Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Microbiology
Li-Fang Chou, Ting-Wen Chen, Huang-Yu Yang, Ya-Chung Tian, Ming-Yang Chang, Cheng-Chieh Hung, Chih-Ho Lai, Shen-Hsing Hsu, Chung-Ying Tsai, Yi-Ching Ko, Jang-Hau Lian, Chih-Wei Yang
Summary: Macrophages play a crucial role in the immune response to Leptospira spp. infection. This study investigated the transcriptome-wide alterations in macrophages infected with pathogenic and nonpathogenic Leptospira spp. The results revealed differential pathways and biological processes between pathogenic and nonpathogenic infections, providing potential therapeutic targets for the treatment of leptospirosis.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Benquan Liu, Jun Jiang, Hua Liang, Ping Xiao, Xiaohong Lai, Jiayi Nie, Wenqiang Yu, Ying Gao, Shihong Wen
Summary: This study revealed the important role of natural killer T (NKT) cells in regulating renal fibrosis. Activation of NKT cells leads to more severe fibrosis, while CD1d deficiency protects mice from renal fibrosis. Targeting NKT cell/IL-4 signaling may be an effective treatment for renal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathan Dubois, Achille Ruer, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Summary: Mesenchymal stromal cells (MSC) play a critical role in aging and inflammaging, and studying them is important for understanding the mechanisms of diseases in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chao Hong, Hongyun Lu, Rong Jin, Xiaohong Huang, Ming Chen, Xiaoqiu Dai, Fangyuan Gong, Hongliang Dong, Hongmin Wang, Xiao-Ming Gao
Summary: The lack of IL-13-secreting ILC2s in the lungs may be responsible for poor AM reconstitution post haplo-BMT. Supplementing with factors like IL-13 can enhance donor monocyte-derived AM reconstitution and innate immunity against pulmonary bacterial infection in recipient animals. These findings offer a potential clinical strategy for preventing early pulmonary bacterial infection in BMT recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dominika Borowska, Samantha Sives, Lonneke Vervelde, Kate M. Sutton
Summary: This study analyzes chicken macrophages and dendritic cells, revealing differences in phenotype, function, and transcription. The BM cultures with CSF2 and IL-4 tend to represent cells of the macrophage lineage rather than conventional dendritic cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Kazuki Inoue, Yongli Qin, Yuhan Xia, Jie Han, Ruoxi Yuan, Jun Sun, Ren Xu, Jean X. Jiang, Matthew B. Greenblatt, Baohong Zhao
Summary: Adipoq-lineage progenitors in bone marrow are the main cellular source of M-CSF, producing much higher levels than osteoblast lineage cells. Deficiency of M-CSF in these progenitors significantly reduces the generation of bone marrow macrophages and osteoclasts, leading to severe osteopetrosis.
Article
Cell & Tissue Engineering
Zhenyu Li, Qingxian Li, Kai Tong, Jiayong Zhu, Hui Wang, Biao Chen, Liaobin Chen
Summary: This study investigated the effect of rat bone marrow stromal cell-derived exosomes (BMSC-Exos) on tendon-bone healing after anterior cruciate ligament reconstruction (ACLR). The results showed that BMSC-Exos promoted the polarization of M1 macrophages to M2 macrophages via miR-23a-3p. This reduced the early inflammatory reaction at the tendon-bone interface and promoted early healing after ACLR.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Xuzheng Liu, Wanli Chen, Bo Shao, Xinchi Zhang, Yinggang Wang, Siqian Zhang, Wei Wu
Summary: The study showed that by rational designing hierarchically porous membranes with 3D microstructure, it can facilitate early and durable influx of M2 macrophages, promoting recruitment of BMSCs and osteogenesis. Additionally, the 4D morphing of the membrane can fully regenerate calvarial bone and arcshape bone.
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Weiyang Li, Jieshi Xie, Le Yang, Yuanru Yang, Lin Yang, Liying Li
Summary: The study found that 15d-PGJ2 can reduce MIF expression in damaged hepatocytes by activating PPARγ, thereby inhibiting macrophage infiltration and inflammatory response, ultimately alleviating acute liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Anuj Sehgal, Dylan Carter-Cusack, Sahar Keshvari, Omkar Patkar, Stephen Huang, Kim M. Summers, David A. Hume, Katharine M. Irvine
Summary: Homozygous null mutation of the Csf1r gene (Csf1rko) in rats leads to the loss of most tissue macrophage populations and pleiotropic impacts on postnatal growth and organ maturation, leading to early mortality. The phenotype can be reversed by intraperitoneal transfer of WT BM cells (BMT) at weaning. Rat BM contains progenitor cells that are able to restore, replace, and maintain all tissue macrophage populations in a Csf1rko rat directly without contributing to the BM progenitor or blood monocyte populations.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tiemei Li, Xiaotao Su, Pinglan Lu, Xinmei Kang, Mengyan Hu, Chunyi Li, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Yuxin Liu, Xiaohui Deng, Wei Cai, Lei Wei, Zhengqi Lu
Summary: Pneumonia is a common cause of death in patients with acute ischemic stroke (AIS), and antibiotics are not effective in improving the prognosis due to the negative impact on the immune system. However, a recent study found that bone marrow mesenchymal stem cells (BM-MSC) can reduce bacterial load in the lungs of stroke mice, and this is achieved by modulating the activities of pulmonary macrophages. The study also identified that BM-MSC releases migrasomes, which contain the antibacterial peptide dermcidin (DCD) and enhance the phagocytosis of macrophages.
Article
Engineering, Biomedical
Wenbo Chen, Yaying Sun, Xueping Gu, Jiangyu Cai, Xingwang Liu, Xingyu Zhang, Jiwu Chen, Yuefeng Hao, Shiyi Chen
Summary: Stem cell-related therapies play a significant role in rotator cuff repair, with their secretome having a significant impact on tendon-bone healing. Research indicates that by modulating macrophage polarization, the conditioned medium of stem cells can promote faster tendon-bone healing.
Article
Immunology
Maria Luisa Barcena, Maximilian H. Niehues, Celine Christiansen, Misael Estepa, Natalie Haritonow, Amir H. Sadighi, Ursula Mueller-Werdan, Yury Ladilov, Vera Regitz-Zagrosek
Summary: The study found that in an inflammatory environment, male mice exhibited stronger polarization and activation of macrophages and cardiac fibroblasts compared to females, suggesting a significant role of sex in cardiac pathologies.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Ophthalmology
Jordan L. Mitchell, Laura Ganis, Benjamin T. Blacklock, Harry Petrushkin, Jayne C. Hope, Danielle A. Gunn-Moore
Summary: Tuberculosis is an ancient infectious disease that causes millions of deaths each year in humans, as well as significant morbidity and mortality in animals. Ocular tuberculosis is a recognized condition in humans, but its occurrence in animals, such as cattle and domestic cats, requires further investigation in order to improve treatment outcomes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Veterinary Sciences
Zofia M. Lisowski, Lucas Lefevre, Tim S. Mair, Emily L. Clark, Neil P. H. Hudson, David A. Hume, R. Scott Pirie
Summary: Studies have shown an upregulation of inflammatory genes in the intestine of horses undergoing colic surgery. Horses that developed post-operative reflux had significantly greater relative gene expression of TNF in the mucosa compared with horses that did not develop reflux.
EQUINE VETERINARY JOURNAL
(2022)
Article
Cell Biology
Sahar Keshvari, Berit Genz, Ngari Teakle, Melanie Caruso, Michelle F. Cestari, Omkar L. Patkar, Brian W. C. Tse, Kamil A. Sokolowski, Hilmar Ebersbach, Julia Jascur, Kelli P. A. MacDonald, Gregory Miller, Grant A. Ramm, Allison R. Pettit, Andrew D. Clouston, Elizabeth E. Powell, David A. Hume, Katharine M. Irvine
Summary: Resident and recruited macrophages play a crucial role in the development and proliferation of the liver. Previously, the use of a macrophage colony stimulating factor (CSF1)-Fc fusion protein has been shown to promote hepatocyte proliferation and repair in acute hepatic injury in mice. In this study, the impact of CSF1-Fc on the resolution of advanced fibrosis and liver regeneration was investigated using a toxin-induced model of chronic liver injury and fibrosis in mice. The findings suggest that CSF1-dependent macrophages contribute to both the initiation and resolution of fibrotic injury, and that CSF1-Fc has therapeutic potential in the treatment of human liver disease.
DISEASE MODELS & MECHANISMS
(2022)
Article
Immunology
Zhiguang Wu, Tuanjun Hu, Cosmin Chintoan-Uta, Joni Macdonald, Mark P. Stevens, Helen Sang, David A. Hume, Pete Kaiser, Adam Balic
Summary: Conventional dendritic cells (cDC) are crucial in chicken immunity, and this study has developed novel reagents for their identification and characterization. These original reagents facilitate further research on the important roles of chicken cDCs in immunity and diseases.
Article
Veterinary Sciences
Marta Garcia-Arce, Adam G. Gow, Ian Handel, Waiyin Ngoi, Emily Thomas
Summary: The admission RDW in critically ill dogs was not associated with in-hospital mortality or length of hospitalization, and there was no significant correlation between RDW and leukocyte count.
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2022)
Article
Developmental Biology
Jennifer Stables, Emma K. Green, Anuj Sehgal, Omkar L. Patkar, Sahar Keshvari, Isis Taylor, Maisie E. Ashcroft, Kathleen Grabert, Evi Wollscheid-Lengeling, Stefan Szymkowiak, Barry W. McColl, Antony Adamson, Neil E. Humphreys, Werner Mueller, Hana Starobova, Irina Vetter, Sepideh Kiani Shabestari, Matthew M. Blurton-Jones, Kim M. Summers, Katharine M. Irvine, Clare Pridans, David A. Hume
Summary: Amino acid substitutions in the kinase domain of the human CSF1R gene are associated with ALSP. A disease-associated mutation was created in the mouse Csf1r locus to model the human disease. This mutation affected the production of tissue macrophages and microglial cells in the mouse brain.
Article
Veterinary Sciences
K. E. Rolph, S. M. Cavanaugh, H. E. Wilson
Summary: This case report describes the first documented case of suspected glycogen storage disease type 1a in an adult dog.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Veterinary Sciences
Amin Azadian, Danielle A. Gunn-Moore
Summary: This study found that age and FIV infection have significant impacts on cognitive abilities in cats. Younger cats have better visuospatial working memory and problem-solving abilities, with FIV infection having minimal effects. However, older FIV-positive cats exhibit worse visuospatial working memory but no differences in problem-solving abilities.
Article
Microbiology
Petra Cerna, Ashley Ayoob, Caroline Baylor, Erin Champagne, Sandra Hazanow, Robert E. Heidel, Kimberly Wirth, Alfred M. Legendre, Danielle A. Gunn-Moore
Summary: Feline infectious peritonitis remains a challenge in feline medicine. Treatment with Polyprenyl Immunostimulant shows promise in enhancing the immune response. However, persistently low hematocrit and albumin:globulin ratio indicate a negative prognosis. Further studies are needed to establish optimal treatment protocols.
Review
Veterinary Sciences
Kerry E. Rolph, Sarah M. Cavanaugh
Summary: Pulmonary hypertension (PH) has often been overlooked in feline medicine, but increased awareness of potential causes in humans has led to a greater understanding of the disease process. It is important to recognize the different forms of PH encountered in different species, and propose a classification system for feline patients. As new medications for PH are developed, understanding the forms of PH in cats and the underlying causes is crucial. This review highlights the numerous conditions and etiologies associated with PH in cats, and improving our understanding of this condition will allow for investigation of potential new diagnostics and therapies.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Veterinary Sciences
Ailbhe King, Kerry E. Rolph, Loveness Dzikiti, Sarah M. Cavanaugh
Summary: This study aimed to assess and compare the quality of smartphone ECG tracings to standard ECG tracings and evaluate the agreement of ECG parameters between the two. The results showed that standard ECG had superior quality compared to smartphone ECG, but there was good agreement in heart rate, P wave amplitude, QRS duration, QT interval, T wave duration, and T wave amplitude between the two devices.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2023)
Article
Veterinary Sciences
Kerry E. Rolph, John Ryan, Donald Yool, Tiziana Liuti
Summary: Megaesophagus in cats can be caused by paraesophageal hernia. In this case, correcting the paraesophageal hernia resulted in complete resolution of esophageal dilation and all associated clinical signs.
JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS
(2023)
Article
Veterinary Sciences
Kerry E. Rolph, Beatriz Vidana, Elinor Field
Summary: We report the first case of giant splenic myelolipoma in a hyperthyroid cat. This condition is rarely seen in domestic cats, with only five documented cases in the literature, none of which have described a giant myelolipoma. Giant myelolipomas are also rare in the human literature and are most commonly adrenal in origin. The pathogenesis of these masses is still unclear, but it has been suggested that endocrine stimulation may play a role.
JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS
(2022)
Review
Veterinary Sciences
Kerry E. Rolph, Ryan P. Cavanaugh
Summary: This review summarizes the current literature on neoplasia associated with infectious diseases in domestic cats, focusing on viruses, bacteria, and parasites. Viruses such as feline leukemia virus, feline immunodeficiency virus, and papillomaviruses have received the most attention, while bacteria such as Helicobacter species and parasites like Platynosomum fastosum and Opisthorchis viverrini have also been studied. The findings suggest that infectious diseases can directly or indirectly contribute to the development and progression of tumors.
VETERINARY SCIENCES
(2022)
Article
Genetics & Heredity
Kim M. Summers, Stephen J. Bush, Chunlei Wu, David A. Hume
Summary: The researchers generated a comprehensive rat transcriptomic atlas by curating and downloading a large number of rat RNA-seq datasets. Through gene co-expression network analysis, they identified tissue and cell type specific transcript clusters and found transcription factors associated with lineage determination. The atlas provides a valuable resource for analyzing the transcriptomes of unexplored cell types and tissues.
NAR GENOMICS AND BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
