期刊
CYTOMETRY PART A
卷 75A, 期 1, 页码 4-13出版社
WILEY
DOI: 10.1002/cyto.a.20665
关键词
VSELs; Oct-4; pluripotent stem cells; small stem cells; ImageStream
资金
- NATIONAL CANCER INSTITUTE [R01CA106281] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA106281, R01 CA106281-01A2, R01 CA10628] Funding Source: Medline
This review summarizes information regarding the rare population of very small embryonic-like stem cells (VSELs) that has been identified in adult tissues, emphasizing both their unique morphological features and potential biological significance. We focus oil their pluripotent nature and expression of markers characteristic for embryonic stem cells (ESCs), epiblast (EP)SCs, and primordial germ cells (PGCs). Furthermore, we will discuss their rank in the developmental hierarchy of the SC compartment as well as their relationship to other bone in marrow-derived, primitive, nonhematopoietic SCs including: (i) endothelial progenitor cells (EPCs); (ii) mesenchymal (M)SCs; (iii) multipotent adult progenitor cells (MAPCs); (iv) marrow-isolated adult multilineage inducible (MIAMIs) cells; (v) multipotent adult (MA)SCs; and (vi) OmniCytes. We will also present different populations of very small SCs that have been recently described in the literature (e.g., spore-like cells and Lin(-)/ALDH(high) long-term repopulating hematopoietic SCs). (C) 2008 International Society for Advancement of Cytometry
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