期刊
DEPRESSION AND ANXIETY
卷 26, 期 10, 页码 922-929出版社
WILEY-LISS
DOI: 10.1002/da.20532
关键词
panic disorder; Psychiatric Status Rating Scale; Panic Disorder Severity Scale; Clinical Global Impression Scale; equipercentile linking
资金
- National Institute of Mental Health [MH045963, MH045964, MH045965, MH045966]
- Asahi Kasei
- Astellas
- Dai-Nippon Sumitomo
- Eisai
- Eli Lilly
- GlaxoSmithKliine
- Janssen
- Kyowa Hakko
- Meiji
- Nikken Kagaku
- Organon
- Otsuka
- Pfizer
- Yoshitomi
- Forest
Background: The Panic Disorder Severity Scale (PDSS) is promising to be a standard global rating scale for panic disorder. In order for a clinical scale to be useful, we need a guideline for interpreting its scores and their changes, and for defining clinical change points such as response and remission. Methods: We used individual patient data from two large randomized controlled trials of panic disorder (total n = 568). Study participants were administered the PDSS and the Clinical Global Impression (CGI)-Severity and -Improvement. We applied equipercentile linking technique to draw correspondences between PDSS and CGI-Severity, numeric changes in PDSS and CGI-Improvement, and percent changes in PDSS and CGI-Improvement. Results: The interpretation of the PDSS total score differed according to the presence or absence of agoraphobia. When the patients were not agoraphobic, score ranges 0-1 corresponded with Normal, 2-5 with Borderline, 6-9 with Slightly ill, 10-13 with Moderately ill, and 14 and above with Markedly ill. When the patients were agoraphobic, score ranges 3-7 meant Borderline ill, 8-10 Slightly ill, 11-15 Moderately ill, and 16 and above Markedly ill. The relationship between PDSS change and CGI-Improvement was more linear when measured as percentile change than as numeric changes, and was indistinguishable for those with or without agoraphobia. The decrease by 75-100% was considered Very much improved, that by 40-74% Much improved, and that by 10-39% Minimally improved. Conclusion: We propose that remission of panic disorder be defined by PDSS scores of five or less and its response by 40% or greater reduction. Depression and Anxiety 26:922-929, 2009. (C) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据