tavakoli, James S. H. Wong, Ehsan Moazen-Zadeh, Reza Givaki, Majid Jazani, Fatemeh Mohammadian, Nader Markazi Moghaddam, Christian Schuetz, Kerry Jang, Shahin Akhondzadeh, Michael Krausz
Summary: This study aimed to compare the effectiveness of opium tincture (OT) and methadone in retaining participants in opioid agonist treatment (OAT). The results showed that OT retained 60% of participants to the end of the 85-day follow-up period and was superior to methadone in reducing self-reported opioid use outside of treatment. However, the study did not find sufficient evidence to conclude the non-inferiority of OT compared to methadone.
Article
Health Care Sciences & Services
Mahya Arayeshgari, Ghodratollah Roshanaei, Ali Ghaleiha, Jalal Poorolajal, Leili Tapak
Summary: This study used penalized count regression models to identify factors associated with the number of rehospitalizations of schizophrenia disorder. The results indicated that longer duration of illness, positive family history of psychiatric illness, having at least three children, unemployment/disability/retirement, residence in other townships, and a history of arrest/prison were significantly associated with an increase in the number of rehospitalizations.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Education & Educational Research
Amir Mohammad Salehi, Mahnaz Khatiban, Gita Sangestani, Seyedeh Zahra Masoumi, Ramin Kahaie, Ali Ghaleiha, Amin Biglarkhani, Koosha Ashtari
Summary: Electronic learning has significantly impacted continuing medical education, and this study aimed to design, install, and launch an electronic CME system to assess its effects on midwives' knowledge and problem-solving skills in postpartum hemorrhage (PPH). The results showed a significant improvement in the midwives' PPH knowledge and problem-solving skills, and a high satisfaction level with the electronic content and positive attitude toward e-CME.
EDUCATION RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Parnia Ebrahimi, Homa Seyedmirzaei, Kamyar Moradi, Sayna Bagheri, Mahdi Moeini, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
Summary: This study aimed to evaluate the therapeutic effects of cilostazol on aberrant behaviors in children with autism spectrum disorder (ASD) and its safety profile. A double-blind, randomized clinical trial was conducted with 66 confirmed ASD children. The results showed that cilostazol had beneficial effects on hyperactivity in children with ASD and higher levels of hyperactivity, with no significant adverse effects observed.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Letter
Clinical Neurology
Hossein Sanjari Moghaddam, Shahin Akhondzadeh
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Alireza Daneshvar, Mousa Golalizadeh
Summary: Quantile regression has received attention for its development in enriching regression models. This study proposes a new quantile regression model called 'lqsso-QR' that simultaneously performs estimation and variable selection tasks. Simulation studies demonstrate the superiority of this model, especially in terms of relative prediction error, compared to other penalties.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Article
Multidisciplinary Sciences
Alireza Daneshvar, Golalizadeh Mousa
Summary: In recent years, the state-of-the-art lasso and adaptive lasso techniques have gained significant attention. The adaptive lasso, unlike the traditional lasso, assigns adaptive weights to penalize coefficients in a different manner. However, the initial coefficient values less than one can lead to large weights and increased bias. To overcome this issue, a new weighted lasso method called 'lqsso' is proposed. The lqsso method takes into account both the signs and magnitudes of the initial coefficients to determine appropriate weights. Simulation studies demonstrate the superiority of the proposed methodology, particularly in high-dimensional settings, and an efficient algorithm for computation is provided. The application of the lqsso method is further illustrated using a real-world problem based on the rat eye dataset.
Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Psychiatry
Saeid Yazdi-Ravandi, Salman Khazaei, Hasan Davari, Nasrin Matinnia, Manochehr Karami, Zahra Taslimi, Mohammad Reza Afkhami, Ali Ghaleiha
Summary: The present study aimed to examine the relationship between suicide attempt, gender, and age. Data from the Hamadan Suicide Registry Program (2016-2017) were analyzed. Results showed that suicide attempts were less frequent among elderly patients. Elderly patients were more likely to use poison and self-immolation as means of attempted suicide. The rate of suicide attempts was higher in married females compared to males. Male suicide attempts peaked in autumn, while female suicide attempts peaked in summer. Females were more likely to use drugs, while males were more likely to engage in self-harm. Gender and age are important risk factors for suicide attempts.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Ahmad Shamabadi, Farnaz Kafi, Melika Arab Bafrani, Hassan Asadigandomani, Fatemeh A. Basti, Shahin Akhondzadeh
Summary: This study found that adjunctive L-theanine, when combined with sertraline, showed better efficacy in treating major depressive disorder (MDD) compared to placebo. The L-theanine group demonstrated significant improvement in depression symptoms and a greater reduction in depression scores compared to the placebo group at weeks 2, 4, and 6. Furthermore, the L-theanine group had higher remission and response rates at week 6. These findings suggest that L-theanine is a safe and effective adjunctive therapy for MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Sara Momtazmanesh, Sahar Ansari, Zahra Izadi, Parnian Shobeiri, Venus Vatankhah, Arash Seifi, Fereshteh Ghiasvand, Mahboobeh Bahrami, Mohammdreza Salehi, Ahmad Ali Noorbala, Shahin Akhondzadeh
Summary: This study investigates the efficacy and safety of famotidine in improving cognitive impairment, depression, and anxiety symptoms post-COVID-19. The results show that patients in the famotidine group had significantly higher MMSE and MoCA scores, as well as reduced HAM-D and HAM-A scores, compared to the placebo group. The study suggests that famotidine is safe and effective in treating cognitive impairment, depression, and anxiety symptoms induced by COVID-19.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Sophia Esalatmanesh, Ladan Kashani, Maryam Khooshideh, Hossein Sanjari Moghaddam, Sahar Ansari, Shahin Akhondzadeh
Summary: The study aimed to assess the effects of adjunctive celecoxib with cognitive behavioral therapy (CBT), an anti-inflammatory agent, in the treatment of postpartum depression. The results showed that adjunctive celecoxib is effective in improving postpartum depressive symptoms.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)