期刊
CYTOTHERAPY
卷 12, 期 6, 页码 767-782出版社
ELSEVIER SCI LTD
DOI: 10.3109/14653241003786148
关键词
hematopoietic stem cells; megakaryocyte progenitor cells; megakaryocytic cells; nicotinamide
类别
资金
- NSF [CBET-0853603]
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- NIH [T32 GM 008449]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0853603] Funding Source: National Science Foundation
Background aims. Megakaryopoiesis encompasses hematopoietic stem and progenitor cell (HSPC) commitment to the megakaryocytic cell (Mk) lineage, expansion of Mk progenitors and mature Mks, polyploidization and platelet release. pH and pO(2) increase from the endosteum to sinuses, and different cytokines are important for various stages of differentiation. We hypothesized that mimicking the changing conditions during Mk differentiation in the bone marrow would facilitate expansion of progenitors that could generate many high-ploidy Mks. Methods. CD34
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