期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 28, 期 3, 页码 252-258出版社
KARGER
DOI: 10.1159/000241878
关键词
Alzheimer's disease; Mini-Mental State Examination; Brain atrophy; Neuroimaging; Hippocampus
资金
- Norwegian Research Council [177404/W50, 175066/D15]
- University of Oslo
Background/Aims: Screening instruments such as the Mini-Mental State Examination (MMSE) are useful for the early identification of Alzheimer's disease ( AD). We tested whether macrostructural differences in brain volume are related to the MMSE. Methods: The MMSE was related to cortical thickness and the volume of 19 brain structures in 96 patients with mild to moderate AD. In addition, the patients were compared to 93 healthy elderly controls. Results: The MMSE was related to the volume of the total brain, cerebral cortex, accumbens, cerebral white matter, inferior lateral ventricles and hippocampus. Positive correlations with cortical thickness were found for 41% of the brain surface, and 58% of this area was significantly thinner in AD. Conclusion: The MMSE is sensitive to macrostructural brain atrophy in AD, but also to morphometric variation not specifically related to AD. Copyright (C) 2009 S. Karger AG, Basel
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