期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 30, 期 3, 页码 189-197出版社
KARGER
DOI: 10.1159/000313540
关键词
Mild cognitive impairment; Functional impairment; Activities of daily living; Memory performance; Executive function
资金
- National Institute on Aging [U01 AG016976, P50 AG16570]
- Alzheimer's Disease Research Centers of California
- Sidell-Kagan Foundation
- NATIONAL INSTITUTE ON AGING [P50AG016570, U01AG016976] Funding Source: NIH RePORTER
Background/Aims: Greater cognitive and functional deficits in mild cognitive impairment (MCI) are associated with higher rates of dementia. We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices. Methods: We analyzed data from 1,108 MCI and 3,036 normal control subjects included in the National Alzheimer's Coordinating Center Uniform Data Set who were assessed with the Functional Activities Questionnaire (FAQ). Results: IADL deficits were greater in amnestic than nonamnestic MCI, but within these subgroups, did not differ between those with single or multiple domains of cognitive impairment. FAQ indices correlated significantly with memory and processing speed/executive function. Conclusions: IADL deficits are present in both amnestic MCI and nonamnestic MCI but are not related to the number of impaired cognitive domains. These cross-sectional findings support previous longitudinal reports suggesting that cognitive and functional impairments in MCI may be independently associated with dementia risk. Copyright (C) 2010 S. Karger AG, Basel
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