期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 30, 期 3, 页码 229-237出版社
KARGER
DOI: 10.1159/000320136
关键词
Aging brain; Mild cognitive impairment; Alzheimer's disease; MR imaging; Apolipoprotein E genotype
资金
- EU [LSHB-CT-2005-518170]
- Health Research Council of the Academy of Finland [121038]
- Kuopio University Hospital [5772720]
- NIHR Biomedical Research Centre for Mental Health at the South London
- Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London
- Alzheimers Research UK [ART-RF2007-3] Funding Source: researchfish
Background: The protective effect of the apolipoprotein E (APOE) epsilon 2 allele against Alzheimer's disease (AD) is controversial. Objective: Our purpose was to clarify if the epsilon 2 allele affects regional cortical thicknesses and volumes. Methods: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. Results: In the mild cognitive impairment group, the epsilon 2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with epsilon 3/epsilon 3, and a larger cerebral gray matter and smaller lateral ventricles than the epsilon 3/epsilon 3 and epsilon 4 carriers. In the AD group, the epsilon 2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the epsilon 3/epsilon 3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than epsilon 4 carriers. No APOE2 effect was found in the control group. Conclusion: The APOE epsilon 2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. Copyright (C) 2010 S. Karger AG, Basel
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