Review
Immunology
Shahram Solaymani-Mohammadi
Summary: Human giardiasis is a common parasitic disease that can lead to malnutrition and developmental disorders. Understanding the interaction between the parasite and the intestinal epithelial cells may provide insights into the pathology and help identify new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jingxia Gao, Guanzhong Song, Haibo Shen, Yiming Wu, Chongqi Zhao, Zhuo Zhang, Qian Jiang, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin
Summary: This study found that allicin improves intestinal barrier function and prevents damage caused by bacteria. It increases cell viability and enhances the integrity of cell monolayers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Luo, Shizhe Wu, Hai Jia, Xuemeng Si, Zhuan Song, Zhian Zhai, Jun Bai, Jun Li, Ying Yang, Zhenlong Wu
Summary: This study found that resveratrol pretreatment could protect porcine intestinal epithelial cells against damage caused by ETEC K88 infection by activating the SIRT-1 signaling pathway.
Article
Nutrition & Dietetics
Ya-Hui Yu, Xin-Huai Zhao
Summary: This study found that selenium-modified polysaccharides extracted from longan fruits can protect intestinal epithelial cells from food toxin-induced damage. The selenium-modified products showed better antioxidant and barrier-protective effects compared to the unmodified polysaccharides. Furthermore, increasing the degree of selenium modification enhanced the activity of the products.
Article
Biochemistry & Molecular Biology
Shuting Cao, Hao Xiao, Xin Li, Jiang Zhu, Jingchun Gao, Li Wang, Caihong Hu
Summary: The study demonstrates that oxidative stress leads to damage in intestinal barrier and mitochondrial function, while AMPK and PINK1/Parkin-mediated mitophagy plays a crucial role in alleviating this condition.
Article
Immunology
Wenjuan Xun, Qingyao Fu, Liguang Shi, Ting Cao, Hongzheng Jiang, Zhonghua Ma
Summary: The study demonstrated that resveratrol supplementation at 90 mg/kg effectively improved intestinal morphology, antioxidant capacity, and barrier function, while alleviating inflammation and oxidative stress in weaned piglets challenged with diquat. This effect was achieved through the activation of AhR/Nrf2 pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Jingwen Xie, Lin Liu, Hongyan Li, Hongxia Che, Wancui Xie
Summary: Oral administration of MSI significantly alleviated DSS-induced colitis by modulating inflammatory cytokines and oxidation stress, maintaining the mucosal barrier, and reverting microbiota changes.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Deborah Delbue, Lydia Lebenheim, Danielle Cardoso-Silva, Violaine Dony, Susanne M. Krug, Jan F. Richter, Subhakankha Manna, Melba Munoz, Kerstin Wolk, Claudia Heldt, Markus M. Heimesaat, Robert Sabat, Britta Siegmund, Michael Schumann
Summary: IL-22 impairs intestinal epithelial cell barrier by inducing EMT, causing defects in epithelial cell polarity and increasing cell motility and cell invasion. IL-22 modulates TJ protein expression and mediates tight junctional (TJal) barrier defects via ERK pathway.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jacob M. Allen, Amy R. Mackos, Robert M. Jaggers, Patricia C. Brewster, Mikaela Webb, Chia-Hao Lin, Chris Ladaika, Ronald Davies, Peter White, Brett R. Loman, Michael T. Bailey
Summary: Psychological stress alters the gut microbiota and increases the risk for enteric infections and chronic bowel conditions. Stress disrupts colonic epithelial cells and mucosal integrity, leading to dysbiosis in the gut microbiota.
Article
Biochemistry & Molecular Biology
Ying Li, Yudong Jiang, Lei Zhang, Wei Qian, Xiaohua Hou, Rong Lin
Summary: The study showed that exogenous l-fucose can protect intestinal barrier function and reduce the severity of colitis by increasing FUT2-mediated fucosylation of intestinal epithelial cells.
Article
Medicine, Research & Experimental
Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat
Summary: Acute and chronic intestinal inflammation can cause epithelial damage, and cells in the wound milieu secrete signaling molecules to influence repair. This study shows that BLT1, a receptor for lipid mediators, is expressed in intestinal epithelial cells and plays a role in promoting migration and proliferation of these cells during wound repair. In mouse models, the absence of BLT1 led to impaired intestinal wound healing. These findings reveal a novel mechanism involving BLT1 signaling in the repair of intestinal epithelial wounds.
Article
Pharmacology & Pharmacy
Xiaofan Song, Lei Qiao, Xina Dou, Jiajing Chang, Yafeng Zhang, Chunlan Xu
Summary: This study aimed to investigate the protective effect of selenium nanoparticles (SeNPs) against DON-induced intestinal epithelial barrier dysfunction and its relationship with the PERK-mediated signaling pathway. The results showed that SeNPs effectively alleviated DON-induced intestinal epithelial barrier dysfunction and were closely associated with the PERK signaling pathway.
Article
Biochemistry & Molecular Biology
Shaoying Gong, Jiachen Zheng, Junjie Zhang, Jianchun Han
Summary: This study investigated the effect of benzo[a]pyrene (B[a]P) on the function of intestinal epithelial barrier (IEB) and the protective effect of arabinogalactan (AG) against B[a]P-induced IEB dysfunction using a Caco-2 cell monolayer model. B[a]P was found to damage the IEB integrity by inducing cell cytotoxicity, oxidative stress, pro-inflammatory cytokine secretion, down-regulation of tight junction proteins, and activation of the AhR/MAPK signaling pathway. However, AG mitigated B[a]P-induced IEB dysfunction by inhibiting oxidative stress and pro-inflammatory factor secretion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yuhang Jin, Zhian Zhai, Hai Jia, Jinhua Lai, Xuemeng Si, Zhenlong Wu
Summary: Kaempferol can attenuate diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells by enhancing the expression of genes related to cell cycle progression and antioxidant system, increasing the abundance of tight junction proteins, and activating the antioxidant transcription factor Nrf2.
Article
Biochemistry & Molecular Biology
Wenjing Tao, Geng Wang, Xun Pei, Wanjing Sun, Minqi Wang
Summary: This study demonstrates that chitosan oligosaccharide (COS) has a protective effect against lipopolysaccharide (LPS)-induced intestinal injury. COS improves the mucosal morphology and tight junction protein expressions, increases goblet cells number and mucin expression, up-regulates antimicrobial peptide expressions, decreases pro-inflammatory cytokine production and neutrophil recruitment, and ameliorates intestinal oxidative stress. The beneficial effects of COS on intestinal barrier function are associated with its anti-inflammatory activities and antioxidant capacity.