Review
Biochemistry & Molecular Biology
Daniil Spector, Olga Krasnovskaya, Kirill Pavlov, Alexander Erofeev, Peter Gorelkin, Elena Beloglazkina, Alexander Majouga
Summary: This review summarizes the research on the development of Pt(IV) prodrugs with NSAIDs as axial ligands, their cytotoxic action and anti-inflammatory activity mechanism studies, structure-activity ratio, and therapeutic efficacy. The chemo-anti-inflammatory strategy aims to efficiently deliver cytotoxic metabolites and NSAIDs intracellularly in tumor cells to reduce side effects and increase therapeutic efficacy. Studies have shown high therapeutic efficacy both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Daniil Spector, Kirill Pavlov, Elena Beloglazkina, Olga Krasnovskaya
Summary: Pt(IV) prodrugs with a light-controlled mode of activation show high antiproliferative activity when irradiated, but are non-toxic in the absence of light. This review discusses recent advances in photoabsorber-mediated photocontrollable activation of Pt(IV) prodrugs, focusing on the photocatalytic strategy based on flavin derivatives and the conjugation of photoactive molecules with Pt(II) drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Platinum(IV) prodrugs showed outstanding activity against various cancer cell lines, with nanomolar activities observed. Cellular accumulation of the complexes was correlated with increased cytotoxicity. COX inhibition or lipophilicity did not solely determine the cytotoxicity of these prodrugs.
Article
Chemistry, Multidisciplinary
Alexander Kastner, Hemma Schueffl, Patrick A. Yassemipour, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: Platinum(IV) prodrugs are promising alternatives to platinum(II) anticancer therapeutics. This study investigated the reactivity and synthetic usability of a platinum(IV) complex with hydrolyzable equatorial ligands, and successfully synthesized stable platinum(IV) complexes suitable for long-circulating tumor-targeting strategies. Additionally, platinum(IV) complexes with equatorial maleimides were synthesized, showing prolonged plasma half-life and improved anticancer activity compared to oxaliplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Summary: A new series of cytotoxic platinum(IV) complexes incorporating halogenated phenylacetic acid derivatives were synthesized and evaluated for their biological activity. The results showed that two of the complexes exhibited superior cytotoxicity, with one of them being significantly more potent than cisplatin and the lead complex in a prostate cancer cell line. Further studies were conducted to analyze the physicochemical properties and reactive oxygen species production of the complexes.
Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Man Kshetri, Wjdan Jogadi, Suha Alqarni, Payel Datta, May Cheline, Arpit Sharma, Tyler Betters, Deonya Broyles, Yao-Rong Zheng
Summary: We conducted the first comprehensive investigation on the impact of head group modifications on the anticancer activities of fatty-acid-like Pt(IV) prodrugs (FALPs). We created a small library of FALPs with diverse head group modifications and found that hydrophilic modifications enhanced the potency of these metallodrugs, while hydrophobic modifications decreased their cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Siming Yuan, Yang Zhu, Yi Dai, Yu Wang, Duo Jin, Manman Liu, Liqin Tang, Fabio Arnesano, Giovanni Natile, Yangzhong Liu
Summary: Pt-IV prodrugs can overcome resistance and side effects of conventional Pt-II anticancer therapies by efficiently promoting the two electrons reduction of Pt-IV to Pt-II. The activation of Pt-FBA is highly dependent upon the type of cancer cells, and FBA can shuttle out of the cell after Pt-FBA is reduced intracellularly. The F-19 NMR approach has the advantage of avoiding the interference of all background signals when investigating the activation of Pt-IV prodrugs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Nikola Burdzhiev, Viktoria Elincheva, Georgi Momekov, Denitsa Momekova
Summary: Pt(IV) complexes formed by linking pyrene butyric acid with cisplatin exhibit high anticancer potency against leukemia cells and multidrug-resistant derivatives, while showing low toxicity to healthy cells. The larger bis-pyrene complex is found to potentially be trapped in the cytoskeleton, limiting its cytotoxicity to adherent cells.
Article
Biochemistry & Molecular Biology
Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, Jing Kong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang, Hengshan Wang
Summary: Novel dual target platinum(IV) complexes showed effective antitumor activities with lower toxicity and resistance factors than standard platinum-based chemotherapeutics, by modulating proapoptosis and prosurvival protein expression levels in cancer cells through mitochondrial dysfunction-induced mechanisms. Compound 11 has the potential to be a lead compound for future cancer therapy due to its potency and selectivity.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marie-Christin Barth, Norman Haefner, Ingo B. B. Runnebaum, Wolfgang Weigand
Summary: The research explores the anticancer potential of platinum(IV) complexes and investigates the effects of non-steroidal anti-inflammatory drug (NSAID) ligands on their cytotoxicity. The synthesis and characterization of nine platinum(IV) complexes are presented, and their cytotoxic activity is evaluated against ovarian carcinoma cell lines. The most promising complex, Compound 7, induces cell cycle arrest and apoptosis or necrosis in a cell line-dependent manner, acting through a stress response pathway involving p21, CHOP, and ATF3 genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Four platinum(IV) prodrugs incorporating a biotin moiety showed exceptional cytotoxicity against cancer cell lines. One of the prodrugs exhibited the lowest cytotoxicity in prostate cancer cells, while another prodrug showed higher activity in colon cancer cells. Some prodrugs also demonstrated selectivity towards breast cancer cells compared to healthy cells, which was not observed with their platinum(II) precursors.
Article
Chemistry, Inorganic & Nuclear
Carlo Marotta, Ester Giorgi, Francesca Binacchi, Damiano Cirri, Chiara Gabbiani, Alessandro Pratesi
Summary: The discovery of cisplatin's antineoplastic properties in 1965 renewed the interest in metal complexes for medicinal applications. Researchers have been studying safer and more effective alternatives to cisplatin, including platinum(IV)-based compounds. These compounds have attracted attention because they can be reduced in cells to activate the platinum center and offer advantages such as reducing side effects. This review summarizes the recent achievements in the field of Pt(IV) prodrugs.
INORGANICA CHIMICA ACTA
(2023)
Article
Engineering, Biomedical
Dongquan Xiang, Xinli Han, Jianxiong Li, Jiabing Zhang, Haihua Xiao, Ting Li, Xuelin Zhao, Hejian Xiong, Meng Xu, Wenzhi Bi
Summary: Researchers designed composite nanoparticles (NP-Pt-IDOi) to encapsulate a Pt(IV) prodrug (Pt(IV)-C12) and an IDO inhibitor (NLG919) for the treatment of osteosarcoma. These nanoparticles can dissociate inside cancer cells due to intracellular ROS, releasing Pt(IV)-C12 and NLG919. They have shown superior anti-cancer activity in vitro and in vivo, providing a new clinical paradigm for combining chemotherapy with immunotherapy for osteosarcoma.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Inorganic & Nuclear
Ying Tu, Hao-Ming Li, Meng-Meng Wang, Yan Su, Hong-Ke Liu, Zhi Su
Summary: This study developed a dual-targeted platinum (IV) prodrug Pt-CMN, which significantly enhanced anticancer performance and provided a new strategy for enhancing anticancer effects through subcellular organelle targeting.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jun Xiang Ong, Wee Han Ang
CHEMISTRY-AN ASIAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Max Jing Rui Tham, Maria V. Babak, Wee Han Ang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Materials Science, Multidisciplinary
Daryl Darwan, Kang Rui Garrick Lim, Hadhi Wijaya, Zhi Chiaw Lim, Tian Wang, Wee Han Ang, Zhi-Kuang Tan
ADVANCED OPTICAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Kang Rui Garrick Lim, Daryl Darwan, Hadhi Wijaya, Zhi Chiaw Lim, Janaki Shanmugam, Tian Wang, Li Jun Lim, Wee Han Ang, Zhi-Kuang Tan
ADVANCED MATERIALS INTERFACES
(2020)
Editorial Material
Chemistry, Multidisciplinary
Boon Shing Loh, Wee Han Ang
ACS CENTRAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Kateryna Ohui, Iryna Stepanenko, Iuliana Besleaga, Maria V. Babak, Radu Stafi, Denisa Darvasiova, Gerald Giester, Vivien Posa, Eva A. Enyedy, Daniel Vegh, Peter Rapta, Wee Han Ang, Ana Popovic-Bijelic, Vladimir B. Arion
Article
Chemistry, Multidisciplinary
Jun Xiang Ong, Hai Van Le, Violet Eng Yee Lee, Wee Han Ang
Summary: Mitochondria have been identified as important targets for cisplatin in cancer treatment. In addition to cisplatin, anticancer Pt complexes with similar structures have been developed to target mitochondria. The researchers developed a mitochondria-targeted fluorescent probe to monitor Pt accumulation in mitochondria in real time, and identified two distinct pathways through which Pt complexes could be delivered to mitochondria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Violet Eng Yee Lee, Zhi Chiaw Lim, Suet Li Chew, Wee Han Ang
Summary: A common challenge in Pt(IV) prodrug design is the limited repertoire of linkers available to connect the Pt(IV) scaffold with the bioactive payload. This study introduces a new class of Pt(IV) prodrugs using masked self-immolative 4-aminobenzyl linkers for controlled and traceless codrug delivery, which proved to be more effective than traditional methods in vitro.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Maria V. Babak, Kai Ren Chong, Peter Rapta, Markella Zannikou, Hui Min Tang, Lisa Reichert, Meng Rui Chang, Vladimir Kushnarev, Petra Heffeter, Samuel M. Meier-Menches, Zhi Chiaw Lim, Jian Yu Yap, Angela Casini, Irina V. Balyasnikova, Wee Han Ang
Summary: The study developed a novel drug complex 3met which can induce deadly metabolic catastrophe in triple-negative breast cancer, reducing tumor burden and significantly improving treatment outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Cheng Weng, Hui Yang, Boon Shing Loh, Ming Wah Wong, Wee Han Ang
Summary: This study reports the development of a synthetic small-molecule NTR system based on transfer hydrogenation mediated by transition metal complexes. The water-stable Ru-arene complex can selectively and fully reduce nitroaromatics into anilines in a biocompatible buffered aqueous environment using formate as the hydride source. The application of this system in activating nitro-caged sulfanilamide prodrug in formate-abundant bacteria, specifically methicillin-resistant Staphylococcus aureus, has been demonstrated.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Cheng Weng, Yong Leng Kelvin Tan, Wayne Gareth Koh, Wee Han Ang
Summary: Antimicrobial resistance is a serious and urgent threat to global public health, and the limited development of new drugs with alternative modes of action exacerbates this problem. Transition metal complexes can provide compounds with unique properties that are not easily accessible using pure organic scaffolds, replenishing the diminishing stockpile of drug candidates. This review highlights four emerging antibacterial strategies that harness the unique chemical properties of transition metal complexes, namely Trojan horse, triggered warhead release, new-to-nature chemistry, and biomimetic reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Cheng Weng, Linghui Shen, Jin Wei Teo, Zhi Chiaw Lim, Boon Shing Loh, Wee Han Ang
Summary: The use of organotransition metal complexes for oxidoreduction allows for targeted oxidative stress in Gram-positive bacteria, particularly methicillin-resistant Staphylococcus aureus. This innovative strategy based on redox chemistry of organotransition metal complexes provides a potential solution to combat drug resistance.
Article
Oncology
Guowei Kim, Hon Lyn Tan, Raghav Sundar, Bettina Lieske, Cheng Ean Chee, Jingshan Ho, Asim Shabbir, Maria Babak, Wee Han Ang, Boon Cher Goh, Wei Peng Yong, Lingzhi Wang, Jimmy B. Y. So
Summary: This study investigates the safety and tolerability of PIPAC oxaliplatin for peritoneal metastases from gastrointestinal tumors, concluding that the recommended phase II dose is 120 mg/m(2). Further studies are needed to clarify the efficacy and role of PIPAC oxaliplatin for peritoneal metastases.
CLINICAL CANCER RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Wee Han Ang, Bengang Xing
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Hai Van Le, Maria Babak, Muhammad Ali Ehsan, Muhammad Altaf, Lisa Reichert, Artem L. Gushchin, Wee Han Ang, Anvarhusein A. Isab
DALTON TRANSACTIONS
(2020)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)