Article
Oncology
Jhih-Yun Ho, Hsin-Ying Lu, Hsing-Hsien Cheng, Yu-Chieh Kuo, Yu-Lin Amy Lee, Chia-Hsiung Cheng
Summary: The study showed that higher UBE2S expression in lung adenocarcinomas leads to increased binding with I kappa B alpha to activate NF-kappa B signaling and promote adenocarcinoma cell metastasis. UBE2S may serve as a potential therapeutic target for lung adenocarcinomas.
Article
Immunology
Kristin Roseth Aass, Synne Stokke Tryggestad, Robin Mjelle, Martin H. H. Kastnes, Tonje Marie Vikene Nedal, Kristine Misund, Therese Standal
Summary: Multiple myeloma is a type of cancer characterized by the accumulation of malignant plasma cells in the bone marrow. Interleukin-32 (IL-32), a pro-inflammatory cytokine, is expressed in a subgroup of multiple myeloma patients and has been shown to promote the proliferation and survival of cancer cells. This study demonstrates that activation of Toll-like receptors (TLRs) can induce the expression of IL-32 in multiple myeloma cells through NF kappa B activation. The upregulation of TLR genes in individual patients, particularly those sensing bacterial components, coincides with an increase in IL-32 expression, suggesting that infections can induce the expression of this pro-tumorigenic cytokine in multiple myeloma patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yang Wang, Jing Zhang, Yang-Jia Li, Nan-Nan Yu, Wan-Ting Liu, Jun-Ze Liang, Wen Wen Xu, Zheng-Hua Sun, Bin Li, Qing-Yu He
Summary: The study identified MEST as a key regulator of invasion and metastasis in lung cancer, promoting cellular metastasis by activating the NF-kappa B signaling pathway. MEST interacts with VCP to coordinate the pathway, and high expressions of MEST and VCP are associated with poor survival in lung cancer patients. Targeting the MEST/VCP/I kappa B alpha/NF-kappa B signaling pathway may be a promising strategy for treating lung cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sadaf Dorandish, Sarah Atali, Ravel Ray, Hind Al Khashali, Kai-Ling Coleman, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Summary: The study found that the level of proBDNF in the media of A549 cells was higher than in H1299 cells, and these levels were likely regulated by PI3K, AKT, and NF kappa B. MMP9 plays a key role in regulating the cytotoxic effects induced by proBDNF in lung cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sk. Kayum Alam, Li Wang, Zhu Zhu, Luke H. Hoeppner
Summary: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and is often diagnosed at advanced stages with therapy-refractory disease progression. Understanding the molecular mechanisms of NSCLC progression is crucial for developing new therapies. Overexpression of I kappa B kinase alpha (IKK alpha) in NSCLC is associated with poor patient survival. Our study reveals that IKK alpha phosphorylates DARPP-32, inhibiting protein phosphatase 1 (PP1) and activating ERK signaling, promoting lung oncogenesis. Inhibition of IKK alpha reduces anchorage-independent growth in NSCLC cells and inhibits lung tumor growth in mice. These findings highlight the importance of IKK alpha in driving NSCLC growth through DARPP-32-mediated ERK activation.
NPJ PRECISION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Guoyu Wang, Xue Liu, Huaman Liu, Xinyue Zhang, Yumeng Shao, Xinhua Jia
Summary: We constructed a multigene signature consisting of eight genes for predicting the prognosis of lung adenocarcinoma (LUAD) using mRNA expression profiles and clinical data. The signature showed good predictive effect in differentiating high-risk and low-risk patients, and the differential genes in risk subgroups were associated with tumor immunity and drug sensitivity. We identified an lncRNA/miRNA/mRNA regulatory axis with important roles in LUAD.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Summary: This study found that notopterol can inhibit the IL-17-induced proliferation and invasion of A549 lung adenocarcinoma cells by suppressing the activation of the MAPK, Akt, STAT3, AP-1, and NF-kappa B signaling pathways, as well as modulating EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Longhua Feng, Pengjiang Cheng, Zhengyun Feng, Xiaoyu Zhang
Summary: The overexpression of TMED2 in LUAD is negatively correlated with malignant survival and apoptosis. Knockdown of TMED2 inhibits LUAD development and increases the levels of inflammatory factors. In addition, TMED2 is associated with TME-associated immune cells, their target markers, and some mechanisms and pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
S. M. Fazeela Mahaboob Begum, S. Hemalatha
Summary: This study evaluated the effects of compounds from Gelidiella acerosa on inflammation and antioxidant enzymes in lung cancer. The results showed that the extract has anti-inflammatory properties and enhances the efficiency of antioxidant enzymes while decreasing NF kappa B expression. The phyto-constituents of G. acerosa may have the potential to regulate the inflammatory response, providing a potential avenue for cancer treatment.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Sijia Ren, Jing Wang, Anyi Xu, Jiaqian Bao, William C. Cho, Jinrong Zhu, Jianfei Shen
Summary: This study found that ITGA6 overexpression was correlated with microlymphatic vessel density in LUAD specimens. Through experiments in vitro and in vivo, it was confirmed that ITGA6 upregulation significantly enhanced lymphangiogenesis and lymphatic metastasis. Mechanistically, ITGA6 sustained NF-KB activity by binding and promoting K63 polyubiquitination of TRAF2. CNV analysis revealed ITGA6 amplification in 27.5% of LUAD tissue samples.
Article
Endocrinology & Metabolism
Ming Wu, Dewei Kong, Yan Zhang
Summary: Bone metastasis is a major complication in lung adenocarcinoma (ADC) patients, and identifying biomarkers for this disease is crucial. This study found that SPON2 plays a key role in promoting bone metastasis by activating the NF-kappa B pathway in ADC. These findings suggest that SPON2 could be a potential therapeutic target for future drug development.
Article
Biochemistry & Molecular Biology
Qingli Bie, Hui Song, Xinke Chen, Xiao Yang, Shuo Shi, Lihua Zhang, Rou Zhao, Li Wei, Baogui Zhang, Huabao Xiong, Bin Zhang
Summary: The IL-17B/IL-17RB signaling cascade promotes self-renewal and tumorigenesis of CSCs by inducing Beclin-1 ubiquitination. IL-17RB expression is upregulated in gastric cancer (GC) tissues, correlating with cancer cell differentiation. The study suggests IL-17B as a potential therapeutic target for cancer treatment.
Article
Respiratory System
Lanlan Lin, Xiaohui Chen, Guofu Lin, Luyang Chen, Yuan Xu, Yiming Zeng
Summary: This study found that FUT3 is significantly upregulated in LUAD tissues, and high expression of FUT3 may predict poor prognosis in LUAD patients. Knockdown of FUT3 can significantly inhibit tumor proliferation, migration, and glucose metabolism alterations in LUAD cells. Furthermore, FUT3 upregulation is positively correlated with the NF-kappa B signaling pathway, and downregulation of FUT3 leads to inhibition of oncogenesis and glucose metabolism through inactivation of the NF-kappa B pathway.
BMC PULMONARY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Domling, Eman A. Mazyed, Farid A. Badria, Fardous F. El-Senduny
Summary: This study investigated the anticancer activity of the compound SP1 and its nanoformulation against breast adenocarcinoma. The results showed that SP1 exhibited strong inhibitory effects on multiple cancer cell lines and induced apoptosis. The use of a nanoformulation improved the selectivity of the compound against cancer cells. In vivo studies on mice confirmed the ability of SP1 to halt the proliferation of breast cancer cells and suppress metastasis.
BIOORGANIC CHEMISTRY
(2022)
Article
Dermatology
Seok-Jin Lee, Ki Baek Lee, Ah-Young Hong, Young Hoon Son, Dong Hun Lee, Eui Man Jeong, In-Gyu Kim
Summary: Matrix metalloproteinases play a crucial role in skin aging, with transglutaminase 2 identified as a key mediator linking UV irradiation to the upregulation of MMPs.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke
Article
Respiratory System
Jinlun Feng, Baomo Liu, Junwen Xu, Qinqin Wang, Lixia Huang, Weijun Ou, Jincui Gu, Jian Wu, Shaoli Li, Chao Zhuo, Yanbin Zhou
JOURNAL OF THORACIC DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Shuaiguang Li, Lianghua Shen, Luyuan Huang, Sijia Leia, Xingdong Cai, Mason Breitzig, Bin Zhan, Annan Yang, Wenzuo Ji, Meiyan Huang, Qing Zheng, Hanxiao Sun, Feng Wang
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Article
Oncology
Peng Song, Xiaoxia Cui, Li Bai, Xiangdong Zhou, Xiaoli Zhu, Jian Zhang, Faguang Jin, Jianping Zhao, Chengzhi Zhou, Yanbin Zhou, Xiaoju Zhang, Kai Wang, Qi Wang, Yao Yu, Xiaoyu Zhang, Chunxue Bai, Li Zhang
Article
Oncology
Xiaoxian Cui, Shaoli Li, Jincui Gu, Ziying Lin, Bipeng Lai, Lixia Huang, Jinlun Feng, Baomo Liu, Yanbin Zhou
Article
Medicine, Research & Experimental
Jia Hou, Shan-Shan Xiong, Zhao-Qi Huang, Xing-Dong Cai
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Virology
Xia-Qing Li, Han Liu, Yu Meng, Hai-Yan Yin, Wen-Yong Gao, Xiao Yang, Dian-Shuang Xu, Xing-Dong Cai, Yin Guan, Lilach O. Lerman, Zhi-Yong Peng, Hou-Rong Zhou
Summary: Acute kidney injury (AKI) is common in COVID-19 patients and is more prevalent in severe cases. Factors such as cytokine storm, ARDS, and kidney injury at admission play a significant role in the development of AKI. Long-term mechanical ventilation, cytokine storms, and secondary bacterial infections contribute to AKI-related mortality in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Respiratory System
Li Che, Chao Yu, Guangshu Chen, Jiaxin Lin, Zhefan Xie, Tingting Xia, Wenzhi Luo, Xingdong Cai, Shengming Liu
Summary: The research found that RELM beta can promote the expression of inflammatory cytokines IL-8 and IL-1 beta in airway epithelial cells of COPD patients, and this effect is mediated by the p38 MAPK signaling pathway. Therefore, RELM beta may be a potential target for the treatment of COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Guangshu Chen, Li Che, Xingdong Cai, Ping Zhu, Jianmin Ran
Summary: The study aimed to identify common genes, biological pathways, and treatment targets for primary Sjogren's syndrome patients with fatigue features. 27 DEGs related to fatigue features were identified, with chlorophyllin potentially alleviating fatigue symptoms in pSS patients. This study sheds light on specific gene regulations and potential treatment options for pSS patients with fatigue.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Oncology
Weijian Lin, Xing-Dong Cai
Summary: CEVs, derived from cancer cells, are a novel type of therapeutic agent in cancer treatment with anti-tumor potential. Current strategies classify CEVs into four different types, serving as carriers for anti-tumor drugs to target tumor areas and as immune-active agents.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li Che, Guangshu Chen, Xingdong Cai, Zhefan Xie, Tingting Xia, Wei Zhang, Shengming Liu
Summary: COVID-19 remains prevalent worldwide and poses a serious threat to human health, especially for COPD patients. This study aims to identify potential therapeutic targets by analyzing common differentially expressed genes (DEGs) between the two diseases and discovering drugs that may be effective for both conditions.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Xing-Dong Cai, Ying Yang, Jinzhong Li, Xiaoying Liao, Shijie Qiu, Jingjing Xu, Miao Zhang, Yuanshun Huang, Zhi-Hong Huang, Hong-Ming Ma
Article
Oncology
Ziying Lin, Jincui Gu, Xiaoxian Cui, Lixia Huang, Shaoli Li, Jinlun Feng, Baomo Liu, Yanbin Zhou
Article
Biotechnology & Applied Microbiology
Li Che, Guangshu Chen, Xingdong Cai, Zhefan Xie, Tingting Xia, Wei Zhang, Shengming Liu
Summary: The article analyzed the transcriptomic gene expression of COVID-19 and COPD, identified potential common DEGs and therapeutic targets, proposed some potential therapeutic agents to help manage the treatment of both diseases.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Li Che, Guangshu Chen, Xingdong Cai, Zhefan Xie, Tingting Xia, Wei Zhang, Shengming Liu
Summary: COVID-19 remains prevalent in certain regions, posing a severe threat to human health, especially for COPD patients. By analyzing common differentially expressed genes in both diseases, identifying potential therapeutic targets, and discovering potential therapeutic agents.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.