期刊
CYTOTHERAPY
卷 20, 期 10, 页码 1204-1219出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2018.06.012
关键词
diagnosis; exosomes; ischemia; myocardial infarction; stroke; therapeutics
类别
资金
- National Natural Science Foundation of China [81771271]
- Program of Basic and Clinical Research Platform of China Medical University [CMU-201406]
- Second Batch of Basic Clinical Closely Combined Platform Project [S208]
- Shengjing Hospital of China Medical University
In the past, exosomes have been thought of as cellular dust. Today, they are thought to be carriers of real biomarkers and intercellular biological information. The composition of exosomes differs according to their source, and the subsequent information they carry, such as protein, microRNA or mRNA, may also be different. Recent studies have demonstrated that exosomes in ischemic diseases can help to make an early diagnosis, and in cellular experiments and animal models, exosomes promote angiogenesis, restrain cell apoptosis and reduce inflammation, among other actions, to protect ischemic organs. There is evidence that these protective effects are related to microRNAs in exosomes. In this review, we discuss the use of exosomes for early diagnosis of ischemic diseases and recent advances in the therapeutic use of exosomes in cell and mammalian models of ischemic diseases.
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