期刊
CYTOKINE
卷 64, 期 3, 页码 638-641出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2013.09.011
关键词
Adiponectin; Autocrine; Macrophages; MicroRNA; Paracrine
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education [NRF-2013R1A1A4A01011110]
- National Research Foundation of Korea(NRF)
- Korea government (MSIP) [2007-0056092]
- National Research Foundation of Korea [2007-0056092, 2013R1A1A4A01011110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Adiponectin, a hormone produced from adipose tissue, regulates various biological responses, including inflammation and many metabolic processes. MicroRNAs control expression of diverse target genes and various physiological responses. Many of these responses are commonly regulated by adiponectin. However, effects of adiponectin on microRNAs regulation are largely unknown. Herein we demonstrated that globular adiponectin induces increase in miR-155 expression, which plays an important role in inflammatory response, in RAW 264.7 macrophages. We further showed that this effect was modulated by and MANK/NF-kappa B dependent mechanisms. These results suggest that miR-155 would be a novel promising target mediating adiponectin-induced various biological responses. (C) 2013 Elsevier Ltd. All rights reserved.
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