Article
Immunology
Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi, Pengcheng Fan
Summary: This study analyzed the clinical and proteomic data of patients with Japanese encephalitis (JE) and identified two subtypes of JE with significantly different prognoses. The JE2 subtype was associated with a higher risk of cognitive impairment. The findings also provided potential target proteins for the treatment of cognitive impairments caused by JE.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Cell Biology
Amish Gaur, Luc Rivet, Ethan Mah, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Krista L. Lanctot
Summary: Mild cognitive impairment (MCI) is an early stage of dementia (such as Alzheimer's disease) that is accompanied by neurodegenerative signs. This study evaluated potential fluid biomarkers in MCI and found that elevated levels of NfL and GFAP can be detected in both cerebrospinal fluid (CSF) and peripheral blood. Monitoring these biomarkers may provide important insights into the underlying neurodegenerative processes in MCI.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Federico Paolini Paoletti, Lorenzo Gaetani, Giovanni Bellomo, Elena Chipi, Nicola Salvadori, Chiara Montanucci, Andrea Mancini, Marta Filidei, Pasquale Nigro, Simone Simoni, Nicola Tambasco, Massimiliano Di Filippo, Lucilla Parnetti
Summary: The pathophysiological processes and development of Parkinson's disease with mild cognitive impairment (PD-MCI) are still debated. This study investigated the CSF neurochemical profile and cognitive changes in PD-MCI, cognitively normal PD, prodromal Alzheimer's disease, and individuals with other neurological diseases. CSF biomarkers related to amyloidosis, tauopathy, neurodegeneration, synaptic damage, and glial activation were measured. The results showed that PD-MCI patients had higher levels of NfL/p-NfH ratio compared to PD-CN. Baseline levels of NfL, p-tau, and sTREM2 were associated with worsening cognitive impairment in PD-MCI after 2 years. Further investigations with larger cohorts and neuropathological verification are needed to understand the heterogeneity of PD-MCI.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Marcos Pais, Julia Loureiro, Vagner do Vale, Marcia Radanovic, Leda Talib, Florindo Stella, Orestes Forlenza
Summary: Analysis of CSF biomarkers was able to differentiate between AD, MCI, and NC, yet clinical-biological mismatches were observed in a non-negligible proportion of cases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Brenda Chino-Vilca, Inmaculada Concepcion Rodriguez-Rojo, Lucia Torres-Simon, Pablo Cuesta, Anna Carnes Vendrell, Gerard Pinol-Ripoll, Raquel Huerto, Nuria Tahan, Fernando Maestu
Summary: The study aims to evaluate the correlations between electroencephalography (EEG) and cerebrospinal fluid (CSF) markers in mild cognitive impairment (MCI) population. The findings indicate a negative correlation between A β-42 load and central-posterior theta power, as well as a negative correlation between t-tau and widespread alpha power in males. In females, there is a significant negative correlation between t-tau and widespread beta power.
CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Michelle M. Mielke, Jeremiah A. Aakre, Alicia Algeciras-Schimnich, Nicholas K. Proctor, Mary M. Machulda, Udo Eichenlaub, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Clifford R. Jack, Ronald C. Petersen, Jeffrey L. Dage
Summary: CSF phosphorylated tau 217 and p-tau181 have subtle differences in predicting Alzheimer's disease, CSF MSD p-tau181 and p-tau217 are associated with MCI risk among amyloid-positive individuals, and there are subtle differences in predicting cortical thickness.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, Research & Experimental
Aonan Zhao, Yang Jiao, Guanyu Ye, Wenyan Kang, Lan Tan, Yuanyuan Li, Yulei Deng, Jun Liu
Summary: This study found that sTREM2 may serve as a potential predictive biomarker of the conversion from MCI to AD. Low levels of CSF sTREM2 and Aβ1-42 were associated with an increased risk of MCI-to-AD conversion, while elevated CSF sTREM2 levels were associated with a decreased risk. In the NRHAD cohort, individuals in the MCI group with high plasma sTREM2 levels were more likely to progress to AD, and those with low Aβ1-42 and high plasma sTREM2 levels had a faster cognitive decline. CSF sTREM2 levels were highly correlated with plasma sTREM2 levels in the CABLE database.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Anna Dittrich, Nicholas J. J. Ashton, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Joel Simren, Tobias Skillback, Sara Shams, Alejandra Machado, Eric Westman, Michael Scholl, Ingmar Skoog, Silke Kern
Summary: This study investigates the relationship between chronic kidney disease (CKD) and neurodegenerative diseases. It shows that CKD patients have higher levels of plasma neurofilament light (P-NfL) compared to individuals with normal kidney function. Therefore, P-NfL may serve as a potential biomarker linking CKD to neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Yu-Wan Yang, Kai-Cheng Hsu, Cheng-Yu Wei, Ray-Chang Tzeng, Pai-Yi Chiu
Summary: The study operationalized the staging of cognitive impairment due to AD and non-AD using CDR-SB and an SCD questionnaire. Results showed that CDR-SB effectively discriminated between NC and SCD, SCD and MCI, and MCI and dementia. Importantly, CDR-SB was less influenced by age and education compared to other cognitive assessment tools.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Natalia Ogonowski, Stefanny Salcidua, Tomas Leon, Nayaret Chamorro-Veloso, Cristian Valls, Constanza Avalos, Alejandro Bisquertt, Miguel E. Renteria, Paulina Orellana, Claudia Duran-Aniotz
Summary: The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is high, making the diagnostic screening of MCI crucial. Currently, neuropsychological assessment tools are commonly used for MCI diagnosis, but new biomarkers are needed. miRNAs have emerged as promising biomarker candidates in peripheral fluids for early-stage AD, as they can regulate multiple signaling pathways. This systematic review aims to identify potential miRNA biomarkers for MCI and AD-related cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Elena Sagues-Sese, Jose Rioja, Francisco J. Garzon-Maldonado, Manuel Narvaez, Juan A. Garcia-Arnes, Natalia Garcia-Casares
Summary: This systematic review provides an overview of the state-of-the-art knowledge about insulin-related cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) and mild cognitive impairment (MCI). The results indicate decreased levels of CSF insulin and increased levels of insulin-related growth factors and their binding proteins.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Sindre Rolstad, Erik Palsson, Carl Johan Ekman, Elias Eriksson, Carl Sellgren, Mikael Landen
Article
Clinical Neurology
Sindre Rolstad, Joel Jakobsson, Carl Sellgren, Anniella Isgren, Carl Johan Ekman, Maria Bjerke, Kaj Blennow, Henrik Zetterberg, Erik Palsson, Mikael Landen
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Review
Endocrinology & Metabolism
Anders Wallin, Arto Nordlund, Michael Jonsson, Karin Lind, Ake Edman, Mattias Gothlin, Jacob Stalhammar, Marie Eckerstrom, Silke Kern, Anne Borjesson-Hanson, Marten Carlsson, Erik Olsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Annika Ohrfelt, Maria Bjerke, Sindre Rolstad, Carl Eckerstrom
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Review
Endocrinology & Metabolism
Anders Wallin, Arto Nordlund, Michael Jonsson, Kaj Blennow, Henrik Zetterberg, Annika Ohrfelt, Jacob Stalhammar, Marie Eckerstrom, Marten Carlsson, Erik Olsson, Mattias Gothlin, Johan Svensson, Sindre Rolstad, Carl Eckerstrom, Maria Bjerke
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Psychiatry
C. Abe, S. Rolstad, P. Petrovic, C. -J. Ekman, T. Sparding, M. Ingvar, M. Landen
ACTA PSYCHIATRICA SCANDINAVICA
(2018)
Article
Psychology, Clinical
Marie Eckerstrom, Johanna Skoogh, Sindre Rolstad, Mattias Gothlin, Gunnar Steineck, Boo Johansson, Anders Wallin
INTERNATIONAL PSYCHOGERIATRICS
(2013)
Article
Neurosciences
Sindre Rolstad, Anne Ingeborg Berg, Maria Bjerke, Boo Johansson, Henrik Zetterberg, Anders Wallin
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Clinical Neurology
Nora Balogh, Ragnar Astrand, Anders Wallin, Sindre Rolstad
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Geriatrics & Gerontology
Mattias Gothlin, Marie Eckerstrom, Sindre Rolstad, Anders Wallin, Arto Nordlund
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2017)
Article
Clinical Neurology
Erik Hessen, Marie Eckerstrom, Arto Nordlund, Ina Selseth Almdahl, Jacob Stalhammar, Maria Bjerke, Carl Eckerstrom, Mattias Gothlin, Tormod Fladby, Ivar Reinvang, Anders Wallin
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
(2017)
Article
Neurosciences
Erik Hessena, Arto Nordlund, Jacob Stalhammar, Marie Eckerstrom, Maria Bjerke, Carl Eckerstrom, Mattias Gothlin, Tormod Fladby, Ivar Reinvang, Anders Wallin
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Article
Neurosciences
Sindre Rolstad, Anne Ingeborg Berg, Carl Eckerstrom, Boo Johansson, Anders Wallin
JOURNAL OF ALZHEIMERS DISEASE
(2015)