Article
Immunology
Yu-Wei Chang, Ling-Chien Hung, Yu-Cheng Chen, Wen-Hung Wang, Chun-Yu Lin, Hsin-Han Tzeng, Jau-Ling Suen, Yen-Hsu Chen
Summary: Insulin may reduce inflammation by regulating the NLRP3 inflammasome, as demonstrated in in vivo models, providing evidence for its potential immunomodulatory role in anti-inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tiia Snaekae, Amel Bekkar, Chantal Desponds, Florence Prevel, Stephanie Claudinot, Nathalie Isorce, Filipa Teixeira, Coline Grasset, Ioannis Xenarios, Isabel C. Lopez-Mejia, Lluis Fajas, Nicolas Fasel
Summary: Mitochondria regulate steroid hormone synthesis and sex hormones regulate mitochondrial function. NLRX1 attenuates inflammation and modulates metabolic functions. NLRX1 attenuates inflammation in female mice but not in male mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yi Ren, Shaoyuan Cui, Quan Hong, Wanjun Shen, Qinggang Li, Lingling Wu, Bo Fu, Xu Wang, Qian Ma, Jiaona Liu, Xueyuan Bai, Xiangmei Chen
Summary: Activation of NOD-like receptors (NLRs) can lead to renal metabolic injury. In a diabetic minipig model, the expression of NLRs was significantly upregulated, along with activation of the NF-κB signaling pathway and increased levels of inflammatory cytokines.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Fan Hui, Siqi Guo, Jinzhao Liu, Meiao Li, Ming Geng, Yimeng Xia, Xin Liu, Qingwei Li, Jun Li, Ting Zhu
Summary: This study identified and characterized nine NLR genes in the lamprey genome and investigated their evolutionary patterns. The results suggest that Lr-NODa and Lr-NODb likely share a common ancestor with NOD1 and NOD2 in jawed vertebrates, and that Lr-NODb may have been generated by tandem duplication in lampreys. Phylogenetic analysis of the NLRC subfamily indicates that Lr-NLRC3a exhibits ancestral traits and may have evolved from the common ancestor of another vertebrate NLRC subfamily. Analysis of the NLRC subfamily evolution reveals the importance of exon shuffling, domain recombination, and chromosome rearrangement. Additionally, the expression analysis shows that NLR genes in lampreys are highly expressed in immune tissues and respond significantly to pathogen infection.
MOLECULAR IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yanjing Li, Shaojingya Gao, Sirong Shi, Dexuan Xiao, Shuanglin Peng, Yang Gao, Ying Zhu, Yunfeng Lin
Summary: The tFNA-based delivery of resveratrol (RSB) can improve insulin sensitivity and alleviate inflammation in high-fat diet-fed mice by modulating immune responses and macrophage phenotype. The synthesized nanoparticles, tFNAs-RSV, show potential as a therapeutic approach for treating insulin resistance and obesity-related metabolic diseases by targeting immune cell activation and inflammation.
NANO-MICRO LETTERS
(2021)
Article
Agriculture, Dairy & Animal Science
H. Dai, D. N. Coleman, M. G. Lopes, L. Hu, I Martinez-Cortes, C. Parys, X. Shen, J. J. Loor
Summary: This study aimed to assess the impact of increased Met and Arg supply on mRNA abundance of genes associated with innate immune response, antioxidant function, and AA metabolism during iE-DAP challenge in bovine mammary epithelial cells (BMEC). The results showed that the increased supply of both Met and Arg in the culture medium was more effective in modulating the innate immune response and antioxidant capacity of BMEC during in vitro iE-DAP stimulation.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Nutrition & Dietetics
Raquel Selma-Gracia, Polona Megusar, Claudia Monika Haros, Jose Moises Laparra Llopis
Summary: The study compared the effects of immunonutritional bioactives from quinoa and chia on high fat diet-induced insulin resistance. Results showed that these products improved hepatic lipid accumulation, glucose homeostasis, and normalized HOMA-IR. These positive effects were associated with positive variations in the peripheral myeloid cells population.
Article
Multidisciplinary Sciences
Sarah Bauer, Vanessa Aeissen, Alena M. Bubeck, Ioannis Kienes, Kornelia Ellwanger, Mona Scheurenbrand, Fjolla Rexhepi, Sheela Ramanathan, Philip Rosenstiel, W. Florian Fricke, Thomas A. Kufer
Summary: Nucleotide-binding and oligomerization domain containing 5 (NLRC5) is a transcriptional regulator of major histocompatibility (MHC) class I genes. Its role extends beyond MHC genes, as it is also involved in metabolic traits. In this study, we found that NLRC5 contributes to weight gain in mice fed a high-fat diet (HFD) by enhancing the expression of peroxisome proliferator-activated receptor (PPAR) gamma target genes. We also identified two novel interaction partners of NLRC5, Sin3A and negative elongation factor (NELF) B, which partly modulate NLRC5's transcriptional effect.
Article
Cell Biology
Christina F. Budden, Linden J. Gearing, Romina Kaiser, Lena Standke, Paul J. Hertzog, Eicke Latz
Summary: The text explains that activation of inflammasomes can lead to inflammation and immune pathology, but EVs released by inflammasome-activated cells also contain specific RNA, which can induce interferon beta in bystander cells to suppress NLRP3 inflammasome responses.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Cell Biology
Tatsuo Kawai, Michael Autieri, Rosario Scalia
Summary: Chronic low-grade inflammation of adipose tissue is linked to metabolic disease and organ complications, mainly caused by the secretion of inflammatory substances by adipocytes and infiltration of immune cells. Despite being low-grade, this inflammation negatively impacts remote organ function and is considered a causative factor of obesity-related complications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Antonio Citro, Francesco Campo, Erica Dugnani, Lorenzo Piemonti
Summary: Type 1 diabetes remains challenging to treat, with available methods unable to effectively delay the onset and progression of the disease. Recent research has revealed that diabetes is not solely mediated by T cells in autoimmune processes, as macrophages and neutrophils also play a role in beta cell destruction. Understanding the regulation of cytokines is essential in improving glucose metabolism and preventing autoimmune damage.Combining immunomodulatory strategies targeting both innate and adaptive immunity may be more effective in preventing or delaying islet damage and T1D onset.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Geriatrics & Gerontology
Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani, Abderrezak Bouchama
Summary: The COVID-19 pandemic has infected millions and caused over a million deaths, with age and underlying health conditions being major factors for severity and mortality. Obesity has emerged as a new risk factor for severe disease and death due to COVID-19.
Article
Biochemistry & Molecular Biology
Tiantian Fan, Yinchun Ji, Danqi Chen, Xia Peng, Jing Ai, Bing Xiong
Summary: In this study, a series of novel RIPK2 inhibitors were designed and synthesized, and compound 14 was identified as a potent inhibitor that can effectively reduce the secretion of MDP-induced TNF-alpha. Compound 14 showed good stability and has potential applications in further physiological and biochemical research.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Aditya Sharma, Sushmita Singh, Alok Mishra, Amit K. Rai, Ishbal Ahmad, Shadab Ahmad, Farah Gulzar, Jonathan D. Schertzer, Ashutosh Shrivastava, Akhilesh K. Tamrakar
Summary: The study reveals the crucial role of NOD1 signaling pathway in various metabolic tissues during the progression of diet-induced insulin resistance, highlighting the correlation between inflammation and insulin resistance.
Article
Immunology
Hyun Ji Ha, Ju Hyeong Kim, Gwan Hee Lee, Subin Kim, Hyun Ho Park
Summary: IRGB10, an interferon-inducible GTPase, plays a crucial role in host defense mechanisms by disrupting pathogenic membranes. However, the molecular mechanism behind IRGB10-mediated microbial membrane disruption is still unclear. In this study, we determined the structures of IRGB10 in nucleotide-free and GppNHp-bound forms and found that it exists as a monomer in both states. We also demonstrated that GTP hydrolysis is necessary for dimer formation and oligomerization of IRGB10. Based on these findings, we proposed a mechanistic model for the working mechanism of IRGB10 during pathogen membrane disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychology
Narayanaswamy Jagannathan, Ranjit Mohan Anjana, Thaharullah Shah Mehreen, Kanniyappan Yuvarani, Dhanasekar Sathishkumar, Subramani Poongothai, Viswanathan Mohan, Sathish Latha, Harish Ranjani
Summary: This study aimed to evaluate the reliability and validity of the ADOlescence Stress Scale (ADOSS) as a tool to assess stress levels in Indian adolescents aged 10-17 years. The results showed that ADOSS is a reliable and valid tool, with significant positive correlation between ADOSS scores and salivary cortisol levels.
INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Charlotte Steenblock, Nicole Toepfner, Felix Beuschlein, Nikolaos Perakakis, Ranjit Mohan Anjana, Viswanathan Mohan, Nitish R. Mahapatra, Stefan R. Bornstein
Summary: The SARS-CoV-2 virus can infect various tissues including endocrine organs, leading to organ damage or dysfunction. The main receptor ACE2 is expressed in cells of the endocrine system, and the virus has been found in post-mortem samples from COVID-19 patients. The exact mechanisms are not fully understood and further research is needed. Additionally, endocrine diseases may impact the severity of COVID-19, highlighting the importance of reducing their prevalence or improving treatment in the future.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Natarajan Lakshmi, Rajendra Pradeepa, Ranjit Mohan Anjana, Hari Rakesh, Radhakrishnan Subashini, Ulagamathesan Venkatesan, Mohan Deepa, Nora Vigasini, Moneeza Kalhan Siddiqui, Ewan R. Pearson, Colin N. A. Palmer, Viswanathan Mohan
Summary: This study aimed to assess the secular trends in the prevalence of diabetes and pre-diabetes from two cross-sectional studies done 11 years apart, in rural Tamil Nadu. The study found that the prevalence of diabetes among adults in rural south India has dramatically increased while that of prediabetes has decreased, over an 11-year period.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Public, Environmental & Occupational Health
Jannie Nielsen, Roopa Shivashankar, Solveig A. Cunningham, Dorairaj Prabhakaran, Nikhil Tandon, Viswanathan Mohan, Romaina Iqbal, K. M. Venkat Narayan, Mohammed K. Ali, Shivani Anil Patel
Summary: Little is known about couple concordance in chronic diseases in urban India and Pakistan. This study found a high concordance of chronic conditions among couples in these regions, especially in couples with higher socioeconomic status.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Nutrition & Dietetics
Viswanathan Mohan, Vasudevan Sudha, Shanmugam Shobana, Rajagopal Gayathri, Kamala Krishnaswamy
Summary: The prevalence of diabetes is increasing rapidly globally, especially in India, where the urbanization and globalization have led to changes in dietary patterns and lifestyle factors that contribute to the diabetes epidemic. The consumption of processed refined grain staples, inadequate nutrient intake, unhealthy fats, and sedentary lifestyles are the main drivers of diabetes in India. This review discusses the quality and quantity of Indian diets and proposes strategies to address the diabetes epidemic, with potential implications for other developing nations in the South East Asian region.
JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Aastha Aggarwal, Ranganathan Rama, Preet K. Dhillon, Mohan Deepa, Dimple Kondal, Naveen Kaushik, Dipika Bumb, Ravi Mehrotra, Betsy A. Kohler, Viswanathan Mohan, Theresa W. Gillespie, Alpa Patel, Swaminathan Rajaraman, Dorairaj Prabhakaran, Kevin C. Ward, Michael Goodman
Summary: To test a systematic alternative approach, a population-based cohort in Chennai, India was linked with a local population-based cancer registry, and the study found a high level of agreement between self-reported diagnoses and registry-based diagnoses. These findings provide important insights for future cancer surveillance and research in low-income and middle-income countries.
Article
Endocrinology & Metabolism
Ramasamy Aarthy, Kathryn Aston-Mourney, Anandakumar Amutha, Antonina Mikocka-Walus, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Saravanan Jebarani, Ulagamathesan Venkatesan, Sundaramoorthy Gopi, Venkatesan Radha, Viswanathan Mohan
Summary: This study investigates the prevalence, clinical features, and complications of MODY in a tertiary diabetes center in South India and compares them with T1D and T2D. The results show a high prevalence of retinopathy and nephropathy in MODY patients, highlighting the importance of early diagnosis and better diabetes control for individuals with MODY.
PRIMARY CARE DIABETES
(2023)
Editorial Material
Endocrinology & Metabolism
Michael Bergman, Martin Buysschaert, Antonio Ceriello, Akhtar Hussain, Viswanathan Mohan, Giorgio Sesti, Jaakko Tuomilehto
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Jothydev Kesavadev, Viswanathan Mohan
Summary: The increasing diabetes population has resulted in escalated costs and overburdened physicians. Patient-friendly technologies, such as telemedicine and mobile apps, can significantly reduce complications and improve healthcare outcomes. Remote monitoring and wearable devices also play a vital role in preventing long-term complications and improving patients' quality of life.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Review
Multidisciplinary Sciences
Bhavadharini Balaji, Uma Ram, Viswanathan Mohan
Summary: Gestational diabetes mellitus (GDM) refers to abnormal glucose tolerance detected for the first time during pregnancy. GDM is associated with obstetric and neonatal complications and increases the risk of future diabetes and obesity for both mother and baby. Risk factors for GDM include age, obesity, family history of diabetes, previous history of GDM, ethnicity, multi-fetal pregnancies, and polycystic ovaries. The IADPSG criteria, recommending a 75 g oral glucose tolerance test at 24-28 weeks, is the most accepted screening and diagnostic criterion for GDM. Managing GDM during pregnancy and ensuring postpartum follow-up is crucial to maintain normal glucose levels and prevent complications. This article discusses postpartum testing and highlights strategies based on the Women in India with GDM Strategy project, which achieved a 95.8% postpartum follow-up rate.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Editorial Material
Multidisciplinary Sciences
Viswanathan Mohan, Ranjit Mohan Anjana, Ranjit Unnikrishnan
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Article
Medicine, General & Internal
Amelie Bonnefond, Ranjit Unnikrishnan, Alessandro Doria, Martine Vaxillaire, Rohit N. Kulkarni, Viswanathan Mohan, Vincenzo Trischitta, Philippe Froguel
Summary: Monogenic diabetes encompasses several clinical conditions characterized by early-onset diabetes, including neonatal diabetes, maturity-onset diabetes of the young (MODY) and diabetes-associated syndromes. It can be misdiagnosed as type 2 diabetes, and different genetic variations can lead to different forms of diabetes. Precision medicine approaches and next-generation sequencing have improved diagnosis and treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Review
Endocrinology & Metabolism
Stephen Twigg, Soo Lim, Seung-Hyun Yoo, Liming Chen, Yuqian Bao, Alice Kong, Ester Yeoh, Siew Pheng Chan, Jeremyjones Robles, Viswanathan Mohan, Neale Cohen, Margaret McGill, Linong Ji
Summary: Diabetes is highly prevalent worldwide and in the APAC region, and glucose monitoring is crucial for optimizing diabetes management. The APAC Diabetes Care Advisory Board conducted a survey and expert panel meeting to explore glucose monitoring patterns, patient profiles, benefits, challenges, and potential solutions in the region. The results will guide the formulation of APAC-specific consensus guidelines for continuous glucose monitoring in people with diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Genetics & Heredity
Idrees A. Shah, Rabiya Rashid, Abid Bhat, Haroon Rashid, Rohina Bashir, Mir M. Asrar, Imtiyaz A. Wani, Bashir Ahmad Charoo, Venkatesan Radha, V. Mohan, Mohd Ashraf Ganie
Summary: The hypoglycemia caused by excessive insulin secretion in congenital hyperinsulinemia (CHI) can lead to irreversible brain damage. Mutations in several genes, including ABCC8 and KCNJ11, have been identified as causal. A 3-month-old male infant with seizures and hyperinsulinemia was found to have a novel homozygous missense mutation in the KCNJ11 gene. The identification of such mutations is critical for future therapeutic interventions.
Article
Endocrinology & Metabolism
Viswanathan Mohan, Ganesan Uma Sankari, Anandakumar Amutha, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ranjit Unnikrishnan, Ulagamathesan Venkatesan, Coimbatore Subramanian Shanthi Rani
Summary: This study aimed to compare the clinical and biochemical profile, as well as the prevalence of complications, between childhood/adolescent-onset and adult-onset type 1 diabetes (T1D) at a diabetes center in south India. The data of 5,578 individuals diagnosed with T1D and treated at the center between 1991 and 2021 were analyzed. The results showed that individuals with adult-onset T1D had a higher prevalence of microvascular complications than those with childhood/adolescent-onset T1D, and GAD-negative individuals in the adult-onset group had a higher percentage of retinopathy and chronic kidney disease.
ACTA DIABETOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
