Editorial Material
Hematology
Daniela S. Krause
Summary: Yu et al. discovered a novel signaling pathway that leads to resistance to venetoclax, an increase in stem cell features, and a decrease in apoptosis in acute myeloid leukemia (AML).
Article
Oncology
Man Nie, Weicheng Ren, Xiaofei Ye, Mattias Berglund, Xianhuo Wang, Karin Fjorden, Likun Du, Yvonne Giannoula, Dexin Lei, Wenjia Su, Wei Li, Dongbing Liu, Johan Linderoth, Chengyi Jiang, Huijing Bao, Wenqi Jiang, Huiqiang Huang, Yong Hou, Shida Zhu, Gunilla Enblad, Mats Jerkeman, Kui Wu, Huilai Zhang, Rose-Marie Amini, Zhi-Ming Li, Qiang Pan-Hammarstrom
Summary: This study found that CD70 genetic alterations are associated with tumor occurrence and poor survival in diffuse large B-cell lymphoma (DLBCL). CD70 genetic changes result in a reduction in protein expression and CD27 binding, which impairs T cell priming. However, over-expression of CD70 protein is also associated with poor treatment response and advanced disease stage.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Hematology
Benedetto Bruno, Ralph Wasch, Monika Engelhardt, Francesca Gay, Luisa Giaccone, Mattia D'Agostino, Luis-Gerardo Rodriguez-Lobato, Sophia Danhof, Nico Gagelmann, Nicolaus Kroeger, Rakesh Popat, Niels W. C. J. van de Donk, Evangelos Terpos, Meletios A. Dimopoulos, Pieter Sonneveld, Hermann Einsele, Mario Boccadoro
Summary: CAR-T cell therapy has shown remarkable potential in treating refractory B-cell malignancies, with BCMA-targeted CAR-T demonstrating promising results. However, unapproved therapies still face challenges in long-term outcomes, toxicities, treatment resistance, and complication management.
Article
Oncology
Tomas Jelinek, Renata Bezdekova, David Zihala, Tereza Sevcikova, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondrej Venglar, Veronika Kapustova, Tereza Popkova, Ludmila Muronova, Zuzana Chyra, Matous Hrdinka, Michal Simicek, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hajek
Summary: This study reveals that >= 2% circulating plasma cells (CTCs) can serve as a biomarker of hidden primary plasma cell leukemia (PCL) and supports the use of flow cytometry to assess CTC levels during the diagnostic workup of multiple myeloma (MM).
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Diana Cenariu, Eva Fischer-Fodor, Adrian Bogdan Tigu, Andrea Bunea, Piroska Virag, Maria Perde-Schrepler, Vlad-Alexandru Toma, Andrei Mocan, Ioana Berindan-Neagoe, Adela Pintea, Gianina Crisan, Mihai Cenariu, Alma Maniu
Summary: The study reveals the selective activity of zeaxanthin from L. barbarum on skin cells, influencing specific signaling pathways and markers related to oxidative stress. This suggests the potential use of zeaxanthin as a cytoprotective agent in normal skin and raises questions about its application in anti-tumor therapy.
Article
Oncology
Mariam Oladejo, Hong-My Nguyen, Laurence Wood
Summary: Molecular biomarkers interacting with vascular and immune compartments have a significant role in the progression of solid malignancies. CD105, a component of the TGF-β signaling cascade, has been extensively studied for its angiogenic role in various cancers. However, in renal cell carcinoma (RCC), CD105 has a diverse expression profile and multiple functions on tumor cells, tumor vasculature, and immune system components. This review summarizes the recent evidence and findings of the multifunctional roles of CD105 in angiogenesis and immunomodulation in different subtypes of RCC, with a specific emphasis on clear cell RCC. The review also provides an update on the preclinical and clinical applications of CD105 as a therapeutic platform in RCC.
Article
Oncology
Nadine Benhamouda, Ikuan Sam, Nicolas Epaillard, Alain Gey, Letuan Phan, Hang Phuong Pham, Nadege Gruel, Antonin Saldmann, Josephine Pineau, Milena Hasan, Valentin Quiniou, Camille Nevoret, Virginie Verkarre, Valentina Libri, Sebastien Mella, Clemence Granier, Chloe Broudin, Patrice Ravel, Eleonore De Guillebon, Laetitia Mauge, Dominique Helley, Bernd Jabla, Nathalie Chaput, Laurence Albiges, Sandrine Katsahian, Julien Adam, Arnaud Mejean, Olivier Adotevi, Yann A. Vano, Stephane Oudard, Eric Tartour
Summary: This study found that the interaction between CD70 and CD27 in clear-cell renal cell carcinoma is associated with T-cell dysfunction in the tumor microenvironment. High levels of soluble CD27 (sCD27) were predictive of poor overall survival in patients treated with anti-programmed cell death protein 1 therapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou, Liang Huang
Summary: This pilot study investigated the safety and efficacy of ASCT combined with CAR30 T-cell infusion in relapsed/refractory CD30(+) lymphoma patients. The results showed that this treatment approach is well-tolerated and highly effective.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Megan E. Dempsey, Olivia Woodford-Berry, Eric M. Darling
Summary: Researchers have developed a method to characterize antibody removal timelines for any cell-antibody combination, allowing for the study of broad mechanisms of antibody removal. The specific antibody tested determined the removal mechanism, while the cell type influenced the removal timelines. This method is relevant for quantifying an initial timeframe for uninhibited use of antibody-labeled cells.
CELLULAR AND MOLECULAR BIOENGINEERING
(2021)
Article
Hematology
Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth
Summary: Cell-free mtDNA is elevated in the peripheral blood and BM of patients with myeloma. Myeloma-derived mtDAMPs remodel the BM microenvironment through STING activation. These findings provide insights into the mechanism and functional consequences of mtDAMPs in myeloma disease progression.
Article
Integrative & Complementary Medicine
Onyemaechi Okolo, Betsy C. Wertheim, Ashley Larsen, Nathan W. Sweeney, Jennifer M. Ahlstrom, Krisstina Gowin
Summary: This study investigated the use and efficacy of integrative medicine in patients with plasma cell disorders. The survey found that most patients participated in various integrative medicine modalities, though they felt uncomfortable discussing them with their oncologist. Some integrative medicine practices were associated with quality of life, but more research is needed to evaluate the efficacy of individual interventions.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Review
Oncology
Urvi A. Shah, Richa Parikh, Francesca Castro, Matteo Bellone, Alexander M. Lesokhin
Summary: This article provides a detailed review of the role of dietary and microbiome factors in the pathogenesis of multiple myeloma (MM) and their impact on outcomes. The findings suggest that dietary and lifestyle interventions may have significant implications for preventing and improving the quality of life of MM patients.
Article
Biotechnology & Applied Microbiology
Yang Wu, Dan Chen, Ya Lu, Shu-Chen Dong, Rong Ma, Wei-yan Tang, Jian-qiu Wu, Ji-Feng Feng, Jian-Zhong Wu
Summary: The study demonstrated an effective CAR-T cell treatment for CD30-positive PTCL tumors by using CD30 CAR T cells to suppress tumor growth.
CANCER GENE THERAPY
(2022)
Article
Dermatology
Tabea Schlemeyer, Denise Ohnezeit, Sanamjeet Virdi, Christian Korner, Samira Weisselberg, Sarah Starzonek, Udo Schumacher, Adam Grundhoff, Daniela Indenbirken, Silvia Albertini, Nicole Fischer
Summary: This study investigates the role of Merkel cell polyomavirus oncoproteins in metastasis and finds that sT protein specifically affects selectin ligand binding and processing, thus influencing tumor metastasis events and immune recognition. Additionally, sT regulates the surface antigen CD47, inhibiting phagocytosis by macrophages. Targeting CD47 may be a promising therapeutic approach for Merkel cell carcinoma.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Mariam Oladejo, Hong-My Nguyen, Hannah Seah, Arani Datta, Laurence M. Wood
Summary: CD105 is a transmembrane protein highly expressed on endothelial cells, and contributes to tumor angiogenesis and progression. It is also expressed by tumor cells in certain cancers, such as renal cell carcinoma, where it is associated with stem cell-like properties. However, the role of tumor-expressed CD105 in the anti-tumor immune response and tumor microenvironment is still unclear.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Letter
Hematology
Maria Siddiqui, Sergej Konoplev, Ghayas Issa, Hagop Kantarjian, Naval Daver, Farhad Ravandi, Tapan Kadia, Guilin Tang, Sa A. Wang, Beenu Thakral, L. Jeffrey Medeiros, Olga Pozdnyakova, Sherry Pierce, Guillermo Montalban-Bravo, Kelly Chien, Danielle Hammond, Koji Sasaki, Guillermo Garcia-Manero, Robert P. Hasserjian
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Pathology
Ying-Ren Chen, Shan-Chi Yu, Ren-Ching Wang, Chih-Ling Lee, Hsiang-Lin Song, L. Jeffrey Medeiros, Chung-Tai Yue, Kung-Chao Chang
Summary: This study investigated 55 lymph node biopsy specimens and found that increased IgG4(+) plasma cells can be a nonspecific finding or a manifestation of IgG4-related disease. The study also found minimal differences between patients with lymphadenopathy who did and did not exhibit other manifestations of IgG4-related disease.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Yi Wang, Andres E. Quesada, Zhuang Zuo, L. Jeffrey Medeiros, C. Cameron Yin, Shaoying Li, Jie Xu, Gautam Borthakur, Yisheng Li, Chao Yang, Yasmin Abaza, Juehua Gao, Xinyan Lu, M. James You, Yizhuo Zhang, Pei Lin
Summary: Through a study of 107 patients with NPM1-mutated AML treated with risk-adapted therapy, it was found that patients with MDS-related gene mutations had a similar MMD rate compared to those without the mutations. However, the former group had a higher relapse rate and shorter progression-free survival.
Article
Oncology
Lianqun Qiu, Sa A. Wang, Guilin Tang, Wei Wang, Pei Lin, Jie Xu, C. Cameron Yin, Mahsa Khanlari, L. Jeffrey Medeiros, Shaoying Li
Summary: The six-point scoring system showed a sensitivity of 100% in distinguishing blastoid-HGBL and B-ALL. Using both scoring systems together improves the accuracy of classification of blastoid B-cell neoplasms to 99%.
Article
Biology
Zhuang Zuo, L. Jeffrey Medeiros, Sofia Garces, Mark J. Routbort, Chi Young Ok, Sanam Loghavi, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Guillermo Garcia-Manero, Kelly L. S. Chien, Keyur S. P. Patel, Rajyalakshmi Luthra, C. Cameron Yin
Summary: The genetic landscape of myeloid neoplasms has been elucidated by next-generation sequencing, revealing that multiple gene mutations are present in most cases. Understanding the patterns and interactions between these mutations can improve diagnosis and prognosis. SF3B1 and PHF6 mutations are known to have cooperative or mutually exclusive effects in the pathogenesis of myeloid neoplasms. This study reports the clinicopathologic and molecular features of 21 cases with double SF3B1 and PHF6 mutations, highlighting their rarity but presence in various myeloid neoplasms and their roles in early events and disease progression.
Article
Cell Biology
Mario L. Marques-Piubelli, Do Hwan Kim, L. Jeffrey Medeiros, Wei Lu, Khaja Khan, Lorena Isabel Gomez-Bolanos, Saxon Rodriguez, Edwin R. Parra, Chi Young Ok, Akanksha Aradhya, Luisa M. Solis, Yago L. Nieto, Raphael Steiner, Sairah Ahmed, Francisco Vega
Summary: CAR-T cell therapy results in decreased CD30 expression in refractory/relapsed classical Hodgkin lymphoma (CHL) patients, but certain levels of CD30 expression are still detectable.
Review
Pathology
Ling Zhang, Bijal Shah, Yumeng Zhang, Hammad Tashkandi, Wenbin Xiao, Sebastian Fernandez-Pol, Maria Vergara-Lluri, Mohammad Hussaini, Jinming Song, Jeffrey Lancet, Lynn Moscinski, Seongseok Yun, Chuanyi M. Lu, L. Jeffrey Medeiros, Guilin Tang
Summary: JAK2 rearrangement (JAK2-R) is a rare subtype of acute lymphoblastic leukemia (ALL) and mainly occurs in adult males, with a B-cell lineage. Patients with JAK2-R ALL often present with marked leukocytosis and hypercellular bone marrow. Survival rates for JAK2-R ALL are relatively low compared to other subtypes of ALL. The absence of eosinophilia and bone marrow fibrosis differentiate JAK2-R ALL from other myeloid/lymphoid neoplasms.
Article
Pathology
Ji Yuan, Hui Liu, Shimin Hu, Roberto N. Miranda, Xinjie Xu, Michael G. Bayerl, Cody J. Artymiuk, Holly Berg, Rebecca L. King, Min Shi, Rong He, David Viswanatha, L. Jeffrey Medeiros, Ellen D. Mcphail
Summary: This study reports 5 adult patients with FL and FL/DLBCL with concurrent BCL2 and IRF4 rearrangements. The clinicopathologic and mutational features of these patients are more akin to FL and DLBCL, and should not be characterized as large B-cell lymphoma with IRF4 rearrangement.
Meeting Abstract
Medicine, Research & Experimental
Fnu Aakash, L. Jeffrey Medeiros, Lianqun Qiu, Jie Xu, Pei Lin, Roberto Miranda, Beenu Thakral, M. James You, Shaoying Li
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Okechukwu Nwogbo, Francis San Lucas, Hyvan Dang, Mario L. Marques-Piubelli, Amy Ayers, Hector Alvarez, Rajyalakshmi Luthra, Loretta Nastoupil, Christopher Flowers, L. Jeffrey Medeiros, Keyur Patel, Francisco Vega
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Daniel Rivera, Shuyu E, Wei Cui, Qian-Yun Zhang, Rajan Dewar, Huan-You Wang, Zhihong Hu, Wei Wang, L. Jeffrey Medeiros, Shimin Hu
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
E. Shuyu, Meng Liu, Hong Fang, Wei Wang, Guilin Tang, L. Jeffrey Medeiros, Shimin Hu
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
E. Shuyu, L. Jeffrey Medeiros, Shaoying Li, Sa Wang, Pei Lin, Wei Wang, Swami Iyer, Luis Malpica-Castillo, C. Cameron Yin, Guilin Tang, Zhenya Tang, M. James You, Jie Xu
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Zhenya Tang, Guilin Tang, Gokce Toruner, Su Yang, Wei Wang, Hong Fang, Hanadi El Achi, Beenu Thakral, Jie Xu, C. Cameron Yin, M. James You, Roberto Miranda, Joseph Khoury, L. Jeffrey Medeiros
LABORATORY INVESTIGATION
(2023)
Article
Biology
Hillary P. Esplen, Richard K. Yang, Awdhesh Kalia, Zhenya Tang, Guilin Tang, L. Jeffrey Medeiros, Gokce A. Toruner
Summary: There is a strong correlation between recurrent somatic copy number alterations (SCNAs) and gene expression levels in high-grade ovarian serous carcinoma (HGOSC). Several genes with highly correlated SCNA and mRNA expression levels are associated with clinicopathological parameters such as age, disease stage, and survival.
