期刊
DALTON TRANSACTIONS
卷 47, 期 39, 页码 13861-13869出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8dt03160f
关键词
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资金
- CONICYT [21130725]
- project POSTDOC_DICYT, Vicerrectoria de Investigacion, Desarrollo e Innovacion of Universidad de Santiago de Chile [021841MC]
- Fondo de Desarrollo Cientifico y Tecnologico (FONDECYT), Chile [1151156, 1161375]
- NLHPC [ECM-02]
- Fondecyt Postdoctorado [3160431]
Cyrhetrenyl aldehyde derivatives [((5)-C5H4CHO)Re(CO)(2)PR3] with R = methyl (Me, 2a), phenyl (Ph, 2b), and cyclohexyl (Cy, 2c) were synthesized by a photochemical reaction from the starting material [((5)-C5H4CHO)Re(CO)(3)] (1) and the corresponding phosphines. The complexes were fully characterized by FT-IR, H-1, C-13 and P-31 NMR spectroscopy, elemental analysis and mass spectrometry. The molecular structures of 2a-c have also been determined. Electronic structure calculations by TD-DFT and electrochemical studies are in sound agreement with the effect of the substitution of one carbonyl group by a phosphine ligand. Additionally, the antiproliferative activity of complexes 1 and 2a-c was studied on the human cancer cell lines HT-29 and PT-45 using an MTT assay. Out of all new compounds, only the triphenylphosphine derivative 2b exhibited pronounced cytotoxic effects on both cell lines, being ca. 1.5 times more potent than cisplatin.
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