Review
Clinical Neurology
Mahsa Vafaei Mastanabad, Aref Nooraei, Mahgol Sadat Hassan Zadeh Tabatabaei, Amir Akbari Fakhrabadi, Faria Jafarzadeh
Summary: This article introduces the basics of amyotrophic lateral sclerosis (ALS) and G-CSF, and comprehensively reviews the applications of G-CSF in clinical and pre-clinical studies, emphasizing the significant efficacy in pre-clinical studies and the failure to replicate the results in clinical studies.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Siw Johannesen, J. Russell Huie, Bettina Budeus, Sebastian Peters, Anna M. Wirth, Sabine Iberl, Tina Kammermaier, Ines Kobor, Eva Wirkert, Sabrina Kuspert, Marlene Tahedl, Jochen Grassinger, Tobias Pukrop, Armin Schneider, Ludwig Aigner, Wilhelm Schulte-Mattler, Gerhard Schuierer, Winfried Koch, Tim-Henrik Bruun, Adam R. Ferguson, Ulrich Bogdahn
Summary: The study focuses on early assessment of filgrastim treatment effects in ALS patients through survival modeling and biomarkers. Individualized long-term filgrastim treatment showed positive effects on disease progression and survival in a small cohort of ALS patients, with model-based biomarker response classification allowing early identification of strong treatment responders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Radhika Khosla, Manjari Rain, Suresh Sharma, Akshay Anand
Summary: ALS is a degenerative disorder of motor neurons, and early diagnosis is crucial for predicting the disease and its progression. The study presents a predictive statistical model for ALS using plasma and CSF biomarkers, showing good validity, sensitivity, and specificity.
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Environmental Sciences
Fan Wu, Angela M. Malek, Jeanine M. Buchanich, Vincent C. Arena, Judith R. Rager, Ravi K. Sharma, John E. Vena, Todd Bear, Evelyn O. Talbott
Summary: This study aimed to investigate the risk factors for ALS and found that high exposure to vinyl chloride, 2,4-dinitrotoluene, cyanide, cadmium, and carbon disulfide was associated with an increased risk of ALS. Additionally, residential air selenium showed an inverse association with ALS, while exposure to organic/chlorinated solvents was associated with ALS. These findings highlight the importance of ongoing surveillance of potential exposures for at-risk populations.
ENVIRONMENTAL RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Katarina Maksimovic, Mohieldin Youssef, Justin You, Hoon-Ki Sung, Jeehye Park
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons, leading to muscle weakness, paralysis, and eventual death. Recent research has shown that ALS is not only limited to motor neurons, but also involves systemic metabolic dysfunction. This review examines the metabolic dysfunction in ALS at various levels, including muscle tissue, adipose tissue, liver, pancreas, and the central nervous system. It also discusses the future prospects of metabolic research in ALS and potential treatment options.
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Review
Clinical Neurology
Georgiana Soares Leandro, Mario Emilio Teixeira Dourado Junior, Glauciane Costa Santana, Luan Samy Xavier Dantas
Summary: The main coping strategy used by ALS patients is seeking social support, while Confrontive coping and Distancing are less commonly mentioned. The coping strategies of ALS patients do not seem to focus on emotions or stress-triggering problems, and age and gender do not modify the chosen strategy.
JOURNAL OF NEUROLOGY
(2022)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Biotechnology & Applied Microbiology
Xu-Dong Wang, Wei-Jia Yu, Jia-Hui Liu, Jie Du, Kang-Nan Chen, Qin-Qin Hu, Wen-Long Sun, Guo-Qing Ying
Summary: This study investigated a long-acting strategy for modifying rhG-CSF with C15-MAL, which significantly increased its serum half-life and showed potential as a novel drug candidate. The modified C15-rhG-CSF retained its bioactivity and demonstrated improved efficacy compared to other existing treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Christina N. Fournier
Summary: Thoughtful clinical trial design and the use of statistical enrichment techniques are crucial for efficient therapeutic development in ALS research. Further advancements in biomarker development are needed to confirm target engagement in treatment trials. Involving patients with ALS as advisors and advocates can strengthen clinical trial design and retention. Respect for patient autonomy and improving access to experimental treatments are important challenges in ALS therapeutic development.
Review
Medicine, General & Internal
Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott
Summary: The gut microbiome may play a significant role in the pathogenesis of ALS, with research indicating that microbial changes can affect disease outcomes. Variability in gut microbiota between individuals may explain the different disease outcomes seen in ALS patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Koji Tokunaga, Chikara Maeda, Sadao Horikawa, Ryuko Nakayama, Shigeaki Umeoka
Summary: We present a case of G-CSF-producing inflammatory myofibroblastic tumor in a 71-year-old man with multiple pleural masses and pulmonary hilar lymph nodes swelling. Imaging studies showed focal FDG uptake in the thoracic masses and diffuse uptake in the bone marrow. Based on pathology and elevated serum G-CSF level, the patient was diagnosed with G-CSF-producing inflammatory myofibroblastic tumor. Early and accurate diagnosis is crucial due to the aggressive clinical course of G-CSF-producing tumors.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Sebastian Michels, Deborah Kurz, Angela Rosenbohm, Raphael S. Peter, Steffen Just, Hansjörg Baezner, Axel Boertlein, Christian Dettmers, Hans-Jürgen Gold, Andreas Kohler, Markus Naumann, Peter Ratzka, Albert C. Ludolph, Dietrich Rothenbacher, Gabriele Nagel, Johannes Dorst
Summary: This large-scale population-based case-control study examined the associations between blood lipid levels and the onset and prognosis of ALS. The results showed a positive correlation between high total cholesterol levels and the risk of ALS. Furthermore, higher levels of HDL and LDL cholesterol were associated with higher mortality in ALS patients, whereas higher triglyceride levels were associated with lower mortality.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jinming Han, Violeta Chitu, E. Richard Stanley, Zbigniew K. Wszolek, Virginija Danylaite Karrenbauer, Robert A. Harris
Summary: This review article summarizes the recent advances in the use of CSF-1R inhibitors for treating neurodegenerative diseases and discusses potential challenges for clinical application.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Clinical Neurology
Albert C. Ludolph, Joachim Schuster, Johannes Dorst, Luc Dupuis, Jens Dreyhaupt, Jochen H. Weishaupt, Jan Kassubek, Ulrike Weiland, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Berthold Schrank, Matthias Boentert, Alexander Emmer, Andreas Hermann, Daniel Zeller, Johannes Prudlo, Andrea S. Winkler, Torsten Grehl, Michael T. Heneka, Siw Wollebaek Johannesen, Bettina Goericke
Article
Clinical Neurology
Ernst Hund, Arnt V. Kristen, Michaela Auer-Grumbach, Christian Geber, Frank Birklein, Wilhelm Schulte-Mattler, Claudia Sommer, Hartmut Schmidt, Christoph Roecken
AKTUELLE NEUROLOGIE
(2018)
Article
Clinical Neurology
Anna M. Wirth, Andrei Khomenko, Dobri Baldaranov, Ines Kobor, Ohnmar Hsam, Thomas Grimm, Siw Johannesen, Pm-Henrik Bruun, Wilhelm Schulte-Mattler, Mark W. Greenlee, Ulrich Bogdahn
FRONTIERS IN NEUROLOGY
(2018)
Reprint
Clinical Neurology
Christian Bischoff, Wilhelm Schulte-Mattler, Ulf Schminke
KLINISCHE NEUROPHYSIOLOGIE
(2019)
Review
Clinical Neurology
Wilhelm Schulte-Mattler, Christian Bischoff
KLINISCHE NEUROPHYSIOLOGIE
(2019)
Editorial Material
Clinical Neurology
R. Weisser, S. Jalili, E. Haen, W. Schulte-Mattler, T. C. Wetter
Article
Engineering, Biomedical
Eric Elzenheimer, Helmut Laufs, Wilhelm Schulte-Mattler, Gerhard Schmidt
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2020)
Review
Clinical Neurology
Maike F. Dohrn, Michaela Auer-Grumbach, Ralf Baron, Frank Birklein, Fabiola Escolano-Lozano, Christian Geber, Nicolai Grether, Tim Hagenacker, Ernst Hund, Juliane Sachau, Matthias Schilling, Jens Schmidt, Wilhelm Schulte-Mattler, Claudia Sommer, Markus Weiler, Gilbert Wunderlich, Katrin Hahn
Summary: Hereditary transthyretin amyloidosis is caused by pathogenic variants in the TTR gene, leading to severe sensorimotor and autonomic polyneuropathy. Three approved drugs aim to prevent amyloid deposition by stabilizing TTR protein or degrading its mRNA. Early recognition of disease onset and progression is essential, with therapy based on individual symptoms and constant monitoring for optimization.
JOURNAL OF NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Markus C. Fleisch, Werner Bader, Kai Balzer, Luisa Bennefeld, Carsten Boeing, Dorothee Bremerich, Paul Gass, Verena Geissbuehler, Martin C. Koch, Monika J. Nothacker, Klaus Pietzner, Stefan P. Renner, Thomas Roemer, Stephan Roth, Florian Schuetz, Wilhelm Schulte-Mattler, Jalid Sehouli, Kristina Lippach, Karl Tamussino, Alexander Teichmann, Clemens Tempfer, Marc Thill, Hans-Rudolf Tinneberg, Konstantinos Zarras
Summary: The guideline aims to summarize the literature on preventing positioning injuries and provide relevant statements and recommendations. Through a consensus process involving an interdisciplinary group of experts, consensus was reached on the prevention, diagnosis, and treatment of positioning injuries.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Article
Clinical Neurology
Siw Johannesen, J. Russell Huie, Bettina Budeus, Sebastian Peters, Anna M. Wirth, Sabine Iberl, Tina Kammermaier, Ines Kobor, Eva Wirkert, Sabrina Kuspert, Marlene Tahedl, Jochen Grassinger, Tobias Pukrop, Armin Schneider, Ludwig Aigner, Wilhelm Schulte-Mattler, Gerhard Schuierer, Winfried Koch, Tim-Henrik Bruun, Adam R. Ferguson, Ulrich Bogdahn
Summary: The study focuses on early assessment of filgrastim treatment effects in ALS patients through survival modeling and biomarkers. Individualized long-term filgrastim treatment showed positive effects on disease progression and survival in a small cohort of ALS patients, with model-based biomarker response classification allowing early identification of strong treatment responders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Wilhelm J. Schulte-Mattler
Summary: The knowledge points for the EMG certificate of the DGKN were last updated 10 years ago with only minor changes. This article attempts to show what has changed, what is new, and what has been left behind in EMG practice over the past 30 years.
KLINISCHE NEUROPHYSIOLOGIE
(2021)
Editorial Material
Clinical Neurology
Wilhelm Schulte-Mattler
KLINISCHE NEUROPHYSIOLOGIE
(2020)
Article
Engineering, Biomedical
Eric Elzenheimer, Helmut Laufs, Wilhelm Schulte-Mattler, Gerhard Schmidt
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Meeting Abstract
Clinical Neurology
Siw Johannesen, Bettina Budeus, Sebastian Peters, Sabine Iberl, Anne-Louise Meyer, Eva Wirkert, Tim-Henrik Bruun, Wilhelm Schulte-Mattler, Armin Schneider, Ulrich Bogdahn
Meeting Abstract
Clinical Neurology
Siw Johannesen, Tim-Henrik Bruun, Bettina Budeus, Sebastian Peters, Anne-Louise Meyer, Ines Kobor, Ohnmar Hsam, Anna-Maria Wirth, Wilhelm Schulte-Mattler, Sabine Klatt, Ulrich Bogdahn
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.