期刊
CYTOKINE
卷 61, 期 1, 页码 205-209出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2012.09.019
关键词
Cytokines; Spaceflight; Herpes virus reactivation; Stress; Astronauts
资金
- NASA [111-30-10-03, 111-30-10-06]
Success of long duration space missions will depend upon robust immunity. Decreased immunity has been observed in astronauts during short duration missions, as evident by the reactivation of latent herpes viruses. Seventeen astronauts were studied for reactivation and shedding of latent herpes viruses before, during, and after 9-14 days of 8 spaceflights. Blood, urine, and saliva samples were collected 10 days before the flight (L-10), during the flight (saliva only), 2-3 h after landing (R + 0), 3 days after landing (R + 3), and 120 days after landing (R + 120). Values at R + 120 were used as baseline levels. No shedding of viruses occurred before flight, but 9 of the 17 (designated virus shedders) shed at least one or more viruses during and after flight. The remaining 8 astronauts did not shed any of the 3 target viruses (non-virus shedders). Virus-shedders showed elevations in 10 plasma cytokines (IL-1 alpha, IL-6, IL-8, IFN gamma, IL-4, IL-10, IL-12, IL-13, eotaxin, and IP-10) at R + 0 over baseline values. Only IL-4 and IP-10 were elevated in plasma of non-virus shedders. In virus shedders, plasma IL-4 (a Th2 cytokine) was elevated 21-fold at R + 0, whereas IFN gamma (a Th1 cytokine) was elevated only 2-fold indicating a Th2 shift. The inflammatory cytokine IL-6 was elevated 33-fold at R + 0. In non-shedding astronauts at R + 0, only IL-4 and IP-10 levels were elevated over baseline values. Elevated cytokines began returning to normal by R + 3, and by R + 120 all except IL-4 had returned to baseline values. These data show an association between elevated plasma cytokines and increased viral reactivation in astronauts. (C) 2012 Published by Elsevier Ltd.
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