Article
Environmental Sciences
Miki Kuroiwa, Shin-Ichiro Yamaguchi, Yoshinobu Kato, Arisa Hori, Saori Toyoura, Mai Nakahara, Nobuyuki Morimoto, Masafumi Nakayama
Summary: Our study demonstrates that the receptor Tim4 mediates the interaction between macrophages and microplastics through aromatic-aromatic interactions. It is involved in the engulfment of PS microplastics and MWCNTs, and disrupts the process of efferocytosis. These findings suggest that chronic exposure to large amounts of PS microplastics may lead to chronic inflammation and autoimmune diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Clinical Neurology
Peijie Fu, Manqing Zhang, Moxin Wu, Weixin Zhou, Xiaoping Yin, Zhiying Chen, Chuanjun Dan
Summary: Non-traumatic intraparenchymal brain hemorrhage, also known as intracerebral hemorrhage (ICH), is associated with a high rate of disability and case fatality. Active intervention can significantly lower the rate of severe disability. The speed of hematoma clearance after ICH is crucial for determining the patient's prognosis. Surgical or medication-only conservative treatment is chosen based on the hematoma volume and mass effect. Promoting endogenous hematoma absorption is a more relevant goal due to the limited number of suitable patients for surgery and the additional trauma it may cause. Understanding the mechanisms and key targets for clinical purposes is necessary for the future removal of hematoma after ICH.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He
Summary: While SR-A1 aids in the uptake of Leptospira by macrophages, it may be utilized by the pathogen to modulate inflammatory responses and increase susceptibility to infection in the host.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Genetics & Heredity
Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu
Summary: The study found that while Msr1 expression is upregulated in prion-infected mouse brains, deficiency of Msr1 does not impact disease progression or lesion patterns. This suggests that Msr1 does not play a major role in prion pathogenesis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Fisheries
Li-Zhen Zhou, Rui-Juan Wang, You-Ying Yan, Shuocheng Zeng, Zhen Zou, Zhiqiang Lu
Summary: Scavenger receptors (SRs) are essential for phagocytosis in the immune system, playing a key role in recognizing pathogens. MmSR-B1, a member of the SR family from parasitic wasps, responds to bacterial infection and mediates phagocytosis and the production of antimicrobial peptides (AMPs). Knockdown of MmSR-B1 impairs hemocyte phagocytosis and downregulates AMP gene expression, leading to increased mortality of the wasps when challenged by bacteria.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Gaoqian Feng, Liriye Kurtovic, Paul A. Agius, Elizabeth H. Aitken, Jahit Sacarlal, Bruce D. Wines, P. Mark Hogarth, Stephen J. Rogerson, Freya J. Fowkes, Carlota Dobano, James G. Beeson
Summary: The study provides new insights into the modest and time-limited efficacy of RTS,S in children and the induction of antibody functional activities. Improving the induction and maintenance of antibodies that promote phagocytosis and cellular functions, as well as combating the negative effect of malaria exposure on vaccine responses, are potential strategies for improving the efficacy and longevity of RTS,S.
Article
Chemistry, Multidisciplinary
Mai T. Huynh, Carole Mikoryak, Paul Pantano, Rockford Draper
Summary: The study found that replacing the PF108 coating with bovine serum albumin (BSA) resulted in both cMWNTs and pMWNTs being able to bind to and accumulate in RAW 264.7 macrophages, with cMWNTs showing greater interaction than pMWNTs. Knocking out SR-A1 in RAW 264.7 cells using CRISPR-Cas9 technology significantly reduced the binding and accumulation of both BSA-coated cMWNTs and pMWNTs.
Article
Medicine, Research & Experimental
Megha Srinivas, Preeti Sharma, Siddharth Jhunjhunwala
Summary: Research findings suggest that immune cells can phagocytose particles under constant fluidic flow. Different cell types show similar or better uptake rates under flow conditions. Even in the presence of crowded red blood cells, neutrophils and monocytes are able to uptake particles while flowing.
MOLECULAR PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Evangelos Triantafyllou, Cathrin L. C. Gudd, Marie-Anne Mawhin, Hannah C. Husbyn, Francesca M. Trovato, Matthew K. Siggins, Thomas O'Connor, Hiromi Kudo, Sujit K. Mukherjee, Julia A. Wendon, Christine Bernsmeier, Robert D. Goldin, Marina Botto, Wafa Khamri, Mark J. W. McPhail, Lucia A. Possamai, Kevin J. Woollard, Charalambos G. Antoniades, Mark R. Thursz
Summary: The PD-1/PD-L1 pathway regulates KC and monocyte antimicrobial responses after acute liver injury, suppressing immune response and increasing susceptibility to infections.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi
Summary: CD36 plays an important role in podocyte injury in lupus nephritis by activating NLRP3 inflammasome and inhibiting autophagy, and enhancing autophagy can decrease NLRP3 inflammasome and alleviate podocyte injury.
CELL DEATH & DISEASE
(2022)
Article
Fisheries
Shun Yang, Yuanxin Ma, Xiaocong Lou, Zhewei Zhou, Huimin Zhang, Shunfa Yi, Yan Cheng, Shichao Qian, Mengmeng Huang, Hui Fei
Summary: The phagocytic capacity of largemouth bass leukocytes, particularly granulocytes/monocytes, was observed against fluorescent microspheres and Aeromonas hydrophila. Up-regulation of phagocytosis-related genes and TNF-alpha was observed in the leukocytes following A. hydrophila stimulation. Recombinantly expressed TNF-alpha in largemouth bass significantly enhanced the phagocytic ability of granulocytes/monocytes and increased their ROS activity, while also inducing apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Microbiology
Bishnu Prasad Sinha, Priyanka Mehta, Md Asmaul Hoque, Purbita Bandopadhyay, Ayandip Nandi, Ipsita Saha, Anita Nandi Mitra, Asish Mondal, Boudhayan Bhattacharjee, Georgios Chamilos, Rajesh Pandey, Kaushik Basu, Dipyaman Ganguly
Summary: Cases of rhino-orbital mucormycosis in COVID-19 patients have been reported, but the specific immune mechanisms underlying susceptibility to this infection remain unexplored. This study aimed to investigate the regulation of circulating cytokines in COVID-19-associated mucormycosis (CAM) patients and its potential pathogenic links with myeloid phagocyte function and susceptibility to mucormycosis.
Article
Immunology
Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, Yoshio Yamauchi, Yumiko Tsukamoto, Takeshi Ichinohe, Etsuko Fujita, Ryosuke Hiranuma, Ryutaro Fukui, Yoichi Furukawa, Toshio Kitamura, Toshiyuki Takai, Arinobu Tojo, Mamitaro Ohtsuki, Umeharu Ohto, Toshiyuki Shimizu, Manabu Ozawa, Nobuaki Yoshida, Toshiaki Isobe, Eicke Latz, Kojiro Mukai, Tomohiko Taguchi, Hiroaki Hemmi, Shizuo Akira, Kensuke Miyake
Summary: Loss-of-function mutations in SLC29A3 cause histiocytic diseases, which are driven by TLR7 and TLR8, endosomal sensors for nucleosides and oligoribonucleotides. TLR7 promotes the proliferation and maturation of monocytes, leading to the accumulation of phagocytes and histiocytosis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Elena Kazakova, Pavel Iamshchikov, Irina Larionova, Julia Kzhyshkowska
Summary: Tumor-associated macrophages (TAMs), a heterogeneous population of myeloid cells, interact with tumor microenvironment (TME) components through scavenger receptors (SRs). In this review, we summarize the role of macrophage SRs in tumor development and their significance as cancer biomarkers. We focus on the functional activity of TAM-expressing SRs in animal models and patients, and provide data on the prognostic significance of these SRs in different human cancer types.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Sarah To, Thandiwe Chavula, Mesias Pedroza, Jennifer Smith, Sandeep K. Agarwal
Summary: CDH11 plays an important role in pulmonary fibrosis by regulating macrophage development, M2 polarization, and phagocytic function.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Respiratory System
Ivan Castellvi, Silvia Vidal, Claudia Valenzuela
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Oncology
Carlos Zamora Atenza, Georgia Anguera, Mariona Riudavets Melia, Leticia Alserawan De Lamo, Ivana Sullivan, Andres Barba Joaquin, Jorgina Serra Lopez, M. Angels Ortiz, Maria Mulet, Silvia Vidal, Margarita Majem
Summary: This study analyzed the predictive effect of integrating systemic and tumor PD-L1 in patients with advanced NSCLC receiving PD-(L)1 blockade agents. The results showed that integrating circulating and tumor PD-L1 data can help in deciding the best treatment strategy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ana MicaelaCarnaz Simoes, Morten Orebo Holmstrom, Pia Aehnlich, Anne Rahbech, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjaer, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per Thor Straten
Summary: This study investigates the frequencies of circulating platelet (PLT)-lymphocyte aggregates in myeloproliferative neoplasms (MPN) patients and the impact of PLT binding on CD8 T cell function. The results show significantly higher frequencies of PLT-CD8 T cell aggregates in MPN patients and reduced proliferation and cytotoxic capacity in PLT-bound CD8 T cells. The findings suggest compromised CD8 T cell responses in MPN patients due to PLT binding, possibly contributing to disease progression and increased susceptibility to infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Maria Mulet, Ruben Osuna-Gomez, Carlos Zamora, Jose M. Porcel, Juan C. Nieto, Lidia Perea, Virginia Pajares, Ana M. Munoz-Fernandez, Nuria Calvo, Maria Alba Sorolla, Silvia Vidal
Summary: This study provides novel information about the role of neutrophils in malignant pleural effusion (MPE) and their clinical relevance. Neutrophils contribute to tumor progression through the release of neutrophil extracellular traps (NETs) and are associated with worse outcomes in lung adenocarcinoma patients with MPE.
Article
Immunology
Ruben Osuna-Gomez, Silvia Barril, Maria Mulet, Carlos Zamora Atenza, Paloma Millan-Billi, Ana Pardessus, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Diego Castillo, Silvia Vidal
Summary: This study aims to investigate the immune regulatory role of IL-35 in the development of fibrosis in interstitial lung disease (ILD). The results suggest that IL-35 may induce an anti-fibrotic response, regulating the effect of TGF-beta and the inflammatory response on CD4+ T cells. Furthermore, the TGF-beta: IL-35 ratio in BAL has been shown to be a potential biomarker to predict the outcome of F patients with ILD.
Article
Biochemistry & Molecular Biology
Leticia Alserawan, Georgia Anguera, Carlos Zamora Atenza, Jorgina Serra Lopez, Laura Martinez-Martinez, Mariona Riudavets Melia, Ivana Sullivan, Andres Barba Joaquin, Margarita Majem Tarruella, Silvia Vidal
Summary: Immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICI) are unpredictable autoimmune-like toxicities. This study found that the appearance of antinuclear autoantibodies (ANAs) during ICI treatment may predict the severity of irAEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Miriana d'Alessandro, Sara Gangi, Piera Soccio, Elisabet Canto, Ruben Osuna-Gomez, Laura Bergantini, Paolo Cameli, Gaia Fabbri, Sara Croce, Giulia Scioscia, Giusy Montuori, Matteo Fanetti, Giorgia Moriondo, Fabrizio Mezzasalma, Diego Castillo, Donato Lacedonia, Silvia Vidal, Elena Bargagli
Summary: This study investigated extracellular vesicle markers in bronchoalveolar lavage (BAL) samples from patients with interstitial lung diseases. It was found that these markers were related to fibrotic damage and were shared among different lung diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Luca Laghi, Eva Roman, Qiuyu Lan, Juan Camilo Nieto, Aleix Canalda-Baltrons, Maria Poca, Maria B. Sanchez-Rodriguez, Joan Claria, Edilmar Alvarado, Berta Cuyas, Elisabet Sanchez, Silvia Vidal, Carlos Guarner, Angels Escorsell, Chaysavanh Manichanh, German Soriano
Summary: In this study, we analyzed the blood metabolome of cirrhotic patients to investigate the potential mechanisms of a probiotic. We found that the multistrain probiotic may influence glutamine/glutamate metabolism, increasing the detoxification capacity of ammonia.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ruben Osuna-Gomez, Ivan Castellvi, Maria Mulet, Ma Angels Ortiz, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Silvia Vidal
Summary: This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. The study found significantly lower plasma IL-35 concentrations in SSc patients, and the levels of IL-35 showed a negative correlation with TGF-beta and IL-17. Flow cytometry analysis revealed higher levels of IL-35 receptor expression on monocytes and lower levels on CD8+ T cells in SSc patients. The addition of recombinant IL-35 reduced the percentage of IL-17+CD4+ T cells and increased the percentage of IL-35+CD4+ T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Hematology
N. Lopez, C. Zamora, M. Montoya, C. Gabara, M. Ortiz, J. Aibar
THROMBOSIS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
