期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 25, 期 5, 页码 621-628出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.05.004
关键词
Negative-strand RNA virus; Genome segmentation; RIG-I-like receptors; Panhandle; Viral countermeasures
资金
- Deutsche Forschungsgemeinschaft [We 2616/7-1, SFB 593, SFB 1021]
- Forschungsforderung gem. 2 Abs. 3 Kooperationsvertrag Universitatsklinikum Giessen und Marburg
- Leibniz Graduate School for Emerging viral diseases (EIDIS)
Negative strand RNA viruses with a nonsegmented genome (ns-NSVs) or a segmented genome (s-NSVs) are an important source of human and animal diseases. Survival of the host from those infections is critically dependent on rapidly reacting innate immune responses. Two cytoplasmic RNA helicases, RIG-I and MDA5 (collectively termed RIG-I-like receptors, RLRs), are essential for recognizing virus-specific RNA structures to initiate a signalling cascade, resulting in the production of the antiviral type I interferons. Here, we will review the current knowledge and views on RLR agonists, RLR signalling, and the wide variety of countermeasures ns-NSVs and s-NSVs have evolved. Specific aspects include the consequences of genome segmentation for RLR activation and a discussion on the physiological ligands of RLRs. (C) 2014 Elsevier Ltd. All rights reserved.
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