☆ 4.6 Article

Maternal Protein Intake during Pregnancy Is Not Associated with Offspring Birth Weight in a Multiethnic Asian Population

JOURNAL OF NUTRITION (2015)

期刊

JOURNAL OF NUTRITION

卷 145, 期 6, 页码 1303-1310

出版社

OXFORD UNIV PRESS

DOI: 10.3945/jn.114.205948

关键词

pregnancy diet; macronutrients; protein; birth weight; birth length; ponderal index

类别

Nutrition & Dietetics

资金

Translational Clinical Research Flagship Program on Developmental Pathways to Metabolic Disease - National Research Foundation
Singapore Institute for Clinical Sciences
Agency for Science, Technology, and Research
Nestec
National Institute for Health Research through the National Institute for Health Research Southampton Biomedical Research Centre
MRC [MC_UP_A620_1017, MC_UU_12011/4] Funding Source: UKRI
Medical Research Council [MC_UP_A620_1017, MC_UU_12011/4] Funding Source: researchfish

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摘要

Background: Maternal diet during pregnancy can influence fetal growth. However, the relation between maternal macronutrient intake and birth size outcomes is less clear. Objective: We examined the associations between maternal macronutrient intake during pregnancy and infant birth size. Methods: Pregnant women (n = 835) from the Singapore GUSTO (Growing Up in Singapore Towards healthy Outcomes) mother offspring cohort were studied. At 26-28 wk of gestation, the macronutrient intake of women was ascertained with the use of 24 h dietary recalls and 3 d food diaries. Weight, length, and ponderal index of their offspring were measured at birth. Associations were assessed by substitution models with the use of multiple linear regressions. Results: Mean +/- SD maternal energy intake and percentage energy from protein, fat, and carbohydrates per day were 1903 +/- 576 kcal, 15.6% +/- 3.9%, 32.7% +/- 7.5%, and 51.6% +/- 8.7% respectively. With the use of adjusted models, no associations were observed for maternal macronutrient intake and birth weight. In male offspring, higher carbohydrate or fat intake with lower protein intake was associated with longer birth length (beta = 0.08 cm per percentage increment in carbohydrate; 95% CI: 0.04, 0.13; beta = 0.08 cm per percentage increment in fat; 95% CI: 0.02, 0.13) and lower ponderal index (beta = -0.12 kg/m(3) per percentage increment in carbohydrate; 95% CI: -0.19, -0.05; beta = -0.08 kg/m(3) per percentage increment in fat; 95% CI: -0.16, -0.003), but this was not observed in female offspring (P-interaction < 0.01). Conclusions: Maternal macronutrient intake during pregnancy was not associated with infant birth weight. Lower maternal protein intake was significantly associated with longer birth length and lower ponderal index in male but not female offspring. However, this finding warrants further confirmation in independent studies. This trial was registered at clinicaltrials.gov as NCT01174875.

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Circulating Insulin and IGF-1 and Frequency of Food Consumption during Pregnancy as Predictors of Birth Weight and Length

Dominika Mazurkiewicz, Monika Bronkowska

Summary: The study focused on assessing the relationships between maternal insulin and IGF-1 concentration, food consumption frequency, and newborn birth parameters. It found that frequent consumption of sweet and salty snacks, as well as fruit and fruit or vegetable juices, may lead to greater weight gain in pregnancy and higher newborn birth weight. Additionally, the study showed that overweight women had higher insulin concentrations and women over 35 years old had lower concentrations of IGF-1.

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