期刊
CYTOMETRY PART A
卷 83A, 期 1, 页码 18-26出版社
WILEY
DOI: 10.1002/cyto.a.22069
关键词
mesenchymal stem cells; elite model; iPS cells; adult stem cells
资金
- Grants-in-Aid for Scientific Research [23124501, 23390060, 25670135, 24790188, 23659145] Funding Source: KAKEN
Induced pluripotent stem (iPS) cells have attracted a great deal of attention, although the mechanism by which they are generated is still not fully understood. Currently, two theories, the stochastic and elite models, have been proposed. Some reports provide theoretical support for the stochastic model. Other reports, however, support the elite model. For example, some human fibroblasts, such as Multilineage-differentiating stress enduring ( Muse) cells, are reported to be pluripotent and a primary source of iPS cells. Thus, the mechanism of iPS cell generation continues to be debated. In this review, we discuss the properties of the original cell source, such as the components of the original populations and the potential of each population to become iPS cells, and further discuss the implications of the two theories for iPS cell research. (C) 2012 International Society for Advancement of Cytometry
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