Article
Physiology
Lilya Lehka, Dominika Wojton, Malgorzata Topolewska, Vira Chumak, Lukasz Majewski, Maria Jolanta Redowicz
Summary: MVI plays an important role in muscle function and myogenesis. The lack of MVI leads to impaired PKA signaling and alterations in muscle metabolism, particularly in newborn mice.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Makenna M. Morck, Debanjan Bhowmik, Divya Pathak, Aminah Dawood, James Spudich, Kathleen M. Ruppel
Summary: Mutations in the lever arm of beta-cardiac myosin have divergent allosteric effects on myosin function, depending on whether they are in the pliant or light chain-binding regions.
Article
Chemistry, Multidisciplinary
Oleg S. Matusovsky, Noriyuki Kodera, Caitlin MacEachen, Toshio Ando, Yu-Shu Cheng, Dilson E. Rassier
Summary: This study used high-speed atomic force microscopy to visualize the actin-myosin complex and revealed detailed information about the myosin mechanism of force generation.
Review
Physiology
Thomas D. Pollard, Edward D. Korn
Summary: This article describes the isolation of a novel unconventional myosin from Acanthamoeba, as well as the identification of a cofactor that interacts with it.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Zhaohui Ouyang, Shuangshuang Zhao, Su Yao, Jing Wang, Yanqin Cui, Ke Wei, Yaming Jiu
Summary: Myosin-18 family, including myosin-18A and myosin-18B, lacks ATPase motor activity but plays crucial roles in cell motility, sarcomere formation, and mechanosensing. Myosin-18A is involved in intracellular transport processes, while myosin-18B participates in actomyosin alignment. Mutations of Myo18a or Myo18b in mice result in cardiac developmental defects, highlighting their importance in muscle development and cardiac diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Yong Hyeon Cho, Woo Jung Park, Chan Gook Park
Summary: This paper proposes two novel methods to mitigate lever arm effect in RIMUs, increasing the accuracy of compensating for the effect. These methods use lever arm vectors and nonlinear least squares method in different ways, providing higher computational efficiency and overall navigation performance compared to previous methods.
IEEE SENSORS JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Chloe A. Johnson, Ranya Behbehani, Folma Buss
Summary: Unconventional myosins are a superfamily of actin-based motor proteins that play important roles in cellular processes. Humans have 40 myosin genes, and mutations in these genes are associated with various pathologies, while over-expression can lead to cancer. Caenorhabditis elegans is a valuable tool to study these genes and human diseases.
Article
Engineering, Electrical & Electronic
Yoonjin Hwang, Yongseop Jeong, In So Kweon, Seibum B. Choi
Summary: The proposed method presents a novel approach for identifying vehicle dynamics model and sensor lever-arm, effectively addressing the issue of traditional methods not being able to simultaneously identify model parameters and lever-arms. By utilizing a modified model and unscented Kalman filter, high identification accuracy can be achieved under various experimental conditions.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Civil
Jose Christian Golondrino, Gregory Anthony MacRae, James Geoffrey Chase, Geoffrey William Rodgers, George Charles Clifton
Summary: This study conducted quasi-static testing on Asymmetric Friction Connections and found that the ratio of bolt lever arm to bolt diameter has a significant impact on the sliding performance of AFCs. Increasing this ratio led to decreased strength and loading stiffness of AFCs, as well as a reduction in the effective friction coefficient.
JOURNAL OF EARTHQUAKE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Karen Baker, Michael A. Geeves, Daniel P. Mulvihill
Summary: This study investigates the impact of amino-terminal acetylation on the structure and function of fission yeast calmodulin. The findings show that NatA-dependent acetylation stabilizes the structure and affects the ability of calmodulin to bind to myosin at endocytic foci. Furthermore, the study reveals that this conserved modification also influences the calcium-binding capacity of both yeast and human calmodulins.
Article
Biochemistry & Molecular Biology
Olena Karatsai, Lilya Lehka, Dominika Wojton, Anna Izabela Grabowska, Monika Katarzyna Duda, Robert Lenartowski, Maria Jolanta Redowicz
Summary: Hypertrophic cardiomyopathy is a common cardiovascular disease caused by gene mutations, resulting in structural and functional abnormalities in the myocardium. Unconventional myosin VI (MVI) plays a role in heart function, and its absence leads to heart enlargement and dysfunction. Mechanisms underlying this dysfunction include increased cardiomyocyte proliferation, disorganization of intercalated discs, and altered sarcoplasmic reticulum.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Genetics & Heredity
Laura Marie-Hardy, Thomas Courtin, Hugues Pascal-Moussellard, Serge Zakine, Alexis Brice
Summary: This study analyzed whole-exome sequencing data from 113 individuals in 19 multi-generational families with adolescent idiopathic scoliosis (AIS) and found genetic involvement, particularly mutations in the BICD2 gene, indicating the role of the muscular system in AIS etiology. The analysis also revealed significant enrichment in myosin-related and neuronal activity-related categories, reinforcing the suspected involvement of the neuronal and muscular systems in AIS and suggesting a possible role of DNA-binding activities in AIS physiopathology.
Article
Materials Science, Multidisciplinary
Xiaoqiang Liu, Shishir K. Pandey, Ji Feng
Summary: The crystal and electronic structure of silver difluoride show similarities to cuprates. It exhibits unconventional superconducting behavior under optimal electron doping, highlighting its importance in understanding high-TC phenomena.
Article
Multidisciplinary Sciences
Jason A. Wagoner, Ken A. Dill
Summary: Myosin II is a biomolecular machine responsible for muscle contraction. Multiple motors act cooperatively on a single actin filament, and filament backsliding is crucial for the speed and efficiency of muscle contraction. Evolutionary adaptations have reduced backsliding, optimizing the collective action of myosin II motors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Yuanyuan Xue, Xinde Hu, Daqi Wang, Di Li, Yige Li, Fang Wang, Mingqian Huang, Xi Gu, Zhijiao Xu, Jinan Zhou, Jinghan Wang, Renjie Chai, Jun Shen, Zheng-Yi Chen, Geng-Lin Li, Hui Yang, Huawei Li, Erwei Zuo, Yilai Shu
Summary: This study demonstrates the potential of in vivo genome editing as a therapeutic approach for treating genetic hearing loss, specifically in Myo6 mutation cases. The findings show that targeted editing of the MYO6 gene can ameliorate hearing loss and improve auditory function.