期刊
DALTON TRANSACTIONS
卷 39, 期 35, 页码 8195-8202出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0dt00238k
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The synthesis and the investigation of the Cu(II)-binding, the DNA-binding, and the DNA-damaging properties of a conjugate between the benzo[b]quinolizinium ion and the bis(pyridin-2-ylmethyl)amino receptor are presented. Photometric and fluorimetric titrations as well as CD spectroscopic analysis reveal that the 9-bis(pyridin-2-ylmethyl) aminobenzo[b] quinolizinium ligand intercalates into DNA (K-b = 1.9 x 10(4) M-1) and exhibits a high selectivity towards complexation of Cu2+ in water (K-b = 4.3 x 10(4) M-1). This combination of functionalities allows to localize Cu2+ in close proximity of DNA, where these metal ions induce efficient DNA damage, as shown by the single-strand cleavage of supercoiled plasmid DNA. Notably, the DNA cleavage does not require additional reagents nor light.
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