期刊
CYTOKINE
卷 51, 期 3, 页码 240-244出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2010.06.008
关键词
Polycystic ovary syndrome; Atherosclerosis; Inflammation; Abdominal adiposity; Androgens
资金
- National Institutes of Health [HD-048535]
Women with polycystic ovary syndrome (PCOS) have chronic low level inflammation which can increase the risk of atherogenesis. We evaluated the status of circulating macrophage migration inhibitory factor (MIF), a proinflammatory cytokine involved in atherogenesis, in women with PCOS and weight-matched controls. Two-way analysis of variance models adjusted for age were fit to evaluate the effect of PCOS status (PCOS vs. controls) and weight-class (obese vs. lean) on MIF and other parameters. MIF levels were significantly (p < 0.001) higher in women with PCOS (lean: 37.7 +/- 10.6 ng/ml; obese: 54.6 +/- 15.2 ng/ml) compared to controls (lean: 4.8 +/- 0.6 ng/ml; obese: 17.5 +/- 8.0 ng/ml) regardless of weight-class. CRP levels were significantly (p < 0.001) higher in obese subjects (PCOS: 6.2 +/- 1.9 mg/l; controls: 6.7 +/- 1.4 mg/l) compared to lean subjects (PCOS: 0.9 +/- 0.4 mg/l; controls: 0.2 +/- 01 mg/l) after controlling for PCOS status. MIF levels directly correlated with % truncal fat (r = 0.41, p < 0.05), and plasma levels of CRP (r = 0.42, p = 0.05), LH (r = 0.45, p = 0.04), testosterone (r = 0.53, p < 0.008), androstendione (r = 0.58, p < 0.005). ISOGTT inversely correlated with plasma levels of MIF (r = -0.51, p < 0.02) and CRP (r = -0.73, p < 0.001). Circulating MIF is elevated in PCOS independent of obesity, but both PCOS and obesity contribute to a proatherogenic state. In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis. (C) 2010 Elsevier Ltd. All rights reserved.
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