Article
Endocrinology & Metabolism
Ross Hamblin, Athanasios Fountas, Kirstie Lithgow, Paul Benjamin Loughrey, Efstathios Bonanos, Shah Khalid Shinwari, Kirsten Mitchell, Syed Shah, Lydia Grixti, Mike Matheou, Kristina Isand, David S. McLaren, Ashutosh Surya, Hafiz Zubair Ullah, Katarina Klaucane, Anuradha Jayasuriya, Sumbal Bhatti, Akash Mavilakandy, Masato Ahsan, Susan Mathew, Ziad Hussein, Thijs Jansz, Wunna Wunna, James MacFarlane, John Ayuk, Prakash Abraham, William M. Drake, Mark Gurnell, Antonia Brooke, Stephanie E. Baldeweg, Amir H. Sam, Niamh Martin, Claire Higham, Narendra Reddy, Miles J. Levy, Rupa Ahluwalia, John Newell-Price, Joannis Vamvakopoulos, Amutha Krishnan, Andrew Lansdown, Robert D. Murray, Aparna Pal, Karin Bradley, Yaasir Mamoojee, Tejpal Purewal, Janki Panicker, E. Marie Freel, Faisal Hasan, Mohit Kumar, Biju Jose, Steven J. Hunter, Niki Karavitaki
Summary: This study provides evidence on the natural history of non-functioning pituitary microadenomas (micro-NFPAs) and suggests that the probability of micro-NFPA growth is low, and the development of new hypopituitarism is rare. Delaying the first follow-up MRI to 3 years and avoiding hormonal re-evaluation in the absence of tumor growth or clinical manifestations is a safe approach for micro-NFPA surveillance.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Bai, Yu Shen, Rushi Chen, Xianchang Zhang, Mathias Nittka, Gregor Koerzdoerfer, Qiyong Gong, Meiyun Wang
Summary: Magnetic resonance fingerprinting (MRF) can effectively differentiate gonadotroph from non-gonadotroph pituitary macroadenomas, guiding treatment decisions.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Kaori Takeshita, Ichiro Abe, Wataru Kameda, Kota Ishii, Yuya Fujita, Mai Nagata, Kentaro Ochi, Yuki Senda, Midori Koga, Tadachika Kudo, Yurika Hada, Kaoru Takase, Yusuke Morinaga, Miiko Ito, Makiko Abe, Kenichi Ishizawa, Kunihisa Kobayashi
Summary: Pituitary apoplexy is a rare syndrome that often leads to spontaneous bleeding or infarction in pituitary tumors or glands. This study found that pituitary apoplexy occurs most frequently in patients with nonfunctional pituitary adenomas and is not related to tumor size. However, it is associated with hormonal deficiencies, liver dysfunction, hyponatremia or hypochloremia, and dyslipidemia.
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jiayin Qin, Kai Li, Xijuan Wang, Yongzhen Bao
Summary: This study aimed to investigate the differences in visual impairment caused by functioning and non-functioning pituitary adenomas. It was found that patients with functioning pituitary adenomas had better corrected visual acuity and lighter visual field defects compared to those with non-functioning pituitary adenomas. Additionally, tumor volume was correlated with visual field defects in both groups.
Review
Medicine, General & Internal
Ana-Maria Gheorghe, Alexandra-Ioana Trandafir, Mihaela Stanciu, Florina Ligia Popa, Claudiu Nistor, Mara Carsote
Summary: This article provides new insights into the challenges of pituitary apoplexy during pregnancy and the postpartum period. The study includes a review of 35 original studies and highlights the importance of prompt recognition of headache as the main clinical feature. Most patients receive conservative management with corticosteroid substitution and dopamine agonists. Surgical intervention is reserved for cases with neuro-ophthalmological deterioration. This study is clinically significant for obstetricians and neurologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Georgia Ntali, Cristina Capatina
Summary: Functioning gonadotroph adenomas (FGAs) are rare tumors that can cause clinical syndromes due to over secretion of gonadotropins. Surgical removal of the tumor improves endocrine dysfunction and provides tissue for analysis. Medical therapies have limited effectiveness in treating these tumors.
MEDICINA-LITHUANIA
(2022)
Editorial Material
Clinical Neurology
Ana Isabel Almeida, Jose Maria Sousa, Luisa Sampaio
Summary: Tension pneumosella is a very rare complication of pituitary transsphenoidal surgery. We report the second case of pituitary adenoma pneumo-apoplexy, characterized by findings consistent with tension pneumosella in the context of apoplexy of a pituitary adenoma. Although it is an extremely rare diagnosis, it should be considered in patients with compatible clinical and radiological findings, particularly with a previous history of transsphenoidal pituitary surgery.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Mehdi Akhavan-Bahabadi, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study identified differentially expressed genes (DEGs), including long non-coding RNAs (DElncRNAs) and microRNAs (DEmiRNAs), in non-functioning pituitary adenomas (NFPA) compared to normal samples. The study also assessed the relationship between these genes and important signaling pathways. The findings revealed dysregulated pathways and differential expression of several genes in NFPA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Mayo Ono, Izumi Fukuda, Akimi Soga, Shigeyuki Tahara, Akio Morita, Hitoshi Sugihara
Summary: Incidental pituitary tumors are generally smaller, found in older patients, have a lower incidence of hormone deficiency, and show better preservation of pituitary function postoperatively. Close observation and appropriate decision-making are important to prevent incidentalomas from progressing into symptomatic tumors.
Article
Clinical Neurology
Mark T. Mills, Stephen B. Wharton, Daniel J. Connolly, Showkat Mirza, Saurabh Sinha
Summary: This is a rare case describing metastasis of breast cancer into a gonadotroph cell pituitary adenoma presenting as apoplexy.
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Betina Biagetti, Silvana Sarria-Estrada, Esteban Cordero Asanza, Anas Chaachou-Charradi, Yiken Karelys Ng-Wong, Marta Cicuendez, Irene Hernandez, Alba Rojano-Toimil, Pilar Costa, Elena Martinez-Saez, Anna Casteras, Rafael Simo
Summary: This study describes the clinical characteristics and evolution of patients with APA compared to SPA. The results show that APA is more frequent in larger NFPAs and this subset of patients has a higher risk of surgery. Hypopituitarism is quite frequent even in patients with SPA, and therefore long-term follow-up is necessary.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ben A. Strickland, Shane Shahrestani, Robert G. Briggs, Anna Jackanich, Sherwin Tavakol, Kyle Hurth, Mark S. Shiroishi, Chia-Shang J. Liu, John D. Carmichael, Martin Weiss, Gabriel Zada
Summary: SCAs are a subtype of NFAs that are more biologically aggressive, with patients presenting with more cranial neuropathy and headaches, and a shorter progression-free survival duration.
JOURNAL OF NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Valentina Puglisi, Elisabetta Morini, Fiammetta Biasini, Luisa Vinciguerra, Giuseppe Lanza, Placido Bramanti
Summary: This is a case report on giant pituitary tumor apoplexy, presenting a rare case of an 81-year-old female with this condition. The authors highlight the importance of prompt diagnosis and multidisciplinary management in achieving significant improvement in symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Carl Mathis Wild, Mareike Stieg, Guenter K. Stalla, Caroline Jung-Sievers, Matthias K. Auer, Anastasia P. Athanasoulia-Kaspar
Summary: This study evaluates sleep patterns of patients treated for non-secreting intra- and parasellar tumors compared to healthy controls. The findings show that patients experience altered sleep patterns and suggest possible interventions for managing clinicians to improve sleep and quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Endocrinology & Metabolism
Frederic Castinetti, Vincent Amodru, Thierry Brue
Summary: This short manuscript reports three cases of atypical adrenal insufficiency with osilodrostat, which is highly effective in blocking cortisol secretion but also carries the risk of adrenal insufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maxime Barat, Martin Gaillard, Anne-Segolene Cottereau, Elliot K. Fishman, Guillaume Assie, Anne Jouinot, Christine Hoeffel, Philippe Soyer, Anthony Dohan
Summary: In the field of adrenal imaging, artificial intelligence (AI) can be used for lesion detection, characterization, syndrome management, and patient follow-up. Although a perfect AI tool that covers all necessary steps from detection to analysis does not yet exist, multiple AI algorithms have been developed and tested with promising outcomes. However, AI in this setting is still in its early stages, and most published studies on AI in adrenal gland imaging provide preliminary results that have not yet found daily applications in clinical practice. This review presents recent developments and current results of AI in adrenal imaging and discusses the limitations and future perspectives of AI.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Correction
Oncology
M. Fassnacht, G. Assie, E. Baudin, G. Eisenhofer, C. de la Fouchardiere, H. R. Haak, R. de Krijger, F. Porpiglia, M. Terzolo, A. Berruti, ESMO Guidelines Comm
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Audrey Ziverec, Marie Chanal, Perrine Raymond, Mirela Diana Ilie, Dario De Alcubierre, Arja Pasternack, Olli Ritvos, Gerald Raverot, Philippe Bertolino
Summary: Pituitary tumours are benign neoplasms derived from hormone-producing cells of the pituitary gland. Gonadotroph tumours expressing FSH and/or luteinizing hormone lack therapeutic options apart from surgery and radiotherapy. Activin ligands play a role in FSH production but their role in gonadotroph tumourgenesis is little explored.
ENDOCRINE-RELATED CANCER
(2023)
Article
Endocrinology & Metabolism
Alexandre Dormoy, Magalie Haissaguerre, Geraldine Vitellius, Christine Do Cao, Aurore Geslot, Delphine Drui, Helene Lasolle, Oceana Vieira-Pinto, Sylvie Salenave, Maud Francois, Marie Puerto, Helene Du Boullay, Anne Mayer, Anne Rod, Claire Laurent, Philippe Chanson, Yves Reznik, Frederic Castinetti, Olivier Chabre, Eric Baudin, Gerald Raverot, Antoine Tabarin, Jacques Young
Summary: This study evaluated the efficacy and safety of osilodrostat in patients with PNCS/EAS in France, and found that osilodrostat had significant efficacy in reducing hypercortisolism symptoms in these patients and was generally well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossella Libe, Aurore Pais, Florian Violon, Laurence Guignat, Fideline Bonnet, Olivier Huillard, Guillaume Assie, Martin Gaillard, Bertrand Dousset, Sebastien Gaujoux, Maxime Barat, Anthony Dohan, Mathilde Sibony, Jerome Bertherat, Anne Segolene Cottereau, Florence Tenenbaum, Joel Coste, Lionel Groussin
Summary: This study found that most ACCs demonstrate high F-18-FDG uptake, but the positive correlation observed between SUVmax and Ki-67 expression levels seems to explain the possibility of identifying some ACCs with low or inexistent F-18-FDG uptake, which has practical implications for the management of patients with an adrenal mass.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fideline Bonnet-Serrano, Clara Devin-Genteuil, Louis Thomeret, Christelle Laguillier-Morizot, Marie-Clemence Leguy, Anna Vaczlavik, Lucas Bouys, Corinne Zientek, Leopoldine Bricaire, Laura Bessiene, Laurence Guignat, Rossela Libe, Helen Mosnier-Pudar, Guillaume Assie, Lionel Groussin, Jean Guibourdenche, Jerome Bertherat
Summary: Diagnosis of endogenous hyperinsulinism relies on a hypoglycemia with low insulin and C-peptide levels. Optimized cutoffs were proposed for glycemia, insulin, and C-peptide levels for diagnosis. C-peptide level of 0.3 nmol/L with a hypoglycemia <2.3 mmol/L appears to be the best criterion for diagnosing endogenous hyperinsulinism.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Vincent Amodru, Amandine Ferriere, Antoine Tabarin, Frederic Castinetti, Stylianos Tsagarakis, Miklos Toth, Richard A. Feelders, Susan M. Webb, Martin Reincke, Romana Netea-Maier, Darko Kastelan, Atanaska Elenkova, Dominique Maiter, Oskar Ragnarsson, Alicia Santos, Elena Valass
Summary: This study aimed to evaluate age-related differences in clinical characteristics, diagnostic approaches, and management strategies in patients with Cushing's syndrome. Older patients had lower BMI and waist circumference, and a higher prevalence of comorbidities such as muscle weakness, diabetes, hypertension, and cardiovascular disease. They also showed different treatment preferences, with older patients more likely to receive conservative treatment and younger patients preferring surgery.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kamel Mohammedi, Jerome Bertherat, Gerald Raverot, Delphine Drui, Yves Reznik, Frederic Castinetti, Philippe Chanson, Manon Fafin, Julie Brossaud, Antoine Tabarin
Summary: This study assessed the long-term cortisol exposure in medically treated Cushing disease (CD) patients by measuring the levels of hair cortisol and hair cortisone. Despite normalized urinary free cortisol levels, a subset of patients still displayed altered circadian rhythm of cortisol secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Thi Thom Mac, Frederic Castinetti, Celine Bar, Sophie Julia, Marlene Pasquet, Pauline Romanet, Alexandru Saveanu, Gregory Mougel, Teddy Fauquier, Nicolas Jullien, Anne Barlier, Rachel Reynaud, Thierry Brue
Summary: Deficient anterior pituitary with common variable immune deficiency (DAVID) syndrome is a rare condition characterized by ACTH deficiency and primary hypogammaglobulinemia caused by NFKB2 gene mutations. A new case of DAVID syndrome was identified and a review of published cases was conducted. Early diagnosis of DAVID syndrome is important to prevent life-threatening complications.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Neurosciences
Gianpaolo Jannelli, Francesco Calvanese, Luca Paun, Gerald Raverot, Emmanuel Jouanneau
Summary: Craniopharyngiomas are classified as low-grade tumors, but they can exhibit malignant behavior due to high recurrence rates and long-term morbidity. They are divided into two types (adamantinomatous and papillary), which are considered independent entities based on epidemiological, radiological, histopathological, and genetic patterns. Papillary craniopharyngioma frequently has a BRAF V600 mutation, which has opened new possibilities for treatment. This article presents an overview of recent literature on the specificities and the role of oncological treatment in managing papillary craniopharyngiomas.
Article
Obstetrics & Gynecology
Georgios E. Papadakis, Benedicte de Kalbermatten, Alexandre Dormoy, Sylvie Salenave, Severine Trabado, Oceana Vieira-Pinto, Carine Richa, Peter Kamenicky, Philippe Chanson, Luigi Maione, Nelly Pitteloud, Jacques Young
Summary: Cushing's syndrome (CS) affects the gonadotrope axis and testicular functions differently depending on the intensity of hypercortisolism and underlying etiology. Excess cortisol caused by CS leads to varying degrees of hypogonadotropic hypogonadism (HH), with more severe impairment in men with intense hypercortisolism associated with paraneoplastic/ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS).
HUMAN REPRODUCTION
(2023)
Editorial Material
Medicine, General & Internal
Frederic Castinetti, Francoise Borson-Chazot
Summary: Medullary thyroid cancer, although a rare form of thyroid cancer, is significant due to its phenotypic heterogeneity and aggressive behavior, as well as the lack of curative postoperative treatment. About 25% of cases are associated with the genetic tumor syndrome MEN-2, and the first drug targeting the RET gene pathway has been recognized on the 30th anniversary of its discovery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Environmental Sciences
Sylvain Chamot, Abdallah Al-Salameh, Pascal Petit, Vincent Bonneterre, Christophe Cance, Guillaume Decocq, Agnes Boullier, Karine Braun, Rachel Desailloud
Summary: Systematic screening for congenital hypothyroidism in Picardy, France revealed unexpected heterogeneity in the geographic distribution of newborn thyroid-stimulating hormone concentrations, potentially related to environmental pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
