Review
Medicine, Research & Experimental
Javier Munoz-Garcia, Denis Cochonneau, Stephane Teletchea, Emilie Moranton, Didier Lanoe, Regis Brion, Frederic Lezot, Marie-Francoise Heymann, Dominique Heymann
Summary: Macrophages are specialized cells that control tissue homeostasis, relying on specific growth factors and receptors for differentiation and polarization. Macrophage-colony stimulating factor (CSF-1) and interleukin-34 (IL-34) are twin cytokines that share a common receptor, activating similar signaling pathways with some differential activation leading to specific activities.
Review
Immunology
Ryo Otsuka, Haruka Wada, Ken-ichiro Seino
Summary: IL-34 is a cytokine that shares a receptor with CSF-1 and shows similar downstream signaling pathways. Its expression is upregulated in cancer, contributing to therapy resistance and disease progression, while being downregulated in some brain and dermal disorders.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emese Toth, Ferenc Erdodi, Andrea Kiss
Summary: The differentiation of monocytes into macrophages involves the activation of multiple signaling pathways, potentially influenced by protein kinases and phosphatases. Myosin phosphatase (MP) plays a role in controlling macrophage differentiation, with its activity modulated during this process. Targeting MP activation/inhibition could be a potential pharmacological intervention to regulate disease states associated with excessive macrophage differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Qianyue Zhang, Qiaoling Song, Shan Liu, Yuting Xu, Danling Gao, Peizhe Lu, Yuantao Liu, Guanghui Zhao, Lihong Wu, Chenyang Zhao, Jinbo Yang
Summary: This study investigated the metabolic differences between GM-BMDMs and M-BMDMs and their consistency with protein levels through transcriptome and metabolome analysis. The core metabolic pathways of macrophages were found to be closely associated with canonical macrophage functions such as inflammatory response and phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Xiaoling Xie, Wuju Zhang, Min Xiao, Tiantian Wei, Yingqi Qiu, Jingyang Qiu, Hao Wang, Zeyou Qiu, Sheng Zhang, Yating Pan, Linlin Mao, Yuhua Li, Bin Guo, Wanwen Yang, Yuxing Hu, Shujie Hu, Yan Gong, Jun Yang, Guozhi Xiao, Yue Zhang, Xiaochun Bai
Summary: The bone marrow microenvironment plays a crucial role in the development of acute myeloid leukemia (AML). This study found that mutated osteoclasts suppressed AML development by releasing high levels of interleukin-34 (IL-34), which promoted AML cell differentiation. This was achieved through the binding of IL-34 to triggering receptor expressed on myeloid cells 2 (TREM2), leading to the inhibition of AML progression.
Article
Biology
Nigel A. Morrison, Mark R. Forwood
Summary: In this study, the effects of different cytokines on the expression of chemokines in human CD14(+) cells in culture were investigated. It was found that M-CSF treatment promoted MCP1 expression, while GM-CSF suppressed MCP1 expression. Furthermore, addition of MCP1 significantly increased osteoclast formation and overcame the suppression caused by GM-CSF.
Review
Cell Biology
Antoine Freuchet, Apolline Salama, Severine Remy, Carole Guillonneau, Ignacio Anegon
Summary: IL-34 and CSF-1 play crucial roles in the survival and differentiation of monocytes/macrophages, with differences in receptor binding and signaling despite sharing similar structures. IL-34 has additional receptors and potential actions beyond monocyte/macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Jule, Jean-Claude Martinou, Gerard Pierron, Julie Riviere, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary
Summary: Circulating monocytes are recruited to damaged tissues to generate macrophages that modulate disease progression. Activation of caspase-3 and caspase-7, located near mitochondria, is involved in the generation of monocyte-derived macrophages stimulated by Colony-stimulating factor-1 (CSF-1). A non-conventional pathway that involves caspases and activates NOX2 is responsible for CSF1-driven monocyte differentiation, and targeting this pathway may have therapeutic implications for modulating macrophage polarization in damaged tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sneha M. Pinto, Hera Kim, Yashwanth Subbannayya, Miriam S. Giambelluca, Korbinian Bosl, Liv Ryan, Animesh Sharma, Richard K. Kandasamy
Summary: The study demonstrated the impact of variations in PMA concentration and post-stimulation rest duration on the protein expression and cellular signaling processes in macrophage-like cells, leading to altered inflammatory responses and cytokine expression levels. This provides valuable insights into the dynamics of protein expression with common in vitro macrophage models, significantly expanding knowledge in immune and inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yaxiong Fang, Kongyang Ma, Yi-Min Huang, Yuanye Dang, Zhaoyu Liu, Yiming Xu, Xi-Long Zheng, Xiangdong Yang, Yongliang Huo, Xiaoyan Dai
Summary: Upon migrating into the tissues, HSC-derived monocytes differentiate into macrophages, which play a crucial role in regulating immune responses. However, the mechanisms underlying monocyte-to-macrophage differentiation are not well understood. This study reveals that FLRT2, an axon guidance molecule, is essential for monocyte-to-macrophage maturation. FLRT2 interacts with UNC5B and activates Akt/mTOR signaling to promote monocyte differentiation. Targeting the FLRT2/UNC5B-Akt/mTOR axis may provide therapeutic strategies for diseases associated with abnormal monocyte/macrophage differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alicia Villatoro, Vincent Cuminetti, Aurora Bernal, Carlos Torroja, Itziar Cossio, Alberto Benguria, Marc Ferre, Joanna Konieczny, Enrique Vazquez, Andrea Rubio, Peter Utnes, Xiaona You, Christopher G. Fenton, Ruth H. Paulssen, Jing Zhang, Fatima Sanchez-Cabo, Ana Dopazo, Anders Vik, Endre Anderssen, Andres Hidalgo, Lorena Arranz
Summary: The balance between IL-1rn and IL-1 beta levels regulates HSC differentiation, and repression of IL-1 beta signaling by IL-1rn protects against pre-leukemic myelopoiesis.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Paul Chaintreuil, Emeline Kerreneur, Maxence Bourgoin, Coline Savy, Cecile Favreau, Guillaume Robert, Arnaud Jacquel, Patrick Auberger
Summary: Macrophages can adopt various phenotypes and play important roles in immune response, inflammation, and tissue repair. In human tissues, there are three main subpopulations of macrophages: naive macrophages, pro-inflammatory macrophages, and anti-inflammatory macrophages. Naive macrophages display phagocytic functions and can polarize into pro or anti-inflammatory macrophages. Pro-inflammatory macrophages are involved in the inflammatory response, while anti-inflammatory macrophages aid in the resolution of inflammation and tissue repair. Understanding the molecular mechanisms of macrophage generation, activation, and polarization is crucial for developing new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yue Cui, Saray Gutierrez, Sheller Ariai, Lisa Oberg, Kristofer Thorn, Ulf Gehrmann, Suzanne M. Cloonan, Thomas Naessens, Henric Olsson
Summary: Iron is essential for oxygen delivery and energy metabolism. High levels of non-heme iron can interfere with macrophage differentiation and function, leading to mitochondrial oxidative stress and impaired ATP generation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Paul Chaintreuil, Lucie Laplane, Florian Esnault, Victoria Ghesquier, Coline Savy, Nathan Furstoss, Marie-Laure Arcangeli, Thomas Cluzeau, Guillaume Robert, Nathalie Droin, Eric Solary, Patrick Auberger, Arnaud Jacquel
Summary: Macrophages are innate immune cells that play crucial roles in various physiological and pathological processes. Caspases, previously known for their involvement in programmed cell death, are found to have non-apoptotic functions in macrophage differentiation and inflammation. Emricasan, a pan-caspase inhibitor, has shown potential in reprogramming monocyte-derived macrophages and could be an alternative therapy for diseases driven by these macrophages.
Article
Oncology
Tomoaki Irie, Daiki Yoshii, Yoshihiro Komohara, Yukio Fujiwara, Masashi Kadohisa, Masaki Honda, Shinya Suzu, Toshiharu Matsuura, Kenichi Kohashi, Yoshinao Oda, Taizo Hibi
Summary: This study aimed to investigate the potential roles of macrophages in hepatoblastoma. The findings revealed significant differences in the number of macrophages among different histological subtypes. In vitro experiments showed that conditioned medium from hepatoblastoma cell lines induced increased CD163 expression in macrophages, and direct co-culture with macrophages induced tumor cell proliferation. Additionally, overexpression of IL-34 in embryonal components promoted tumor cell proliferation and chemoresistance.
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.