Article
Chemistry, Physical
Jorge Luis da Silva Pires, Jorge Jose de Carvalho, Mario Jose dos Santos Pereira, Igor da Silva Brum, Ana Lucia Rosa Nascimento, Paulo Goncalo Pinto dos Santos, Lucio Frigo, Ricardo Guimaraes Fischer
Summary: This study compares the use of synthetic hydroxyapatite and xenograft for bone defects in rat calvaria, and found a significant enhancement in new bone matrix formation in groups using biomaterials compared to the control group. However, the addition of bone marrow mononuclear fraction did not further enhance the potential of hydroxyapatite-based biomaterials to induce bone matrix formation.
Article
Chemistry, Physical
Anna Bertran Faus, Jose Cordero Bayo, Eugenio Velasco-Ortega, Aina Torrejon-Moya, Francesca Fernandez-Velilla, Fernando Garcia, Jose Lopez-Lopez
Summary: This paper presents a case report on the use of customized titanium mesh for posterior vertical bone regeneration, demonstrating that this technique is feasible and predictable.
Article
Biochemistry & Molecular Biology
Tien-Ching Lee, Hui-Ting Chen, I-Chun Tai, Li-Ting Kao, Ming-Hsin Hung, Chung-Hwan Chen, Yin-Chih Fu, Yan-Hsiung Wang, Chih-Ming Kao, Je-Ken Chang, Mei-Ling Ho
Summary: The simvastatin derivative KMUHC-01 has been found to have a positive effect on promoting bone defect healing, with lower cytotoxicity compared to simvastatin. The new bone microstructure showed improved bone volume and biomechanical tests revealed increased maximal strength in the KMUHC-01 group. Further studies are needed to determine the bioavailability and bone-forming efficacy of KMUHC-01 through systemic administration.
Article
Biology
A. V. Shakurov, Yu. S. Lukina, A. S. Skriabin, L. L. Bionyshev-Abramov, N. B. Serejnikova, D. V. Smolencev
Summary: The aim of this study is to evaluate the effectiveness of bone defect cryostimulation in rats. The results show that cryotherapy twice a week can promote bone healing and maturation, filling the defect region effectively.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Chemistry, Physical
Marwa Y. Shaheen, Amani M. Basudan, Abdurahman A. Niazy, Jeroen J. J. P. van den Beucken, John A. Jansen, Hamdan S. Alghamdi
Summary: Inducing osteoporotic conditions in rat models negatively affected bone defect healing and xenograft material grafting, leading to reduced new bone formation, decreased remaining bone graft, and increased trabecular bone space.
Article
Veterinary Sciences
Radina Vasileva, Tzvetan Chaprazov
Summary: This study investigated the potential of erythropoietin to promote bone regeneration in a rat model. The results showed that applying erythropoietin locally on a collagen scaffold could induce bone healing, and combining it with a bone substitute resulted in faster integration between the xenograft and host bone.
VETERINARY SCIENCES
(2023)
Article
Chemistry, Physical
Francisco Correia, Daniel Humberto Pozza, Sonia Gouveia, Antonio Campos Felino, Ricardo Faria-Almeida
Summary: This study compared the performance of autologous bone grafts and porcine xenografts in maxillary sinus lift surgeries, showing no significant differences in bone level increases between the two materials. The porcine xenografts were found to be a reasonable alternative to autologous bone for sinus lift procedures.
Article
Multidisciplinary Sciences
Alexandru Petre, Cornel Balta, Hildegard Herman, Sami Gharbia, Ada Codreanu, Bianca Onita-Mladin, Nicoleta Anghel-Zurbau, Andrei-Gelu Hermenean, Simona-Rebeca Ignat, Sorina Dinescu, Iuliana Urzica, Sergiu Drafta, Luminita Oancea, Anca Hermenean
Summary: This study designed a new in vivo model to assess guided bone regeneration using a CAD-CAM space-maintaining barrier. The results obtained from the study show that the experimental model provides real-time information on bone tissue formation, depending on the volume of isolated space for GBR and molecular events that lead to satisfactory bone augmentation and osteointegration.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Engineering, Biomedical
Franz-Josef Strauss, Ulrike Kuchler, Reiko Kobatake, Patrick Heimel, Stefan Tangl, Reinhard Gruber
Summary: The study revealed that bone-derived growth factors contained in ABLs can attenuate bone regeneration within collagen membranes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Biochemistry & Molecular Biology
Reza Amid, Aida Kheiri, Lida Kheiri, Mahdi Kadkhodazadeh, Mehdi Ekhlasmandkermani
Summary: Xenograft bone substitutes from different species prepared by various methods are utilized widely due to their similarities to human bone. In vitro studies evaluating xenograft features in English language were systematically reviewed, showing a large heterogeneity in pore size and morphology. Proper porosity and pore connection were found to affect bone regeneration significantly.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yuichiro Ukon, Masahiro Nishida, Natsumi Yamamori, Kazuhiro Takeyama, Kazuhito Sakamoto, Shota Takenaka, Takahiro Makino, Takahito Fujimori, Yusuke Sakai, Yuya Kanie, Joe Kodama, Zeynep Bal, Daisuke Tateiwa, Shinichi Nakagawa, Hiromasa Hirai, Seiji Okada, Takashi Kaito
Summary: The EP4 agonist AKDS001 has the potential to enhance bone formation through minimodeling, as demonstrated in a rat heterotopic xenograft model and cultured human cells. AKDS001 promotes osteogenic differentiation and mineralization, inhibits bone resorption, and maintains the volume of grafted bone.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Erika B. S. Carvalho, Giovana F. Veronesi, Gustavo G. P. Manfredi, Carla A. Damante, Adriana C. P. Sant'Ana, Sebastiao L. A. Greghi, Mariana S. R. Zangrando, Alberto Consolaro, Maria L. R. Rezende
Summary: Bone demineralization with citric acid (CA) and tetracycline (TCN) can accelerate bone repair process and promote osteogenesis at the interface between bone grafts and receptor bone beds, especially when applied for 15 seconds and 60 seconds, respectively.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Biology
Jila Nasirzade, Karol Ali Apaza Alccayhuaman, Zahra Kargarpour, Ulrike Kuchler, Franz Josef Strauss, Layla Panahipour, Carina Kampleitner, Patrick Heimel, Frank Schwarz, Reinhard Gruber
Summary: The study found that dentin lysate coating did not significantly affect bone regeneration in rat calvarial defects, with nearly complete defect closure even in untreated defects. Therefore, conclusions cannot be drawn regarding the stimulation of bone regeneration by dentin lysates.
Article
Biotechnology & Applied Microbiology
Xiaoyu Wu, Su Ni, Ting Dai, Jingyan Li, Fang Shao, Chun Liu, Jiafeng Wang, Shijie Fan, Yadong Tan, Linxiang Zhang, Qiting Jiang, Hongbin Zhao
Summary: Researchers developed a PCL/Gelatin composite electrospun membrane with bubble-shaped nanofibrous structures, which improved biomineralization ability by increasing surface roughness and promoting mineralization. The membrane exhibited excellent cell compatibility and adhesion, and it effectively promoted vascularization and bone regeneration. The sustained-release of tetramethylpyrazine showed excellent drug release efficiency.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Veterinary Sciences
Tsvetan Chaprazov, Radina Vasileva, Kiril Atliev, Elena Firkova
Summary: This study compared the effects of local and systemic application of recombinant human erythropoietin (rhEPO) on the healing of rat calvarial defects. The results showed that local application of rhEPO enhanced bone formation without systemic effects, while systemic application affected erythropoiesis but did not result in bone formation.
VETERINARY SCIENCES
(2022)
