Article
Endocrinology & Metabolism
Li-Hsin Chang, Chia-Huei Chu, Chin-Chou Huang, Liang-Yu Lin
Summary: This study found that FGF-21 levels were associated with an increased risk of renal events in Chinese patients with T2DM. FGF-21 may serve as a potential biomarker to predict renal outcomes in T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: FGF21 is a hormone synthesized and released from the liver. In type 2 diabetes, FGF21 is released to overcome insulin resistance stimulated by inflammation. Metformin increases FGF21 expression and improves its sensitivity, thereby improving insulin sensitivity and glucose homeostasis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Anne Kathrine Nissen Pedersen, Lars Christian Gormsen, Soren Nielsen, Niels Jessen, Mette Bjerre
Summary: The study found that treatment with metformin in patients with type 2 diabetes can suppress circulating FAP activity, increase the expression of FGFR1c and beta-klotho, and improve the sensitivity of adipose tissue to FGF21.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Rui Li, Beini Wang, Chengbiao Wu, Duohui Li, Yanqing Wu, Libing Ye, Luxia Ye, Xiongjian Chen, Peifeng Li, Yuan Yuan, Hongyu Zhang, Ling Xie, Xiaokun Li, Jian Xiao, Jian Wang
Summary: This study found that in a T2DM mouse model, the expression of aFGF rapidly decreased. Administration of exogenous aFGF was able to prevent acute demyelination and nerve fiber disorganization, primarily through increasing Schwann cell proliferation and migration, as well as suppressing apoptosis. The beneficial effects of aFGF on Schwann cell behavior and abnormal myelin morphology were likely due to the inhibition of hyperglycemia-induced oxidative stress activation.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study revealed a negative association between serum FGF19 level and diabetic retinopathy in patients with T2DM, suggesting a potential predictive value.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Neurosciences
Liangcai Zhao, Haowei Jiang, Jiaojiao Xie, Danjie Shen, Qingqing Yi, Jiapin Yan, Chen Li, Hong Zheng, Hongchang Gao
Summary: In this study, the effects and mechanisms of FGF21 on DACD were investigated in a mouse model. It was found that FGF21 treatment improved lactate utilization and uptake, leading to improvements in learning and memory. These effects were mediated by increased LDH-B activity, ATP levels, and PI3K signaling pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaojiao Jia, Liwei Bai, Ning Ma, Qiang Lu
Summary: This study investigated the differences in serum fibroblast growth factor-21 (FGF-21) levels between pregnant women with normal glucose tolerance and gestational diabetes mellitus (GDM). It also analyzed the relationship between FGF-21 and glucose and lipid metabolic indicators, leptin, retinol binding protein 4 (RBP-4), and adiponectin in GDM. The results showed that GDM group had higher FGF-21 levels, which may be related to pre-pregnancy BMI, weight gain during pregnancy, leptin, RBP-4, and adiponectin.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Yinai Liu, Qianqian Chen, Yaoqi Li, Liuliu Bi, Zhiying He, Chuxiao Shao, Libo Jin, Renyi Peng, Xingxing Zhang
Summary: Diabetes is a serious disease that threatens global human health. Insulin is the most effective treatment, but it can cause hypoglycemia and insulin resistance. Recent studies have found that fibroblast growth factors can safely and effectively reduce hyperglycemia, providing a new approach for diabetes treatment.
Article
Endocrinology & Metabolism
L. -H. Chang, C. -M. Hwu, C. -H. Chu, Y. -C. Lin, C. -C. Huang, J. -Y. You, H. -S. Chen, L. -Y. Lin
Summary: The study found that levels of sTNFR1 and FGF-21 were associated with renal outcomes in patients with type 2 diabetes, and the combination of both markers exhibited better predictability.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Esmeralda Castelblanco, Marta Hernandez, Nuria Alonso, Aina Ribes-Betriu, Jordi Real, Minerva Granado-Casas, Joana Rossell, Marina Idalia Rojo-Lopez, Adriana Silvia Dusso, Josep Julve, Didac Mauricio
Summary: This study found that higher levels of alpha-klotho are associated with subclinical carotid atherosclerosis in the absence of kidney dysfunction, suggesting a new pathophysiological pathway involved in the development and progression of this complication.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Lili You, Xiaosi Hong, Hongshi Wu, Diefei Liang, Feng Li, Dinghao Zheng, Xiuwei Zhang, Dan Liu, Qingyu Chen, Li Yan, Meng Ren, Wei Wang
Summary: This study showed that high levels of FGF-21 were associated with an increased risk of newly diagnosed type-2 diabetes mellitus. FGF-21 levels could be an important biomarker for the assessment of diabetes risk.
BMC ENDOCRINE DISORDERS
(2023)
Article
Nanoscience & Nanotechnology
Jie Zhou, Xinwei Chen, Qiong Chen, Beibing Pan, Jiaxin Lou, Zhenyu Jia, Yali Du, Wenxin Xu, Lu Zhang, Xin Feng, Lingwei Jin, Mengru Shi, Xiaokun Li, Zhifeng Huang, Jian Sun
Summary: Drugs for metabolic diseases often have systemic side effects. In this study, a novel FGF1 Delta HBS conjugate targeted to skeletal muscle was developed, which showed minimal side effects and a glucose-lowering effect in diabetic mice.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Endocrinology & Metabolism
Jin Hee Kim, Gha Young Lee, Hyo Jin Maeng, Hoyoun Kim, Jae Hyun Bae, Kyoung Min Kim, Soo Lim
Summary: The study revealed that a low-dose combination of GLP-1 analogue and FGF21 can significantly reduce atherosclerotic plaque formation, lower body weight, glucose, and leptin levels, and increase adiponectin levels. The combination treatment also affects various pathways related to atherosclerosis.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Environmental Sciences
Sin-Yi Huang, Du-An Wu, Jen-Pi Tsai, Bang-Gee Hsu
Summary: The study evaluated the relationship between serum FGF-21 levels and AS in type 2 diabetes mellitus patients, finding that serum FGF-21 level along with systolic blood pressure were independent predictors of AS.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Sum Lam, David Tak Wai Lui, Sammy Wing Ming Shiu, Ying Wong, Kathryn Choon Beng Tan
Summary: IDOL acts as a post-transcriptional degrader of the LDL receptor. In individuals with type 2 diabetes, the expression of IDOL is decreased and associated with glycemia and serum FGF21 concentration. Downregulation of IDOL may affect cytokine production in monocyte-derived macrophages.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Endocrinology & Metabolism
Kejia Li, Xin Liao, Kuan Wang, Qiao Mi, Tingran Zhang, Yanjun Jia, Xiaohuei Xu, Xiaoheu Luo, Cheng Zhang, Hua Liu, Hongting Zhen, Ling Li, Gangyi Yang
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Cell Biology
Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li, Gangyi Yang
CELL DEATH & DISEASE
(2017)
Article
Oncology
Han Wang, Lin Du, Tong Wu, Gangyi Yang, Wenjing Hu, Hansheng Wang, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Zhiming Zhu, Hongting Zheng, Ling Li
Article
Oncology
Yang Peng, Guo-Chao Zhong, Qiao Mi, Kejia Li, Ao Wang, Ling Li, Hua Liu, Gangyi Yang
Article
Peripheral Vascular Disease
Hong Huang, Wei Wang, Gangyi Yang, Yu Zhang, Xiaoqiang Li, Hua Liu, Lin Zhang, Hongting Zheng, Ling Li
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
(2018)
Article
Biotechnology & Applied Microbiology
Fanping Meng, Yao Lin, Min Yang, Minyan Li, Gangyi Yang, Po Hao, Ling Li
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Xiaohui Xu, Xiaoqiang Li, Gangyi Yang, Ling Li, Wenjing Hu, Lili Zhang, Hua Liu, Hongting Zheng, Minghong Tan, Danping Zhu
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Cheng Zhang, Xiaohe Luo, Jianrong Chen, Baoyong Zhou, Mengliu Yang, Rui Liu, Dongfang Liu, Harvest F. Gu, Zhiming Zhu, Hongting Zheng, Ling Li, Gangyi Yang
Article
Biochemistry & Molecular Biology
Yerui Lai, Anjiang Zhao, Minghong Tan, Mengliu Yang, Yao Lin, Shengbing Li, Jinlin Song, Hongting Zheng, Zhiming Zhu, Dongfang Liu, Chaohong Liu, Ling Li, Gangyi Yang
Article
Endocrinology & Metabolism
Yang Li, Mingyuan Tian, Mengliu Yang, Gangyi Yang, Jianrong Chen, Han Wang, Dongfang Liu, Hongyan Wang, Wuquan Deng, Zhiming Zhu, Hongting Zheng, Ling Li
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Endocrinology & Metabolism
Shan Yang, Han Dai, Wenjing Hu, Shan Geng, Ling Li, Xinrun Li, Hua Liu, Dongfang Liu, Ke Li, Gangyi Yang, Mengliu Yang
Summary: This study found that serum FSTL-1 levels were significantly higher in patients with newly diagnosed MetS than in controls, and were significantly associated with MetS components and insulin resistance. Bioinformatics analysis identified core genes and pathways associated with FSTL-1, and serum FSTL-1 levels were positively correlated with fasting plasma glucose, waist circumference, blood pressure, triglyceride levels, and visceral adiposity index.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Xiaohui Xu, Tingran Zhang, Mani Mokou, Ling Li, Peng Li, Jinlin Song, Hua Liu, Zhiming Zhu, Dongfang Liu, Mengliu Yang, Gangyi Yang
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Mengliu Yang, Sheng Qiu, Yirui He, Ling Li, Tong Wu, Ning Ding, Fanghong Li, Allan Z. Zhao, Gangyi Yang
Summary: The study provides genetic evidence that CRP plays a direct role in regulating energy balance, body weight, insulin sensitivity, and glucose homeostasis by influencing leptin's central effect and hypothalamic signaling.
Article
Engineering, Biomedical
Shan Geng, Limei Qin, Yirui He, Xinrun Li, Mengliu Yang, Ling Li, Dongfang Liu, Yongsheng Li, Dechao Niu, Gangyi Yang
Summary: The use of amino-functionalized and embedded dual-mesoporous silica nanoparticles (N-EDMSNs) to simultaneously carry liraglutide and FGF-21 resulted in significant biological effects in high-fat diet fed mice, including reduced food intake, body weight, and blood glucose, increased energy expenditure and improved hepatic insulin resistance.
Article
Endocrinology & Metabolism
Min Long, Leiqin Cai, Wenjie Li, Linlin Zhang, Shaodong Guo, Rui Zhang, Yi Zheng, Xiufei Liu, Min Wang, Xianli Zhou, Hui Wang, Xing Li, Ling Li, Zhiming Zhu, Gangyi Yang, Hongting Zheng
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.