期刊
CYTOTHERAPY
卷 10, 期 8, 页码 775-783出版社
ELSEVIER SCI LTD
DOI: 10.1080/14653240802648181
关键词
NK cells; immunotherapy; innate immunity; allogenic transplant; killer IgG like receptors (KIR); renal cell carcinoma
类别
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL002345, Z01HL002345] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 HL002345, ZIA HL006090, ZIA HL002345] Funding Source: Medline
Recently there has been a substantial gain in our understanding of the role NK-cells play in mediating innate host immune responses. Although NK cells have long been known to mediate antigen independent tumor cytotoxity, the therapeutic potential of NK cell-based immunotherapy has yet to be realized. Manipulating the balance between inhibitory and activating NK receptor signals, sensitization of tumor target cells to NK cell-mediated apoptosis, and recent discoveries in NK-cell receptor biology have fueled translational research that has led to clinical trials investigating a number of novel methods to potentiate NK cytotoxicity against human malignancies.
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