Catalytic (transfer) deuterogenation in D2O as deuterium source with H-2 and HCO2H as electron sources

Deuterium-labelled compounds were prepared by (transfer) deuterogenation of unsaturated compounds using H-2 or HCO2H in acidic D2O as deuterium source with almost quantitative yields and high deuterium contents under mild reaction conditions via heterolytic cleavage of H-2 (or decomposition of HCO2H) and rapidH(+)/D+ exchange using iridium catalysts with 4,4'-dihydroxy-2,2'-bipyridine.