Article
Nanoscience & Nanotechnology
Najim Akhtar, Pei-Wen Wu, Chuan Lin Chen, Wen-Yi Chang, Ren-Shyan Liu, Chien Ting Wu, Agnishwar Girigoswami, Surojit Chattopadhyay
Summary: In this study, a pentamodal imaging agent with synergistic dual-targeting ability was developed. The agent used upconverting nanoparticles and transferrin protein conjugation to achieve passive and active targeting of cancer cells. The agent showed high efficiency and stability in radiolabeling, and demonstrated minimal cytotoxicity. In vivo studies confirmed the ideal bioavailability and renal clearance behavior of the agent, and multimodal tumor imaging demonstrated its potential as a single replacement for multiple imaging agents.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Adamantia Apostolopoulou, Aristeidis Chiotellis, Evangelia-Alexandra Salvanou, Konstantina Makrypidi, Charalampos Tsoukalas, Fotis Kapiris, Maria Paravatou-Petsotas, Minas Papadopoulos, Ioannis C. Pirmettis, Przemyslaw Kozminski, Penelope Bouziotis
Summary: This study successfully developed four new Au nanoconjugates radiolabeled with technetium-99m via thiol-bearing ligands attached to the NP surface. The functionalized AuNPs showed excellent in vitro stability and high radiochemical purity, demonstrating their potential application in multimodality imaging or in vivo tracking of drug-carrying AuNPs.
Article
Pharmacology & Pharmacy
Jiali Gong, Lingzhou Zhao, Jiqin Yang, Meilin Zhu, Jinhua Zhao
Summary: In this study, a [Tc-99m]Tc-labeled plectin-targeted peptide (PTP) was developed as a novel SPECT probe for tumor imaging. The PTP showed good biocompatibility and targeting ability to tumor cells in vitro. It could be readily labeled with [Tc-99m]Tc and exhibited high radiochemical purity and excellent stability. Furthermore, [Tc-99m]Tc-HYNIC-PTP showed favorable biodistribution, fast blood clearance, and clear accumulation in different types of tumors, with a good correlation between tumor uptake and plectin expression levels.
Article
Oncology
Xuran Zhang, Qing Ruan, Yuhao Jiang, Qianqian Gan, Junbo Zhang
Summary: The study evaluated the potential of Tc-99m-CN5DG as a broad-spectrum SPECT probe for tumor imaging in different tumor models. Results showed high accumulation of Tc-99m-CN5DG in tumors and kidneys, with high tumor/muscle and tumor/blood ratios. SPECT/CT images clearly showed all four types of tumors, indicating the potential clinical application of Tc-99m-CN5DG in tumor imaging.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Solene Marie, Irene Hernandez-Lozano, Louise Breuil, Charles Truillet, Shuiying Hu, Alex Sparreboom, Nicolas Tournier, Oliver Langer
Summary: The study revealed a significant decrease in hepatic uptake of [C-11]erlotinib in the new Slco2b1(-/-) mouse model, indicating a potential role of OATP2B1 in hepatic uptake of [C-11]erlotinib. However, the reduced hepatic uptake of OATP1B1/1B3 substrate [Tc-99m]mebrofenin in Slco2b1(-/-) mice raises questions about the assessment of the relative contribution of OATP2B1 for drugs that are substrates of multiple OATPs.
Article
Chemistry, Inorganic & Nuclear
Subhajit Ghosh, Shishu K. Suman, Haladhar D. Sarma, Tapas Das
Summary: Acridine or its derivatives have the potential to accumulate in tumors for diagnostic purposes. Tc-99m-labeled acridine showed significant accumulation and retention in tumors in in-vivo studies, indicating imaging potential for tumor lesions.
Article
Chemistry, Medicinal
Paola Vallejo-Armenta, Guillermina Ferro-Flores, Clara Santos-Cuevas, Francisco Osvaldo Garcia-Perez, Pamela Casanova-Trivino, Bayron Sandoval-Bonilla, Blanca Ocampo-Garcia, Erika Azorin-Vega, Myrna Luna-Gutierrez
Summary: This study evaluated the application of [Tc-99m]Tc-iFAP for tumor stroma imaging in six different cancer types and analyzed them from the perspective of stromal heterogeneity. The results showed that [Tc-99m]Tc-iFAP has potential for prognostic assessment of some solid tumors, particularly breast cancer.
Article
Biochemistry & Molecular Biology
Keresztely Merkel, David Szollosi, Ildiko Horvath, Balint Jezso, Zsolt Baranyai, Krisztian Szigeti, Zoltan Varga, Imre Hegedus, Parasuraman Padmanabhan, Balazs Gulyas, Ralf Bergmann, Domokos Mathe
Summary: This study reports a new method for labeling platelets using the peptide duramycin, allowing for efficient tracking of platelet biodistribution in vivo using single photon emission tomography (SPECT), and obtaining quantitative biodistribution images.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yujing Du, Zhao Chen, Ping Yan, Chunli Zhang, Xiaojiang Duan, Xueqi Chen, Meng Liu, Lei Kang, Xing Yang, Yan Fan, Jianhua Zhang, Rongfu Wang
Summary: The study identified heat shock protein 70 (HSP70) as the binding target for RRL, revealing a potential interaction between RRL and the nucleotide-binding domain (NBD) of HSP70. Clathrin-dependent endocytosis and macropinocytosis were suggested as vital internalization mechanisms of RRL. In vivo, Tc-99m-MAG3-RRL demonstrated satisfactory tumor accumulation and targeting, providing a promising probe for visualizing overexpressed HSP70 tumor sections.
MOLECULAR PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Jacqueline Bijnens, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, Frank De Geeter
Summary: This study retrospectively evaluated the ability of preoperative imaging modalities to localize parathyroid adenomas and found that F-18-fluorocholine-PET/CT is highly accurate in this regard. It showed that F-18-fluorocholine-PET/CT can obviate the need for total exploration in patients with discordant or negative ultrasound and scintigraphic results.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Hu Song, Guanquan Wang, Jing Wang, Xia Yang, Hongyuan Wei, Shunzhong Luo
Summary: TTHMP has been found to have good bone-seeking ability in previous studies. In this research, [Tc-99m]Tc-TTHMP was prepared and evaluated for its potential application in skeletal system imaging. Corresponding TTHMP kits were also developed. The biodistribution data showed high uptake of [Tc-99m]Tc-TTHMP in the bone and rapid excretion through the urinary system. Micro-SPECT/CT imaging in normal mice and SPECT imaging in a normal Beagle dog confirmed the results. It is suggested that [Tc-99m]Tc-TTHMP can be a candidate for skeletal system imaging.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Luis Coria-Dominguez, Paola Vallejo-Armenta, Myrna Luna-Gutierrez, Blanca Ocampo-Garcia, Brenda Gibbens-Bandala, Francisco Garcia-Perez, Gerardo Ramirez-Nava, Clara Santos-Cuevas, Guillermina Ferro-Flores
Summary: This study evaluated the kinetic and dosimetric profile of [Tc-99m]Tc-iFAP in healthy volunteers and assessed its uptake in different solid tumors in cancer patients. The results showed favorable biodistribution and kinetics of [Tc-99m]Tc-iFAP, with high uptake in primary tumor lesions and lymph node metastases. This validates its potential utility in the diagnosis and prognosis of different types of solid tumors.
Article
Chemistry, Analytical
Ugur Avcibasi, Taner Turkyarar, Aysegul Karadag, Buket Bakan, Nefise Ulku Karabay Yavasoglu, Kevser Kusat, Sinan Akgol, Derya Gulcemal, Volkan Tekin, Fazilet Zumrut Biber Muftuler, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser
Summary: The study aimed to synthesize a novel Tc-99m-labeled graft polymer and evaluate its properties in vitro and in vivo. The labeled compound showed high radiochemical yield and non-toxic characteristics in cytotoxicity and hemolysis tests. Biodistribution studies in healthy rats demonstrated high accumulation of the polymer in the pancreas, thyroid, and prostate.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Olga Bragina, Vladimir Chernov, Mariia Larkina, Anstasiya Rybina, Roman Zelchan, Eugeniy Garbukov, Maryam Oroujeni, Annika Loftenius, Anna Orlova, Jens Soerensen, Fredrik Y. Frejd, Vladimir Tolmachev
Summary: The determination of tumor HER2 status is crucial for HER2-targeted treatments. This study evaluated the safety and dosimetry of Tc-99m-ZHER2:41071 Affibody molecule for SPECT/CT imaging of HER2 expression. The results showed that the injection of Tc-99m-ZHER2:41071 was safe and provided effective discrimination between HER2-positive and HER2-low/negative tumors.
Article
Medicine, Research & Experimental
Jiyun Shi, Shuaifan Du, Rongxi Wang, Hannan Gao, Qi Luo, Guozhu Hou, Yidong Zhou, Zhaohui Zhu, Fan Wang
Summary: HER2-specific imaging can accurately determine HER2 expression in breast cancer patients, and Tc-99m-HP-Ark2 SPECT/CT imaging shows a significant linear correlation with tumor HER2 expression. In a pilot clinical study, Tc-99m-HP-Ark2 SPECT/CT imaging demonstrated high sensitivity (89.5%) and specificity (88.2%) in reflecting HER2 status.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Immunology
Jacques Robert
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Eva-Stina Edholm, Maureen Banach, Kun Hyoe Rhoo, Martin S. Pavelka, Jacques Robert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Toxicology
Lisbeth A. Boule, Timothy J. Chapman, Sara E. Hillman, Christopher D. Kassotis, Colleen O'Dell, Jacques Robert, Steve N. Georas, Susan C. Nagel, B. Paige Lawrence
TOXICOLOGICAL SCIENCES
(2018)
Article
Environmental Sciences
Jacques Robert, Connor C. McGuire, Susan Nagel, B. Paige Lawrence, Francisco De Jesus Andino
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Virology
Eva-Stina Isabella Edholm, Francisco De Jesus Andino, Jinyeong Yim, Katherine Woo, Jacques Robert
Article
Oncology
Maureen Banach, Eva-Stina Edholm, Xavier Gonzalez, Abdellatif Benraiss, Jacques Robert
Review
Microbiology
Laura F. Grogan, Josephine E. Humphries, Jacques Robert, Chantal M. Lanctot, Catherine J. Nock, David A. Newell, Hamish McCallum
Article
Biochemistry & Molecular Biology
Arianna Lopez, Carolyn Shoen, Michael Cynamon, Dionysia Dimitrakopoulou, Matthieu Paiola, Martin S. Pavelka, Jacques Robert
Summary: The study demonstrated the use of Xenopus laevis tadpoles as a complementary model for investigating persistent Mab infection and pathogenesis. Both S and R Mab morphotypes were able to disseminate in tadpole tissues for up to 40 days, with the R morphotype showing higher bacterial load. Intracardiac injection of S Mab led to significantly higher mortality compared to injection of the R Mab form.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Connor C. McGuire, B. Paige Lawrence, Jacques Robert
Summary: Research shows that exposure to a mixture of EDCs can impact thymocyte development, especially during the perinatal stage. The mixture of chemicals is more potent in disrupting thymocyte development compared to individual chemicals. Genes and cells related to thymocyte development show significant alterations after exposure to the mixture.
TOXICOLOGICAL SCIENCES
(2021)
Article
Virology
Yun Tian, Francisco De Jesus Andino, Collins N. Khwatenge, Jiuyi Li, Jacques Robert, Yongming Sang
Summary: This study conducted a comprehensive genome-wide viral transcriptome profiling during FV3 infection across multiple amphibian host tissues. The findings suggest that Ranaviruses like FV3 have acquired previously unknown molecular mimics, interfering with host interferon signaling during evolution. Extensive analysis validated the expression of almost all of the 98 annotated ORFs and profiled their differential expression in a tissue-, virus-, and temporal class-dependent manner.
Article
Immunology
Matthieu Paiola, Siyuan Ma, Jacques Robert
Summary: The fms-related tyrosine kinase 3 (Flt3) and its ligand (Flt3lg) play important roles in hematopoiesis and dendritic cell homeostasis. They show differences among species and duplicated genes in Xenopus laevis. The homoeologs of Flt3 and Flt3lg exhibit conformational divergence and different expression patterns in tadpoles and adult frogs. Flt3lg and Flt3 are involved in XL cell homeostasis and XL cells have hematopoietic origin. In addition, macrophage/monocyte marker Csf1r.S is expressed on XL cells, indicating a common evolutionary origin of vertebrate DCs.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Fisheries
Matthieu Paiola, Dionysia Dimitrakopoulou, Martin S. Pavelka Jr, Jacques Robert
Summary: Mycobacterial infections are a major concern for both humans and vertebrates in aquatic and terrestrial environments. There are common features in the interactions between non-tuberculous mycobacteria and endo-and ectothermic animals, similar to those observed in Mycobacterium tuberculosis infections. The detection of non-tuberculous mycobacteria in amphibians is not only economically damaging but also poses a growing threat to human health.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Fisheries
Connor C. McGuire, Jacques R. Robert
Summary: Immunity can be reprogrammed by environmental chemicals and endocrine signals. Thyroid disrupting chemicals (TDCs) have the potential to affect T cell immunity, but the mechanisms are not well understood. This review discusses the influence of thyroid hormones on T cell development and emerging TDCs that may affect both thyroid hormone physiology and immune outcomes. Using the amphibian Xenopus laevis is recommended for studying the impact of TDCs on immune toxicological endpoints.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Biology
Vania Lopez Ruiz, Jacques Robert
Summary: Amphibians play a crucial role in bridging the evolutionary gap between mammals and ancient vertebrates. Understanding their immune system, which is similar to that of mammals, is important for disease research. The African clawed frog, Xenopus laevis, is a good model for studying the immune system, particularly during early development stages. This review summarizes the knowledge about the innate and adaptive immune system of X. laevis and compares it with other amphibians. It also discusses the response of amphibians to viral, bacterial, and fungal infections.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Editorial Material
Biology
Vania Regina Assis, Jacques Robert, Stefanny Christie Monteiro Titon
Summary: Amphibian populations are declining worldwide due to global climate changes and infectious diseases, such as ranavirosis and chytridiomycosis. The immune mechanisms underlying amphibian disease resistance and host-pathogen interactions are still not well understood. Understanding the stress, disease, and ecoimmunology contexts is crucial for better understanding amphibian immunity and developing effective conservation strategies.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)