Article
Pharmacology & Pharmacy
Abdullah Glil Alkushi, Sara T. Elazab, Ahmed Abdelfattah-Hassan, Hala Mahfouz, Gamal A. Salem, Nagwa I. Sheraiba, Eman A. A. Mohamed, Mai S. Attia, Eman S. El-Shetry, Ayman A. Saleh, Naser A. ElSawy, Doaa Ibrahim
Summary: This study demonstrates that incorporating multi-strain probiotics into nanomaterials can enhance their therapeutic efficacy in treating inflammatory bowel disease. The use of nanomaterials as a carrier ensures the viability and targeted release of probiotics, leading to reduced colonic damage and improved intestinal epithelium healing. Additionally, the nanomaterial carrier promotes the restoration of beneficial gut microbiota.
Article
Agriculture, Multidisciplinary
Zhiyong Xie, Ziqi Zeng, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: The intracellular polysaccharides of Aspergilluscristatus (IPSs) from Fuzhuan brick tea have been found to improve immune function and modulate gut microbiota. In this study, it was demonstrated that the purified fraction of IPSs (IPSs-2) can protect against colitis in mice induced by dextran sulfate sodium (DSS) through various mechanisms, including reducing inflammation, repairing intestinal barrier function, and modulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ling Chen, Xiao-lin Zhong, Wen-yu Cao, Ming-li Mao, Dan-dan Liu, Wen-jia Liu, Xu-yu Zu, Jiang-hua Liu
Summary: In this study, the role and mechanism of IGF2 in ulcerative colitis were investigated using a mouse model. The results showed that IGF2 can alleviate colon injury and inflammation caused by ulcerative colitis by downregulating the cGAS-Sting pathway, thus maintaining colonic stemness and barrier integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. L. Zhu, X. W. Zhao, R. W. Han, Q. J. DU, Y. X. Qi, H. N. Jiang, D. W. Huang, Y. X. Yang
Summary: The study indicates that colostrum intake plays a crucial role in the colonization of intestinal microbiota and the expression of innate immune genes in newborn lambs, mainly by promoting the expression of antimicrobial peptides and tight junction proteins, which are essential for maintaining intestinal immune barrier.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Food Science & Technology
Hye-Jung Moon, Youn-Soo Cha, Kyung-Ah Kim
Summary: This study investigated the protective effects of blackcurrant (BC) on ulcerative colitis (UC) in mice. BC powder relieved symptoms of colitis, reduced the production of pro-inflammatory cytokines, regulated the NF-kappa B signaling pathway and gut barrier function related genes, and modulated the gut microbiota composition.
Article
Food Science & Technology
Geng Wang, Haidong Wang, Yuyue Jin, Zhiping Xiao, Yueying Lin, Haohan Chen, Minqi Wang, Muhammad Umar Yaqoob
Summary: The study demonstrates the protective effects of galactooligosaccharides (GOS) against LPS-induced intestinal barrier damages, showing increased expression of tight junction proteins, enhanced secretion of mucin and SIgA, alleviated inflammatory response, and promotion of specific friendly bacteria growth to improve intestinal microbiota adaptability.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Longxian Lv, Xiaoyuan Bian, Liya Yang, Jiafeng Xia, Xianwan Jiang, Wenrui Wu, Shuting Wang, Qiangqiang Wang, Lanjuan Li
Summary: Ketogenic diet worsens DSS-induced colitis in mice by increasing inflammation, disrupting the intestinal barrier, and modulating gut microbiota and metabolism.
Article
Agriculture, Multidisciplinary
Xin Li, Kaibin Mo, Ge Tian, Jiaxin Zhou, Jiongzhou Gong, Li Li, Xianhui Huang
Summary: This study investigated the effects of shikimic acid (SA) on intestinal inflammation using a mouse colitis model. The results showed that SA could slow down weight loss, reduce disease activity, enhance intestinal barrier function, inhibit key protein phosphorylation in MAPK and NF-kappa B signaling pathways, and decrease the expression of inflammatory factors. In addition, SA treatment altered the gut microbiota composition and richness. These findings suggest that SA has therapeutic potential in improving intestinal inflammation and enhancing intestinal immunity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xuan Wang, Hirokazu Fukui, Ying Ran, Xin Xu, Nobuhiko Ebisutani, Takashi Nakanishi, Yoshiki Tanaka, Ayako Maeda, Yutaka Makizaki, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa
Summary: This study found that oral administration of the probiotic Bifidobacterium bifidum G9-1 (BBG9-1) improved colonic mucosal integrity, reduced the increase of M1 macrophages, and decreased the expression of inflammatory cytokines IL-6 and IFN-gamma in maternally separated (MS) rats modeling irritable bowel syndrome (IBS).
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Food Science & Technology
Cong Zhao, Yu Jiang, Haixu Yin, Zhouyu Jin, Jing Yuan, Hongmei Shang, Hui Song
Summary: This study investigates the effect and possible mechanism of Hericium caput-medusae fermentation concentrate polysaccharide (HFP) on diarrhea in a mouse model of ulcerative colitis. The results show that HFP alleviated symptoms of ulcerative colitis in mice, including elevated body weight, increased colonic length and mucus layer thickness, and relief of diarrhea. HFP regulated the expression and activity of intestinal ion transport proteins, alleviated inflammation, reduced intestinal transit rate, and improved tight junction expression.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Bi-Ying Jin, Zhen Li, Ya-Nan Xia, Li-Xiang Li, Zi-Xiao Zhao, Xiao-Yu Li, Yan Li, Bing Li, Ru-Chen Zhou, Shi-Chen Fu, Shi-Yang Li, Yan-Qing Li
Summary: Delivery by cesarean section is associated with increased food allergies in a rat model, with higher responsiveness to allergens observed in CS-born rats. However, supplementation with probiotics containing Lactobacillus and Bifidobacterium can protect against allergic responses and indicate a dysbiosis of microbiota in CS-related allergies. This study suggests that interventions targeting microbiota composition in early life may be therapeutically relevant for CS-related food allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Juan Wang, Hui Zhao, Ke Lv, Wei Zhao, Ning Zhang, Fan Yang, Xiang Wen, Xiaohua Jiang, Jingrui Tian, Xinjuan Liu, Chi-Tang Ho, Shiming Li
Summary: Pterostilbene (PTE) protects intestinal epithelial barrier integrity through the NF-kappa B-MLCK/p-MLC signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Chiara Annunziata, Claudio Pirozzi, Adriano Lama, Martina Senzacqua, Federica Comella, Antonella Bordin, Anna Monnolo, Alessandra Pelagalli, Maria Carmela Ferrante, Maria Pina Mollica, Angelo Iossa, Elena De Falco, Giuseppina Mattace Raso, Saverio Cinti, Antonio Giordano, Rosaria Meli
Summary: The potential role of brown and beige adipose tissue against obesity has been recognized. Browning or beiging of white adipose tissue (WAT) is associated with the remodeling of adipocytes and the improvement of their metabolic and secretory functions. In this study, palmitoylethanolamide (PEA) was found to restore the plasticity of brown and white adipocytes impaired in mice on a high-fat diet (HFD). PEA promotes the beige-conversion of the subcutaneous WAT, increases thermogenic markers, and restores leptin signaling and tissue hormone sensitivity. The activation of peroxisome proliferator-activated receptor (PPAR)-alpha and AMPK phosphorylation play important roles in the effects of PEA.
Article
Biochemistry & Molecular Biology
Carmen Avagliano, Lorena Coretti, Adriano Lama, Claudio Pirozzi, Carmen De Caro, Davide De Biase, Luigia Turco, Maria Pina Mollica, Orlando Paciello, Antonio Calignano, Rosaria Meli, Francesca Lembo, Giuseppina Mattace Raso
Summary: Recent evidence suggests that the initiation of Parkinson's disease occurs in the gut as a prodromal phase of neurodegeneration. The impairment of gut function due to microbial dysbiosis might influence the pathogenesis and progression of Parkinson's disease. In this study, a two-hit model of Parkinson's disease was proposed, which involved dysbiosis and gut inflammation induced by ceftriaxone, followed by intrastriatal injection of 6-hydroxydopamine to mimic the dysfunctional gut-associated mechanisms preceding the onset of Parkinson's disease. The findings demonstrated that dysbiosis and gut damage exacerbated the progression of Parkinson's disease, leading to worsening motor deficits induced by 6-hydroxydopamine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
A. Lama, F. Del Piano, C. Annunziata, F. Comella, N. Opallo, S. Melini, L. Grumetto, C. Pirozzi, G. Mattace Raso, R. Meli, M. C. Ferrante
Summary: In this study, it was found that bisphenol A (BPA) exacerbates anxiety-like behavior induced by high-fat diet (HFD) in obese mice, and also increases neuroinflammation and immune activation. The results suggest that BPA represents an additional risk factor for mood disorders related to obesity, by enhancing HFD-induced neuroinflammation and immune activation.
Article
Biochemistry & Molecular Biology
Gina Cavaliere, Angela Catapano, Giovanna Trinchese, Fabiano Cimmino, Eduardo Penna, Amelia Pizzella, Claudia Cristiano, Adriano Lama, Marianna Crispino, Maria Pina Mollica
Summary: Neurodegenerative diseases (NDDs) are characterized by cognitive impairment and behavioural abnormalities. High-fat diets have been shown to cause mitochondrial dysfunction and affect synaptic plasticity, linking obesity and NDDs. Butyrate, a short-chain fatty acid, has been found to improve mitochondrial function and reduce neuroinflammation and oxidative stress in a mouse model of diet-induced obesity.
Article
Biochemistry & Molecular Biology
Luigia Turco, Nicola Opallo, Elisabetta Buommino, Carmen De Caro, Claudio Pirozzi, Giuseppina Mattace Raso, Francesca Lembo, Lorena Coretti
Summary: Gut dysbiosis is involved in Parkinson's disease, and the study on the dual-hit mouse model suggests that short-chain fatty acids metabolism and quorum sensing may be the underlying mechanisms linking gut dysbiosis to PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Filomena Del Piano, Adriano Lama, Giovanni Piccolo, Nicola Francesco Addeo, Doriana Iaccarino, Giovanna Fusco, Lorenzo Riccio, Davide De Biase, Giuseppina Mattace Raso, Rosaria Meli, Maria Carmela Ferrante
Summary: This study aimed to assess the effects of microplastics ingestion on gut innate immunity and barrier integrity in gilthead seabreams. The results showed that ingesting polystyrene microplastics can cause inflammation and immune alterations, as well as disrupt intestinal epithelial integrity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Agriculture, Dairy & Animal Science
Filomena Del Piano, Adriano Lama, Anna Monnolo, Claudio Pirozzi, Giovanni Piccolo, Simone Vozzo, Davide De Biase, Lorenzo Riccio, Giovanna Fusco, Raffaelina Mercogliano, Rosaria Meli, Maria Carmela Ferrante
Summary: Plastics are a major pollutant in the sea, breaking down into microplastic particles that can cause toxic effects in aquatic organisms. This study focused on the gilthead seabream and found that ingestion of microplastics increases oxidative and nitrosative stress in the intestine, impairing the antioxidant defense system. This damage to the gut can lead to health issues in fish.
Article
Chemistry, Analytical
Raffaele Simeoli, Sara Cairoli, Federica Galaverna, Marco Becilli, Emilia Boccieri, Giacomo Antonetti, Alessia Vitale, Alessandro Mancini, Chiara Rossi, Carlo Dionisi Vici, Bianca Maria Goffredo
Summary: This study demonstrates that VAMS and DPS can be used for therapeutic drug monitoring (TDM) of antifungal agents. The stability of these sampling devices allows for easy storage and shipping without refrigeration, making them suitable for remote TDM applications.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Infectious Diseases
Gabriella Bottari, Bianca Maria Goffredo, Marco Marano, Cristina Maccarrone, Raffaele Simeoli, Giuseppe Bianco, Leonardo Vallesi, Joseph Charles Charlie Beetham, Anna Teresa Mazzeo, Andrea Cappoli, Sara Cairoli, Raffaella Labbadia, Corrado Cecchetti, Paola Bernaschi, Tiziana Corsetti, Santo Morabito, Fabio Silvio Taccone, Isabella Guzzo
Summary: Extracorporeal therapies (ET) are increasingly used in pediatric settings as adjuvant therapeutic strategies for overwhelming inflammatory conditions. This prospective observational study demonstrated the different impact of CytoSorb (CS) and continuous kidney replacement therapy (CKRT) on the removal of antimicrobial drugs in critically ill children with sepsis/septic shock.
Article
Biochemistry & Molecular Biology
Licia Lugli, Elisabetta Garetti, Bianca Maria Goffredo, Francesco Candia, Sara Crestani, Caterina Spada, Isotta Guidotti, Luca Bedetti, Francesca Miselli, Elisa Muttini Della Casa, Maria Federica Roversi, Raffaele Simeoli, Sara Cairoli, Daniele Merazzi, Paola Lago, Lorenzo Iughetti, Alberto Berardi
Summary: This study aims to evaluate the pharmacokinetic characteristics of fentanyl in full-term newborns with hypoxic-ischemic encephalopathy (HIE) who have undergone therapeutic hypothermia (TH). By measuring fentanyl plasma concentrations, the study aims to optimize the dosing regimen of fentanyl during TH.
Meeting Abstract
Gastroenterology & Hepatology
Stefania Melini, Claudio Pirozzi, Adriano Lama, Filomena Del Piano, Federica Comella, Nicola Opallo, Chiara Annunziata, Giuseppina Mattace Raso, Rosaria Meli
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Claudio Pirozzi, Stefania Melini, Nicola Opallo, Adriano Lama, Filomena Del Piano, Federica Comella, Giuseppina Mattace Raso, Rosaria Meli
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
F. Comella, A. Lama, C. Pirozzi, S. Feijoo-Bandin, A. Aragon-Herrera, C. Annunziata, F. Del Piano, S. Morana-Fernandez, L. Anido-Valera, S. Melini, N. Opallo, R. Meli, G. Mattace Raso, J. R. Gonzalez-Juanatey, F. Lago Paz
EUROPEAN HEART JOURNAL
(2022)