Article
Medicine, General & Internal
Xing Song, Yan-Hong Wang, Meng-Tao Li, Xin-Wang Duan, Hong-Bin Li, Xiao-Feng Zeng
Summary: The study on Chinese patients with RA showed high correlations and concordance among different DAIs, but significant discordance was also observed. The four DAIs are not interchangeable in clinical practice for assessing disease activity in RA patients.
CHINESE MEDICAL JOURNAL
(2021)
Review
Rheumatology
Guangyue Zhang, Jiayi Xu, Dongru Du, Yi Liu, Lunzhi Dai, Yi Zhao
Summary: This meta-analysis found that anti-peptidyl arginine deaminase 4 (anti-PAD4) antibody has good diagnostic value in rheumatoid arthritis (RA) and is positively correlated with HLA-SE and negatively correlated with smoking history. Anti-PAD4 antibody can enhance the diagnostic sensitivity of RA and is associated with disease activity and swollen joint count.
Article
Medical Laboratory Technology
Luping Gong, Yinxin Zhou, Shanjun Shi, Lina Ying, Yan Li, Mingcai Li
Summary: IL-41 expression is increased in the serum of RA patients and positively correlated with disease-related parameters. IL-41 may serve as a potential new diagnostic biomarker for RA.
CLINICA CHIMICA ACTA
(2023)
Article
Rheumatology
Katerina Chatzidionysiou, Daniela di Giuseppe, Jonas Soderling, Anca Catrina, Johan Askling
Summary: The study found that patients with RA have a significantly increased risk of developing lung cancer, even after adjusting for smoking. Additionally, rheumatoid factor positivity also contributes to an increased incidence of lung cancer.
Article
Cell Biology
Zhicheng Yang, Weixi Liu, Ting Yan, Ruiping Liu
Summary: The study revealed that HLA-DPB1 rs9277535 polymorphism is associated with a decreased risk of rheumatoid arthritis in the Chinese population, particularly among women and those at least 55 years old. Additionally, certain genotypes were linked to inflammatory markers and levels of HLA-DPB1 plasma and mRNA in RA patients.
Article
Rheumatology
Young Bin Joo, Soo Min Ahn, So-Young Bang, Youngho Park, Su Jin Hong, Youkyung Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Sang-Cheol Bae, Hye-Soon Lee
Summary: The MUC5B variant rs35705950 is a rare but significant risk factor for Asian patients with RA-ILD with usual interstitial pneumonia (UIP), suggesting a shared genetic background between Asian and Western populations.
Article
Medicine, General & Internal
Benedicte Delcoigne, Sella A. Provan, Eirik K. Kristianslund, Johan Askling, Lotta Ljung
Summary: This study aimed to estimate the short-term risks of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) based on their current disease activity, including remission. The results showed that failure to reach remission is associated with an increased risk of ACS, highlighting the importance of optimizing cardiovascular risk factors in these patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Theresa Burkard, Enriqueta Vallejo-Yague, Kim Lauper, Axel Finckh, Thomas Hugle, Andrea M. Burden
Summary: The study found that an increase in BMI may not result in changes in DAS28-esr in patients receiving infliximab, but may lead to a decrease in joint erosions.
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Takahiro Mizuuchi, Tetsuji Sawada, Susumu Nishiyama, Koichiro Tahara, Haeru Hayashi, Hiroaki Mori, Eri Kato, Mayu Tago, Toshihiro Matsui, Shigeto Tohma
Summary: The involvement of distal interphalangeal (DIP) joints in adult-onset rheumatoid arthritis (RA) is associated with disease activity, particularly affecting small-sized and upper-extremity joints.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xianhui Zhang, Pengyan Qiao, Qianyu Guo, Zixie Liang, Jie Pan, Fengping Wu, Xuexue Wang, Liyun Zhang
Summary: This study found that female RA patients had higher FSH levels, which was associated with disease activity. Early menopause may be an important factor in RA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Rheumatology
Antti Palomaki, Aarno Palotie, Jukka Koskela, Kari K. Eklund, Matti Pirinen, Samuli Ripatti, Tarja Laitinen, Nina Mars
Summary: The study utilized Finnish national hospital and biobank databases to link MUC5B variant with increased risk of RA-ILD. In patients with RA, MUC5B promoter variant was also identified as a strong risk factor for ILD.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Jianan Zhao, Lingxia Xu, Cen Chang, Ping Jiang, Kai Wei, Yiming Shi, Linshuai Xu, Yixin Zheng, Yu Shan, Yanqin Bian, Li Li, Shicheng Guo, Steven J. Schrodi, Rongsheng Wang, Dongyi He
Summary: This study found a significant hypermethylation of the promoter region of HTR2A, indicating its potential clinical diagnostic role in rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu, Zongwen Shuai
Summary: The study explored the association between TTP gene polymorphisms and mRNA levels with RA susceptibility in Chinese populations. The results indicated that the T allele of rs3746083 in the TTP gene increased susceptibility to RA, with a significant difference found under the dominant model. However, the association of rs251864 with RA was not statistically significant. Furthermore, TTP expression levels were significantly reduced in RA patients, supporting its potential involvement in RA pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
John Bedson, Ying Chen, Julie Ashworth, Richard A. Hayward, Kate M. Dunn, Kelvin P. Jordan
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Cell Biology
Jin Shang, Qianxin He, Ying Chen, Dahai Yu, Lulu Sun, Genyang Cheng, Dong Liu, Jing Xiao, Zhanzheng Zhao
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Medical Informatics
John Bedson, Jonathon Hill, David White, Ying Chen, Simon Wathall, Stephen Dent, Kendra Cooke, Danielle van der Windt
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2019)
Article
Anesthesiology
Alessandro Andreucci, Paul Campbell, Emily Richardson, Ying Chen, Kate M. Dunn
EUROPEAN JOURNAL OF PAIN
(2020)
Article
Primary Health Care
J. C. Hill, S. Garvin, Y. Chen, V Cooper, S. Wathall, B. Saunders, M. Lewis, J. Protheroe, A. Chudyk, K. M. Dunn, E. Hay, D. van der Windt, C. Mallen, N. E. Foster
BMC FAMILY PRACTICE
(2020)
Article
Primary Health Care
Ying Chen, Richard Hayward, Carolyn A. Chew-Graham, Richard Hubbard, Peter Croft, Keith Sims, Kelvin P. Jordan
BRITISH JOURNAL OF GENERAL PRACTICE
(2020)
Article
Sport Sciences
Yan Chen, Ying Chen, Baohua Geng, Yong Zhang, Rui Qin, Yamei Cai, Feng Bai, Dahai Yu
Summary: The study found that moderate-to-vigorous physical activity is inversely associated with abnormal liver function in Chinese adults, suggesting promoting such activities could be a cost-effective strategy in maintaining liver health.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2021)
Article
Endocrinology & Metabolism
Lirong Lu, Ying Chen, Yamei Cai, Tao Chen, Yi Huang, Huaxi Meng, Dahai Yu
Summary: The study found a non-linear relationship between fasting glucose level and physical activity level among adults with abnormal glucose metabolism, with an inverse association observed only after reaching a certain threshold level of physical activity.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Immunology
Jing Wang, Abram L. Wagner, Ying Chen, Etienne Jaime, Xinwen Hu, Shiqiang Wu, Yihan Lu, Yuhua Ruan, Stephen W. Pan
Summary: The study found that a Health Code-based vaccine mandate in China can increase willingness to vaccinate for COVID-19, especially among vaccine hesitators. Willingness to vaccinate significantly increased when vaccine efficacy was greater than 60%.
Article
Cardiac & Cardiovascular Systems
Kelvin P. Jordan, Trishna Rathod-Mistry, James Bailey, Ying Chen, Lorna Clarson, Spiros Denaxas, Richard A. Hayward, Harry Hemingway, Danielle A. van der Windt, Mamas A. Mamas
Summary: This study aimed to assess whether patients with unattributed chest pain presenting to primary care have an increased risk of cardiovascular events and to determine whether interventions are targeted at those at higher risk. The study found that patients with unattributed chest pain had an increased risk of cardiovascular events, and the primary prevention for those at higher risk was suboptimal.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Ying Chen, Lanwei Zhang, Tenglong Li, Li Li
Summary: This study used structural equation modeling to analyze the impact of COVID-19 vaccine allocation on health inequality. The study found that populations characterized by social vulnerabilities received less vaccination and were more affected by COVID-19. The unequal distribution of vaccines led to additional inequality in COVID-19 mortality.
Article
Biology
Xiangning Dong, Jingxian Huang, Yanze Yi, Lanwei Zhang, Tenglong Li, Ying Chen
Summary: Our study aimed to identify pathways from the source of information to the uptake of cancer genetic testing, with consideration of intermediate variables including perceptional, attitudinal, and psychosocial factors. Our findings suggest that only information from particular sources, such as healthcare providers and genetic counselors, had positive and significant effects on people's perceptions of cancer regarding its prevention, detection, and treatment. Attitudinal and psychosocial factors showed much smaller or insignificant effects on the uptake of genetic testing.
Article
Engineering, Environmental
Bingjie Qu, Shiqiang Wu, Peng Zhao, Zheng Feei Ma, Royston Goodacre, Linxi Yuan, Ying Chen
Summary: This study aimed to determine common patterns of geographic distribution of health-related minerals in the USA and evaluate their cumulative effects on overall population health. Using county-level data on concentrations of 14 minerals in stream sediments and overall health measurements, latent class analysis identified three clusters of life expectancy-related minerals. The 'infertile' cluster was associated with the shortest life expectancy, highest mortality risks at all ages, and highest mortality rates for various causes. The study provides novel insights into environmental geochemistry and its impact on health disparities in the USA.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Immunology
Tenglong Li, Zilong Wang, Shuyue He, Ying Chen
Summary: To evaluate the effectiveness of COVID-19 vaccination, it is important to separate the herd effect and marginal effect and parameterize them separately. Through studying the relationship between COVID-19 vaccination coverage and case fatality rate (CFR) at the county level in the U.S., we found three breakpoints where herd effects could potentially exist. Our results highlight the need for public-health researchers to differentiate and quantify the herd and marginal effects when analyzing vaccination data, to inform vaccination strategies and evaluate effectiveness.
Article
Health Care Sciences & Services
Jonathan Hill, Stefannie Garvin, Ying Chen, Vincent Cooper, Simon Wathall, Bernadette Bartlam, Benjamin Saunders, Martyn Lewis, Joanne Protheroe, Adrian Chudyk, Hollie Birkinshaw, Kate M. Dunn, Sue Jowett, Raymond Oppong, Elaine Hay, Danielle van der Windt, Christian Mallen, Nadine E. Foster
JMIR RESEARCH PROTOCOLS
(2020)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
