期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 25, 期 2, 页码 165-169出版社
KARGER
DOI: 10.1159/000112918
关键词
Alzheimer's disease; apolipoprotein E; beta-amyloid; beta-site amyloid precursor protein cleaving enzyme
Background: beta-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer's disease (AD) from its key role in beta-amyloid generation. Previous genetic association studies of BACE1 gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of BACE1 (rs638405, Val262) is associated with a risk for late-onset AD. Methods: We genotyped a synonymous C/G polymorphism of BACE1 located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. Results: The allele and genotype frequencies of BACE1 polymorphism were not significantly different between cases and controls (p > 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE-epsilon 4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319-3.018). Conclusion: These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE epsilon 4 allele. Copyright (C) 2008 S. Karger AG, Basel.
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