Article
Biochemistry & Molecular Biology
Victor Antonio Blanco-Palmero, Marcos Rubio-Fernandez, Desiree Antequera, Alberto Villarejo-Galende, Jose Antonio Molina, Isidro Ferrer, Fernando Bartolome, Eva Carro
Summary: CSF levels of YKL-40 are significantly increased in the dementia stages of AD, consistent with increased astrogliosis. These neuroinflammation biomarkers are differently detected in CSF from AD and PD patients.
Article
Cardiac & Cardiovascular Systems
Mowei Song, Guofu Zhang, Hang Shi, Erjun Zhu, Li Deng, Hongtao Shen
Summary: This study found a positive association between serum YKL-40 levels and inflammatory cytokines and the Gensini score in patients with coronary heart disease (CHD). When YKL-40 levels exceeded 100 and 150 ng/ml, it indicated a higher risk of major adverse cardiovascular events (MACE) in CHD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria Gevezova, Maria Kazakova, Anastasia Trenova, Victoria Sarafian
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. There is growing evidence suggesting that mitochondrial dysfunction and inflammation play a crucial role in the pathogenesis of PD. This study investigated the metabolic profile of peripheral blood mononuclear cells (PBMCs) from PD patients and found changes in mitochondrial activity and YKL-40 levels in PD patients. The protein levels of YKL-40 were threefold higher in PD and showed a correlation with basal respiration and ATP production. These findings suggest an interplay between YKL-40 and mitochondrial function in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jiejie Li, Jinxi Lin, Yuesong Pan, Mengxing Wang, Xia Meng, Hao Li, Yilong Wang, Xingquan Zhao, Haiqiang Qin, Liping Liu, Yongjun Wang
Summary: The study found that IL-6 and YKL-40 were independently associated with recurrent stroke and poor functional outcome, and improved risk classification of clinical risk algorithms.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Zahra Darabi, Seyed Mostafa Seyed Hosseini, Mohammadtaghi Sarebanhassanabadi, Sara Jambarsang, Mohammad Yahya Vahidi Mehrjardi, Mahdieh Hosseinzadeh, Sara Beigrezaei, Azam Ahmadi Vasmehjani, Marzieh Taftian, Vahid Arabi, Maryam Motallaei, Faezeh Golvardi Yazdi, Amin Salehi-Abargouei, Azadeh Nadjarzadeh
Summary: This study examined the interaction of dietary patterns and genes on coronary angiography results in Iranians. It found that high adherence to a traditional dietary pattern was associated with an increased risk of coronary artery stenosis for individuals with a specific gene variant. This study lays the foundation for future research on gene-diet interactions.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Kalthoum Tizaoui, Jae Won Yang, Keum Hwa Lee, Ji Hong Kim, Minseok Kim, Sojung Yoon, Yeonwoo Jung, Joon Beom Park, Kitae An, Hyeok Choi, Donggyu Song, HyunTaek Jung, Seongmin Ahn, Taeho Yuh, Hee Min Choi, Jae Ha Ahn, Younjuong Kim, Sanghyun Jee, Hyeongsun Lee, Soohwa Jun, Jun-Gu Kang, Bohyun Koo, Joo Yeop Lee, Kyoung Min Min, Wonseok Yoo, Hyeong Jun Rhyu, Yeonjung Yoon, Min Ho Lee, Sung Eun Kim, Jimin Hwang, Ai Koyanagi, Louis Jacob, Seoyeon Park, Jae Il Shin, Lee Smith
Summary: YKL-40, also known as CHI3L1 or HC gp-39, is a protein expressed by various cell types and speculated to be related to inflammatory reactions and autoimmune diseases. Studies have shown its potential as a marker for disease diagnosis, prognosis, disease activity, and treatment response, particularly in rheumatoid arthritis and psoriasis, but further research is needed to elucidate its exact role in autoimmunity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang, Andrew M. Chan
Summary: This study found that increased expression of YKL-40 in astrocytes is associated with activated astrocytes in an Alzheimer's disease model. A beta 1-42 upregulates YKL-40 through the PI3-K signaling pathway in primary astrocytes, leading to synaptic degeneration and impaired neuronal function. Knockout of YKL-40 in astrocytes reduces amyloid plaque deposition, attenuates glial activation, reduces neuronal attrition, and restores memory function in symptomatic Alzheimer's disease mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Barbara Radovani, Frano Vuckovic, Aldo P. Maggioni, Ele Ferrannini, Gordan Lauc, Ivan Gudelj
Summary: This study investigated the association between N-glycosylation of immunoglobulin G (IgG) and coronary artery disease (CAD). The analysis revealed differences in IgG N-glycome composition between CAD+ and CAD- cases, particularly in women, where sialylated N-glycan structures were negatively associated with CAD.
Article
Cell Biology
Antti Laurikka, Katriina Vuolteenaho, Vesa Toikkanen, Timo Rinne, Tiina Leppanen, Mari Hamalainen, Matti Tarkka, Jari Laurikka, Eeva Moilanen
Summary: The aim of this study was to investigate the levels of YKL-40 during and after CABG and its associations with oxidative stress, inflammation, and myocardial injury markers. The results showed that YKL-40 levels were significantly increased 24 hours after CPB, and there were positive correlations between YKL-40 and post-operative TnT, as well as with chemotactic factors MCP-1 and IL-8. YKL-40 may play a role as a factor and/or biomarker of myocardial inflammation, injury, and subsequent fibrosis following heart surgery.
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhan Jing-Lun, Chai Shuang, Zhao Li-Mei, Liu Xiao-Dong
Summary: This study found that YKL-40 promotes the expression of downstream chemokines CCL2 and IP-10 by activating the TF-PAR1 pathway, leading to increased recruitment of inflammatory cells and exacerbating the progression of liver injury. This provides a new approach for the clinical treatment of drug-induced liver injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Dilara Bal Topcu, Gokcen Tugcu, Berrin Er, Sanem Eryilmaz Polat, Mina Hizal, Ebru Elmas Yalcin, Deniz Dogru Ersoz, Lutfi Coplu, Ugur Ozcelik, Nural Kiper, Incilay Lay, Yesim Oztas
Summary: In patients with cystic fibrosis lung disease, both pediatric and adult patients showed significantly elevated levels of YKL-40 and CHIT1 activity compared to controls, suggesting a potential role in CF pathology. Interestingly, adult patients had higher CHIT1 activity compared to controls, while pediatric patients had similar CHIT1 activity to controls. YKL-40 levels were negatively correlated with lung function parameters in both pediatric and adult patients during exacerbation period.
Article
Clinical Neurology
Wiesje Pelkmans, Mahnaz Shekari, Anna Brugulat-Serrat, Gonzalo Sanchez-Benavides, Carolina Minguillon, Karine Fauria, Jose Luis Molinuevo, Oriol Grau-Rivera, Armand Gonzalez Escalante, Gwendlyn Kollmorgen, Margherita Carboni, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Marc Suarez-Calvet, Juan Domingo Gispert
Summary: We studied the role of biomarkers of reactive astrogliosis in the pathogenic cascade of Alzheimer's disease. Various fluid biomarkers were found to influence the progression of the disease, with GFAP mediating the association between soluble and insoluble Aβ, and YKL-40 partly explaining the association between Aβ and downstream tau pathology and neuronal injury.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Weikang Bian, Xiao-Xin Jiang, Zhicheng Wang, Yan-Rong Zhu, Hongsong Zhang, Xiaobo Li, Zhizhong Liu, Jing Xiong, Dai-Min Zhang
Summary: This study constructed an lncRNA-miRNA-mRNA regulatory network for coronary artery disease (CAD), identified differentially expressed genes, and explored key nodes in the ceRNA network. The findings suggest that these genes are mainly involved in nitrogen compound metabolic process, PI3K-Akt signaling pathway, and retrograde endocannabinoid signaling.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Hasler, Roisin McManus, Christina Ising, Sandra Roske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Gorss, Christoph Laske, Matthias H. Munk, Emrah Duzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka
Summary: This study investigated the potential use of experimental inflammation markers in serum for Alzheimer's disease (AD) research. The findings suggest that serum soluble AXL, IL-6, and YKL-40 are associated with AD pathology features, indicating that peripheral blood markers may correspond to specific stages of the disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.