Article
Biology
Anna Leabourn Boss, Tanvi Damani, Tayla J. Wickman, Larry W. Chamley, Joanna L. James, Anna E. S. Brooks
Summary: Researchers used flow cytometry to phenotypically characterize mesenchymal cells in the placenta and identified four distinct subsets. They also discovered that some mesenchymal cells undergo phenotypic convergence in ex-vivo culture. This study highlights the importance of detailed cell phenotyping for optimizing therapeutic capacity and ensuring the use of relevant cells in functional assays.
Review
Cell Biology
Qianmin Gao, Lipeng Wang, Sicheng Wang, Biaotong Huang, Yingying Jing, Jiacan Su
Summary: Bone marrow mesenchymal stromal cells are a group of heterogeneous cells consisting of multipotent stem cells, including osteochondral and adipocyte progenitors. Recent studies have identified new subgroups of BMSCs and clarified their roles in normal and pathological conditions. Furthermore, key regulators and mechanisms controlling the fate of BMSCs have been revealed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gregorie Lebeau, Franck Ah-Pine, Matthieu Daniel, Yosra Bedoui, Damien Vagner, Etienne Frumence, Philippe Gasque
Summary: Mesenchymal stem cells (MSCs) play a critical role in response to infection and can remove cell debris, regulate immune activities, control pathogens, and contribute to tissue remodeling. However, chronic infection and inflammation can affect the functions and immune regulatory activities of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Anja Lena Thiebes, Franziska E. Uhl, Marie Hauser, Christian G. Cornelissen, Stefan Jockenhoevel, Daniel J. Weiss
Summary: The study evaluated the feasibility of spraying MSCs using endoscopic atomization devices and found high survival rates, as well as the ability to induce cell differentiation. This suggests that endoscopic atomization may have a potential role in pulmonary MSC-based cell therapies.
Review
Immunology
Julia Sbierski-Kind, Nicholas Mroz, Ari B. Molofsky
Summary: Perivascular niches are specialized microenvironments where stromal and immune cells interact with vasculature to monitor tissue status. Adventitial perivascular niches, particularly adventitial fibroblasts (AFs), play a significant role in regulating vascular integrity and supporting the activation of immune cells. Pericytes, on the other hand, support microvascular capillaries and organ-specific parenchymal cells in perivascular tissue immune niches.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Cell Biology
Beverly Brooks, Dominique Ebedes, Ahsan Usmani, Joaquin Vega Gonzales-Portillo, Daniel Gonzales-Portillo, Cesario Borlongan
Summary: Ischemic brain injury is a major cause of death worldwide with limited treatment options. Stem cell-based regenerative therapies, specifically mesenchymal stromal cells, show promise in stroke treatment, but further research is needed to fully understand their cell function.
Article
Cell & Tissue Engineering
Jiajia Xu, Yiyun Wang, Mario A. Gomez-Salazar, Ginny Ching-Yun Hsu, Stefano Negri, Zhao Li, Winters Hardy, Lijun Ding, Bruno Peault, Aaron W. James
Summary: Mesenchymal progenitor cells are widely distributed in perivascular niches, particularly in the tunica adventitia of mammalian tissues. Adventitial cells demonstrate strong osteogenic potential and may play a significant role in future tissue repair and bioengineering efforts.
Article
Dentistry, Oral Surgery & Medicine
J. F. Liang, J. Wang, Y. T. Ji, Q. Zhao, L. T. Han, R. J. Miron, Y. F. Zhang
Summary: Stem and progenitor cells play crucial roles in the development and maintenance of teeth and bone. Recent studies have identified dental tissue-derived stem cells that resemble bone marrow-derived mesenchymal stem cells. These dental stem cells have similar characteristics to skeletal stem cells and have the potential for dental regeneration. This discovery provides new insights into the treatment of dental diseases.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Immunology
Faten A. M. Abo-Aziza, Basma M. Wasfy, Sanaa M. R. Wahba, Sahar S. Abd-Elhalem
Summary: There is limited research on the biological relationship between myeloid-derived suppressor cells (MDSCs) and mesenchymal stem cells (MSCs). This study examined their cooperation in a rat model of adjuvant-induced arthritis (AIA). Results showed that MDSCs played various roles in autoimmunity and MSCs administration improved cytokine levels, suggesting their potential application in immunotherapy for arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalie Vallant, Bynvant Sandhu, Karim Hamaoui, Maria Prendecki, Charles Pusey, Vassilios Papalois
Summary: This study compared the paracrine effects of MSC supernatants from different age and genotype sources on macrophages, revealing distinct patterns of inflammatory marker expression. These findings are crucial for preclinical and clinical studies utilizing MSCs for inflammation and allo-response mitigation in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Mariam F. Farid, Yara S. Abouelela, Noha A. E. Yasin, Asmaa K. Al-Mokaddem, Abdelbary Prince, Marwa A. Ibrahim, Hamdy Rizk
Summary: This study aimed to evaluate the regenerative capacity of low-level laser-activated SVF in an MS cat model. The results showed that SVF treatment significantly improved locomotion activity, BBB scores, lesion extent, and expression of neurotrophic factors. SVF treatment also led to an increase in oligodendrocyte transcription factor and myelin basic protein, and a reduction in apoptosis and axonal degeneration, demonstrating its potential for remyelination and regeneration in MS.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Meryem Ouzin, Gesine Kogler
Summary: Mesenchymal stromal cells are widely used in regenerative medicine and translational research, but their heterogeneity and the lack of understanding of their molecular mechanisms pose challenges for clinical applications. This review focuses on the heterogeneity aspects related to tissue source and developmental origin, emphasizing the importance of generating homogeneous products for clinical use.
Review
Neurosciences
F. Ah-Pine, M. Khettab, Y. Bedoui, Y. Slama, M. Daniel, B. Doray, P. Gasque
Summary: This review summarizes the potential roles of mesenchymal stromal cells in the context of glioblastoma and provides novel research avenues to better understand this lethal disease.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Evan L. Dray, Carey G. Ousley, Daniel B. McKim
Summary: This study systematically investigated methods for bone marrow stromal cell dissociation, finding that Dispase II + DNase combined with magnetic sorting significantly increased the yield of endothelial cells and mesenchymal stromal cells.
MOLECULAR IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yoshitaka Iso, Sayaka Usui, Hiroshi Suzuki
Summary: The aim of this study was to investigate the pro-angiogenic potential of skeletal muscle mesenchymal stem/stromal cells (mMSCs). The results showed that PDGFR-alpha positive mMSCs secreted VEGF and hepatocyte growth factor, inducing endothelial tube formation and promoting capillary growth. Epo stimulation enhanced phosphorylation and cellular proliferation in mMSCs, leading to improved perfusion recovery and capillary growth in the ischemic limbs.
