期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 34, 期 1, 页码 61-67出版社
KARGER
DOI: 10.1159/000341576
关键词
Leukoaraiosis; Progression; Cerebrospinal fluid; Biomarkers; Oligodendrocyte; Myelin; Sulfatide
资金
- European Union [QLRT-2000-00446]
- Handlanden Hjalmar Svenssons Forskningsfond
- Pfannenstills Forskningsstiftelse
- The Alzheimer Research Fund
- Axel Linders Stiftelse
- The Foundation Gamla Tjanarinnor
- Sahlgrenska University Hospital
- Swedish Research Council
- Swedish Brain Power
- Stiftelsen Psykiatriska Forskningsfonden
Background/Aims: Demyelination and axonal degeneration are the hallmarks of established white matter lesions (WML). The neurochemistry of ongoing WML is only partially known. We explored cerebrospinal fluid (CSF) substances as markers of brain tissue damage in relation to progression of WML rated on magnetic resonance imaging. Methods: CSF from elderly individuals with WML was analyzed for amyloid markers, total tau, hyperphosphorylated t, neurofilament protein light subunit, sulfatide and CSF/serum-albumin ratio. After 3 years, a follow-up magnetic resonance imaging was performed. Progression of WML was rated using the Rotterdam Progression Scale (RPS). Results: 37 subjects (age 73.6 +/- 4.6 years) were included. Subjects with more pronounced progression (RPS > 2; n = 15) had lower mean sulfatide concentration at baseline as compared to subjects with no or minimal progression (RPS 0-2; n = 22) according to univariate analyses (p = 0.009). Sulfatide was the only biomarker that predicted the RPS score according to regression analysis, explaining 18.9% of the total variance (r = 0.38, p = 0.015). Conclusion: The correlation of CSF sulfatide levels and RPS scores may reflect a remyelination response to the demyelination process associated with WML. Furthermore, the results strengthen the notion that WML pathology is different from that of Alzheimer's disease. Copyright (C) 2012 S. Karger AG, Basel
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