期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 22, 期 3, 页码 141-147出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2011.05.002
关键词
MicroRNA-155; Immune cells; Autoimmune diseases
资金
- National Natural Science Foundation of China [30830089]
- Anhui Provincial Natural Science Foundation [11040606M183]
MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous miR-155 has been implicated in the pathogenesis of human cancers. Recently, aberrant expression of miR-155 was observed in many autoimmune conditions, including rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). Moreover, functional analysis demonstrated that miR-155 has powerful regulatory potential in a wide variety of immune cells through targeting specific mRNAs. Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity. (C) 2011 Elsevier Ltd. All rights reserved.
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