Article
Chemistry, Inorganic & Nuclear
Dana Josa, David Aguila, Pere Fontova, Vanessa Soto-Cerrato, Piedad Herrera-Ramirez, Laia Rafols, Arnald Grabulosa, Patrick Gamez
Summary: Five metal-arene complexes and nine cyclometalated half-sandwich complexes were synthesized, characterized, and evaluated for cytotoxicity against human cancer cells. The complexes showed notable cytotoxic properties, particularly against lung adenocarcinoma cells. One of the complexes also exhibited significant toxic effects on other cell lines. Furthermore, the study identified a complex that impacted the cell cycle of lung adenocarcinoma cells.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Niklas Noll, Frank Wuerthner
Summary: The cyclic dinuclear ruthenium complex with oligo(ethylene glycol)-functionalized axial calix[4]arene ligands showed enhanced catalytic activity in water oxidation compared to the mononuclear reference compound. The kinetic studies revealed a unimolecular water nucleophilic attack mechanism for this novel dinuclear water oxidation catalyst, demonstrating its potential for artificial photosynthesis. The photocatalytic performance of this complex was reported to be the highest among Ru(bda) complexes, indicating its promising application in the field of water oxidation research.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Lucinda R. B. Wilson, Marco Coletta, Mukesh K. Singh, Simon J. Teat, Adam Brookfield, Muralidharan Shanmugam, Eric J. L. McInnes, Stergios Piligkos, Scott J. Dalgarno, Euan K. Brechin
Summary: The reaction of 2,2'-bis-p-Bu-t-calix[4]arene (H8L) with Cu(NO3) (2)center dot 3H(2)O and N-methyldiethanolamine (MedeaH(2)) in a basic dmf/MeOH mixture results in the formation of [Cu-II (16)(L)(2)(Me-dea)(4)(mu(4)-NO3)(2)(mu-OH)(4)(dmf)(3.5)(MeOH)(0.5)(H2O)(2)] (H6L)center dot 16dmf center dot 4H(2)O (4). The metallic skeleton of the compound consists of a tetracapped square prism, [Cu-12], with Cu-II ions housed in the calix[4]arene polyphenolic pockets. Magnetic measurements show antiferromagnetic exchange interactions and a ground state of S = 1, while EPR indicates a large zero-field splitting.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Bruno Therrien
Summary: This article discusses the author's contributions to the development and popularity of arene ruthenium assemblies, which have been mainly driven by applications in the biological field. The author has focused on using arene ruthenium building blocks as tools to construct added-value objects for nearly 15 years.
Article
Chemistry, Inorganic & Nuclear
Payal Srivastava, Madhu Verma, Anmol Kumar, Priyanka Srivastava, Ramranjan Mishra, Sri Sivakumar, Ashis K. Patra
Summary: Two water-soluble piano-stool shaped ruthenium(ii)-arene complexes were designed as emissive photocytotoxic agents tagged with morpholine as the lysosome targeting moiety. They showed enhanced photo-cytotoxicity under low-power blue LED light irradiation, preferentially localized in lysosomes and nuclei, effectively targeting and damaging nuclear DNA for photodynamic therapy. Due to enhanced lipophilicity of one complex, it showed higher internalization into cancer cells, with possible binding through histidine residues and internalization via endocytosis. Luminescence properties were utilized to study cellular uptake mechanisms via endocytosis.
DALTON TRANSACTIONS
(2021)
Article
Polymer Science
Qiuxia Wu, Xinran Sun, Zhenming Yang, Pengfei Shi, Huacheng Zhang, Jie Han
Summary: The main challenges in near-infrared region molecular fluorophores are poor water solubility and unknown long-term toxicity. New NIR-II molecular fluorophores have been designed and synthesized, which integrate biocompatible pillar[5]arene and possess aqueous solubility and lowered cellular toxicity. These fluorophores exhibit room-temperature emission, good chemical stability and reasonable self-assembled sizes, showing potential applications in NIR-II imaging.
Article
Biochemistry & Molecular Biology
Lucie Paulus, Manuel Gallardo-Villagran, Claire Carrion, Catherine Ouk, Frederique Martin, Bruno Therrien, David Yannick Leger, Bertrand Liagre
Summary: Prostate cancer is a major health issue and the second most common cancer in men. Photodynamic therapy (PDT) is a non-invasive method that uses photosensitizers and light to induce cell death with minimal side effects. However, some photosensitizers used in PDT have low solubility in biological media, requiring functionalization or vectorization for effective internalization. This study used arene-ruthenium cages to deliver photosensitizers to prostate cancer cells. The results showed that most of the compounds induced cytotoxic effects on prostate cancer cells, with confirmed internalization in the cytoplasm. The presence of metals in the photosensitizers decreased the effectiveness of PDT, and in some cases, completely eliminated its effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Melissa Santi, Ana Katrina Mapanao, Lorenzo Biancalana, Fabio Marchetti, Valerio Voliani
Summary: The study shows that a ruthenium arene compound exhibits significant therapeutic effects on HPV-negative HNSCCs, potentially serving as a promising alternative treatment. Quantitative analysis of internalized Ru compounds validates efficacy and elucidates possible mechanisms of action.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Klaudia Cseh, Heiko Geisler, Kristina Stanojkovska, Julia Westermayr, Philipp Brunmayr, Dominik Wenisch, Natalie Gajic, Michaela Hejl, Martin Schaier, Gunda Koellensperger, Michael A. A. Jakupec, Philipp Marquetand, Wolfgang Kandioller
Summary: The main purpose of this study was to synthesize a new set of naphthoquinone-based ruthenium(II) arene complexes and understand their mode of action. The chemical structures and biological activities of these compounds were examined, and a positive correlation was found between cytotoxicity, lipophilicity, and cellular accumulation. This study provides important insights into the effects of these arene complexes.
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Tianyu Han, Yuying Wu, Weinan Han, Kaiwen Yan, Jian Zhao, Yanyan Sun
Summary: The facile modification of ligands in organometallic Ru(II)-arene complexes provides more opportunities for optimizing their pharmacological profiles. This study designed and synthesized three Ru(II)-arene complexes containing a GST inhibitor (NBDHEX), with in vitro results showing increased activities against tumor cells, especially in complex 3 which demonstrated the highest activity. Complex 3, with more alkyl groups in the arene ligand, exhibited increased electron density at the Ru(II) center leading to improved hydrolysis rate and higher anticancer activity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Arunachalam Abirami, Umapathy Devan, Rengan Ramesh, Arockiam Antony Joseph Velanganni, Jan Grzegorz Malecki
Summary: This study synthesized six arene ruthenium(ii) complexes and evaluated their inhibitory effects on breast cancer cells. The complexes exhibited good antiproliferative activities by inducing apoptotic cell death through an intrinsic mitochondrial pathway.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
G. Attilio Ardizzoia, Daniel Ghiotti, Bruno Therrien, Stefano Brenna
INORGANICA CHIMICA ACTA
(2018)
Article
Chemistry, Physical
Ali Hasnaoui, Ismail Hdoufane, Rachid Idouhli, Bruno Therrien, Mustapha Ait Ali, Larbi El Firdoussi
JOURNAL OF MOLECULAR STRUCTURE
(2019)
Article
Chemistry, Inorganic & Nuclear
G. Attilio Ardizzoia, Gioele Colombo, Bruno Therrien, Stefano Brenna
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Katerina Duskova, Jeremy Lamarche, Souheila Amor, Coralie Caron, Nicolas Queyriaux, Marie Gaschard, Marie-Jose Penouilh, Guillaume de Robillard, Dominique Delmas, Charles H. Devillers, Anton Granzhan, Marie-Paule Teulade-Fichou, Murielle Chavarot-Kerlidou, Bruno Therrien, Sebastien Britton, David Monchaud
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Neelakandan Devika, Subbiah Ananthalakshmi, Nandhagopal Raja, Gajendra Gupta, Bruno Therrien
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Cristina Alvarino, Benoit Heinrich, Bertrand Donnio, Robert Deschenaux, Bruno Therrien
INORGANIC CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Manuel Gallardo-Villagran, David Yannick Leger, Bertrand Liagre, Bruno Therrien
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Inorganic & Nuclear
Wassila Aboura, Lucinda K. Batchelor, Amine Garci, Paul J. Dyson, Bruno Therrien
INORGANICA CHIMICA ACTA
(2020)
Article
Pharmacology & Pharmacy
Manuel Gallardo-Villagran, Lucie Paulus, Jean-Louis Charissoux, Sylvain Sutour, Pascale Vergne-Salle, David Yannick Leger, Bertrand Liagre, Bruno Therrien
Summary: For the first time, ruthenium-based assemblies have been utilized as carriers for photosensitizers in photodynamic therapy for rheumatoid arthritis. Results from the study on fifteen different host-guest systems demonstrate a high potential for treating rheumatoid arthritis with this strategy.
Article
Biochemistry & Molecular Biology
Manuel Gallardo-Villagran, Lucie Paulus, David Yannick Leger, Bruno Therrien, Bertrand Liagre
Summary: This study investigated the effect of DMSO on synoviocytes in RA patients. The results showed that high concentrations of DMSO induced cell death, and even low concentrations of DMSO had a toxic effect on the cells. Therefore, to minimize the impact of DMSO on RA synoviocytes, it is recommended to keep the concentration below 0.05%.
Article
Biochemistry & Molecular Biology
Lucie Paulus, Manuel Gallardo-Villagran, Claire Carrion, Catherine Ouk, Frederique Martin, Bruno Therrien, David Yannick Leger, Bertrand Liagre
Summary: Prostate cancer is a major health issue and the second most common cancer in men. Photodynamic therapy (PDT) is a non-invasive method that uses photosensitizers and light to induce cell death with minimal side effects. However, some photosensitizers used in PDT have low solubility in biological media, requiring functionalization or vectorization for effective internalization. This study used arene-ruthenium cages to deliver photosensitizers to prostate cancer cells. The results showed that most of the compounds induced cytotoxic effects on prostate cancer cells, with confirmed internalization in the cytoplasm. The presence of metals in the photosensitizers decreased the effectiveness of PDT, and in some cases, completely eliminated its effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Bruno Therrien
CHEMISTRY-SWITZERLAND
(2020)
Review
Chemistry, Inorganic & Nuclear
Bruno Therrien
Article
Chemistry, Inorganic & Nuclear
Riccardo Pettinari, Fabio Marchetti, Corrado Di Nicola, Claudio Pettinari, Massimiliano Cuccioloni, Laura Bonfili, Anna Maria Eleuteri, Bruno Therrien, Lucinda K. Batchelor, Paul J. Dyson
INORGANIC CHEMISTRY FRONTIERS
(2019)
Article
Chemistry, Inorganic & Nuclear
Simona Bassoli, G. Attilio Ardizzoia, Bruno Therrien, Stefano Brenna
DALTON TRANSACTIONS
(2019)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)