期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 31, 期 4, 页码 247-253出版社
KARGER
DOI: 10.1159/000327171
关键词
Cerebrovascular disease; Stroke; Alzheimer's disease; Genetics
资金
- Alzheimer's Society [112]
- Henry Smith Charity
- Dunhill Medical Trust
- Alzheimer's Society (UK)
- Medical Research Council (UK)
- CADASIL Trust (UK)
- Alzheimer's Research Trust (UK)
- Newcastle NIHR Biomedical Research Centre in Ageing
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- MRC [G0900652, G0500247, G0400074, G0502157] Funding Source: UKRI
- Medical Research Council [G0500247, G0400074, G0502157, G0700718B, G0900652] Funding Source: researchfish
Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
