The chemical complexity of cellular microtubules: Tubulin post-translational modification enzymes and their roles in tuning microtubule functions

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium

(2012) Ji Eun Lee et al.   NATURE GENETICS

Design, Overexpression, and Purification of Polymerization-Blocked Yeast αβ-Tubulin Mutants

(2011) Vinu Johnson et al.   BIOCHEMISTRY

The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans

(2011) Robert O'Hagan et al.   CURRENT BIOLOGY

Tubulin Tyrosine Ligase-like Genesttll3andttll6Maintain Zebrafish Cilia Structure and Motility

(2011) Narendra Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

(2011) Agnieszka Szyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Site-Specific Orthogonal Labeling of the Carboxy Terminus of α-Tubulin

(2010) Abhijit Banerjee et al.   ACS Chemical Biology

Distinct α- and β-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the ‘multi-tubulin’ hypothesis

(2010) Max A. Tischfield et al.   BIOSCIENCE REPORTS

Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement

(2010) R. A. Whipple et al.   CANCER RESEARCH

Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells

(2010) K. Kashiwaya et al.   CANCER RESEARCH

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

(2010) Swati Suryavanshi et al.   CURRENT BIOLOGY

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

(2010) Tomohiro Kubo et al.   CURRENT BIOLOGY

Influence of Combinatorial Histone Modifications on Antibody and Effector Protein Recognition

(2010) Stephen M. Fuchs et al.   CURRENT BIOLOGY

Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy

(2010) Christine Wasylyk et al.   INTERNATIONAL JOURNAL OF CANCER

Giardia Duodenalis 14-3-3 Protein Is Polyglycylated by a Tubulin Tyrosine Ligase-like Member and Deglycylated by Two Metallocarboxypeptidases

(2010) Marco Lalle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules

(2010) Jonathan R. Friedman et al.   JOURNAL OF CELL BIOLOGY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

Post-translational modifications of microtubules

(2010) D. Wloga et al.   JOURNAL OF CELL SCIENCE

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts

(2010) H. Sudo et al.   JOURNAL OF NEUROSCIENCE

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

An assessment of histone-modification antibody quality

(2010) Thea A Egelhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry

(2010) K. Ikegami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin Tyrosine Ligase–Like 1 Deficiency Results in Chronic Rhinosinusitis and Abnormal Development of Spermatid Flagella in Mice

(2010) P. Vogel et al.   VETERINARY PATHOLOGY

Acetylated tubulin associates with the fifth cytoplasmic domain of Na+/K+-ATPase: possible anchorage site of microtubules to the plasma membrane

(2009) Guillermo G. Zampar et al.   BIOCHEMICAL JOURNAL

Recombinant Mammalian Tubulin Polyglutamylase TTLL7 Performs both Initiation and Elongation of Polyglutamylation on β-Tubulin through a Random Sequential Pathway†

(2009) Masahiro Mukai et al.   BIOCHEMISTRY

Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation

(2009) Krzysztof Rogowski et al.   CELL

Microtubule-severing enzymes

(2009) Antonina Roll-Mecak et al.   CURRENT OPINION IN CELL BIOLOGY

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

(2009) Dorota Wloga et al.   DEVELOPMENTAL CELL

Hyperglutamylation of Tubulin Can either Stabilize or Destabilize Microtubules in the Same Cell

(2009) Dorota Wloga et al.   EUKARYOTIC CELL

TTLL10 can perform tubulin glycylation when co-expressed with TTLL8

(2009) Koji Ikegami et al.   FEBS LETTERS

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY

Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells

(2009) M. J. Wozniak et al.   JOURNAL OF CELL SCIENCE

Probing Interactions between CLIP-170, EB1, and Microtubules

(2009) Kamlesh K. Gupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau - an inhibitor of deacetylase HDAC6 function

(2009) Mar Perez et al.   JOURNAL OF NEUROCHEMISTRY

Post-translational modifications of tubulin in the nervous system

(2009) Nobuyuki Fukushima et al.   JOURNAL OF NEUROCHEMISTRY

Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons

(2009) Jennetta W. Hammond et al.   MOLECULAR BIOLOGY OF THE CELL

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Microtubule plus-end tracking by CLIP-170 requires EB1

(2009) R. Dixit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Glutamylation on α-Tubulin Is Not Essential but Affects the Assembly and Functions of a Subset of Microtubules inTetrahymena thermophila

(2008) Dorota Wloga et al.   EUKARYOTIC CELL

TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1

(2008) Koji Ikegami et al.   FEBS LETTERS

Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules

(2008) Elias T. Spiliotis et al.   JOURNAL OF CELL BIOLOGY

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites

(2008) Peter Bieling et al.   JOURNAL OF CELL BIOLOGY

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY