期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 3, 页码 251-258出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.05.002
关键词
TWEAK; Fn14 receptor; Cytokines
资金
- ISCIIIRETICS REDINREN [FIS 06/0046, 06/0016]
- RECAVA [RD06/0014/0035]
- MEC [SAF03/884, SAF2007-60896, SAF2007/63648]
- Sociedad Espanola de Nefrologia [S2006/GEN-0247]
- Fondo de Investigaciones Sanitarias [CP04/00060]
- Comunidad de Madrid and FRACAM [S-BIO 0283/2006]
TWEAK is a cytokine of the TNF superfamily that activates the Fn14 receptor. TWEAK may regulate cell proliferation, cell death, cell differentiation, angiogenesis and inflammation. The expression of TWEAK and Fn14 is increased during vascular and renal injury. Inflammatory cytokines increase Fn14 receptor expression in tubular and vascular smooth muscle cells. Moreover, TWEAK induces tubular cell apoptosis under proinflammatory conditions. TWEAK itself contributes to renal and vascular inflammation by promoting chemokine and inflammatory cytokine secretion. Confirmation of its role in acute kidney injury and atherosclerotic lesions formation came from functional studies in experimental animal models. The available evidence suggests that TWEAK might be a target for therapeutic intervention in renal and vascular injury and its role in different forms of tissue damage should be further explored. (C) 2009 Elsevier Ltd. All rights reserved.
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