期刊
CYTOKINE
卷 59, 期 3, 页码 451-459出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2012.06.014
关键词
Cytokines; TNF superfamily; Interleukins; Intestinal inflammationl; Inflammatory bowel disease
资金
- NIDDK NIH HHS [R56 DK042191, R01 DK055812, R37 DK042191, R01 DK056762, R01 DK042191, P01 DK091222] Funding Source: Medline
In addition to their well-known role in acute injury and chronic inflammation, innate cytokines play an important role in health and the maintenance of normal immune homeostasis. This group includes the prototypic cytokines IL-1 and TNF alpha, as well as several other members belonging to the IL-1 and TNF family, such as IL-18, IL-33, IL-36-38, and TL1A. The dichotomous role of these cytokines has been best characterized in the intestine where innate cytokines may play both a protective and a pro-inflammatory role, depending upon the immmunological status of the host or the type and phase of the inflammatory process. This new information has produced novel pathogenetic hypotheses that have important translational implications both in regard to the prevention and treatment of chronic intestinal inflammation, including Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease. This review will discuss and summarize current data regarding the role of IL-1, TNF alpha, and their family members in regulating gut mucosal homeostasis and chronic intestinal inflammation. (C) 2012 Published by Elsevier Ltd.
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