Article
Pharmacology & Pharmacy
Shuang Wang, Juan Li, Yingjuan He, Yonghong Ran, Binghui Lu, Jining Gao, Chang Shu, Jie Li, Yazhen Zhao, Xin Zhang, Yuhui Hao
Summary: The study found that MET/PLGANPS had a better therapeutic effect on RILI than MET, alleviating RILI by inhibiting the miR-21/TGF-beta 1/Smad3 pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Immunology
Ren Jing, Sheng He, Xiao-ting Liao, Xian-long Xie, Jian-lan Mo, Zhao-kun Hu, Hui-jun Dai, Ling-hui Pan
Summary: The study found that TGF-beta 1 plays an important regulatory role in ventilator-induced lung injury, reducing inflammation and lung injury through immune function regulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Joshua M. Peterson, Jayson W. Jay, Ye Wang, Alejandro A. Joglar, Anesh Prasai, Alen Palackic, Steven E. Wolf, Amina El Ayadi
Summary: Galunisertib, an inhibitor of ALK5, has anti-fibrotic effects on dermal fibroblasts and enhances in vitro wound closure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Claude J. Rogers, Espoir M. Kyubwa, Agnes Lukaszewicz, Mark A. Starbird, Michelle Nguyen, Ben T. Copeland, Jason Yamada-Hanff, Naresh Menon
Summary: In an urban setting, a radiological/nuclear incident can result in diverse radiation-induced injuries. Acute radiation syndrome (ARS) may lead to death, while partialbody shielding can reduce the occurrence of hematopoietic ARS (H-ARS). Delayed effects of acute radiation exposure can still occur.
RADIATION RESEARCH
(2021)
Article
Plant Sciences
Ji-hong Yuan, Yu Ma, Ling-hong Yuan, Jing-jing Gong, Ling-li Xu, Lv Wang, Yong-mei Jin
Summary: This study investigates whether baicalein can attenuate lung fibrosis by regulating lung fibroblast senescence. The results suggest that baicalein can mitigate lung fibrosis, fibroblast senescence, and activation of the TGF-beta 1/Smad signaling pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Oncology
Hyun-Wook Lee, Cynthia C. Jose, Suresh Cuddapah
Summary: Nickel compounds, prevalent in the atmosphere due to industrial processes and fossil fuel burning, are associated with chronic inflammatory lung diseases, including asthma and lung cancer, primarily through the mechanism of epithelial-mesenchymal transition (EMT).
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Cell Biology
Weerachai Singhatanadgit, Irwin Olsen, Anne Young
Summary: This study investigated the direct interaction between T lymphocytes and osteoblasts and its impact on osteoblast functions and mineralization. The results showed that direct contact between the two cell types increased hydroxyapatite precipitation and enhanced mineralization. The direct cell contact also regulated the expression levels of intercellular adhesion molecule (ICAM)-1 and transforming growth factor (TGF)-beta 1 in osteoblasts. The study suggests that T lymphocytes may play a crucial role in enhancing matrix mineralization during the repair process in vivo, making ICAM-1/TGF-beta 1 potential therapeutic targets for inflammation-associated mineralized tissue diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hilary R. Keller, Davinna L. Ligons, Can Li, SuJin Hwang, Megan A. Luckey, Praveen Prakhar, Nurcin Liman, Assiatu Crossman, Vanja Lazarevic, Yoo Kyoung Park, Jung-Hyun Park
Summary: The regulatory mechanism of CD103 expression differs between CD4 and CD8 T cells, with the transcription factor Runx3 playing an important but non-essential role. Integrin beta 7 availability is crucial for CD103 surface expression, and forced CD103 expression impairs the generation of MHC-II-restricted TCR transgenic T cells. Overexpression of CD103 does not significantly affect CD4 T cells in peripheral tissues, suggesting they may use CD103-independent pathways for tissue retention.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma, Baolin Qu
Summary: GSTP1, an isoenzyme in the glutathione-S transferases enzyme system, is closely associated with the risk of radiation induced lung injury (RILI) development. It may play a role in RILI by regulating cell oxidative stress, inhibiting cell apoptosis, and promoting cytotoxic metabolism.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Wei Cheng, Hao-Long Li, Shao-Yan Xi, Xiao-Feng Zhang, Yun Zhu, Le Xing, Yan-Xuan Mo, Mei-Mei Li, Fan-En Kong, Wen-Jie Zhu, Xiao-Gang Chen, Hui-Qing Cui, Zhi-Ming Cao, Yuan-Feng Gong, Yun-Qiang Tang, Yan Zhang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu
Summary: This study demonstrates that the overexpression of GDF1 protein in poorly differentiated hepatocellular carcinoma is associated with tumor plasticity, inducing the reexpression of cancer testis antigens and enhancing sensitivity to immune checkpoint inhibition. Targeting GDF1-induced tumor lineage plasticity could potentially widen the therapeutic window for immune checkpoint inhibitors in HCC treatment.
NATURE COMMUNICATIONS
(2021)
Article
Biophysics
Li Shen, Shiyan Fu, Yonglai Chen, Wenrun Li, Suiyi Liu, Zhi Li, Jie Li, Yong Li, Yonghong Ran, Jing Zhang, Lu Qiao, Yuhui Hao
Summary: This study synthesized mannosylated polydopamine nanoparticles (MPDA NPs) to treat radiation-induced pulmonary fibrosis (RIPF) through aerosol delivery. MPDA NPs showed higher efficiency in penetrating mucus, cellular uptake, and ROS-scavenging in vitro compared to original polydopamine nanoparticles (PDA NPs). In RIPF mice, inhalation of MPDA NPs significantly alleviated inflammation, collagen deposition, and fibrosis by inhibiting the TGF-beta 1/Smad3 signaling pathway.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Cell Biology
Yulia Epshtein, Biji Mathew, Weiguo Chen, Jeffrey R. Jacobson
Summary: This study reveals the role of UCHL1 in regulating SphK1 ubiquitination and its impact on radiation-induced lung injury. Inhibition of UCHL1 reduces the ubiquitination of SphK1 and attenuates EC barrier enhancement, resulting in exacerbated RILI severity. These findings suggest a potential therapeutic strategy for RILI by modulating UCHL1 and sphingolipid signaling.
Review
Immunology
Zengfu Zhang, Jialin Zhou, Vivek Verma, Xu Liu, Meng Wu, Jinming Yu, Dawei Chen
Summary: Radiation-induced lung injury (RILI) and immunotherapy-related lung injury (IRLI) are two common complications in cancer treatment, with potential downstream pathway of pyroptosis identified as a crucial signaling pathway in lung injury treatment. More research is needed to fully understand the underlying mechanisms and signaling pathways of these complications to explore potential therapeutic targets and avenues for further research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xinglong Liu, Chunlin Shao, Jiamei Fu
Summary: RILI is a major dose-limiting side effect in thoracic cancer patients during radiotherapy, with no reliable predictors or accurate risk models currently available. Early diagnosis is crucial to overcome this issue, and the development of integrated models and further prospective research are encouraged.
Review
Dentistry, Oral Surgery & Medicine
D. M. Winn, Y-C A. Lee, M. Hashibe, P. Boffetta
Article
Oncology
Chamberlain Mbah, Hubert Thierens, Olivier Thas, Jan De Neve, Jenny Chang-Claude, Petra Seibold, Akke Botma, Catharine West, Kim De Ruyck
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2016)
Article
Oncology
Andrew Warner, Max Dahele, Bo Hu, David A. Palma, Suresh Senan, Cary Oberije, Kayoko Tsujino, Marta Moreno-Jimenez, Tae Hyun Kim, Lawrence B. Marks, Ramesh Rengan, Luigi De Petris, Sara Ramella, Kim De Ruyck, Nuria Rodriguez De Dios, Jeffrey D. Bradley, George Rodrigues
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2016)
Article
Oncology
Ludovic D'hulst, Daniel Nicolaij, Laurence Beels, Olivier Gheysens, Herwig Alaerts, Christophe Van de Wiele, Alex Maes
JOURNAL OF THORACIC ONCOLOGY
(2016)
Article
Engineering, Biomedical
Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele, Hans Pottel
PHYSICS IN MEDICINE AND BIOLOGY
(2016)
Article
Oncology
Christian Nicolaj Andreassen, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Dirk De Ruysscher, Jamie A. Cesaretti, Gillian C. Barnett, Alison M. Dunning, Leila Dorling, Catharine M. L. West, Neil G. Burnet, Rebecca Elliott, Charlotte Coles, Emma Hall, Laura Fachal, Ana Vega, Antonio Gomez-Caamano, Christopher J. Talbot, R. Paul Symonds, Kim De Ruyck, Hubert Thierens, Piet Ost, Jenny Chang-Claude, Petra Seibold, Odilia Popanda, Marie Overgaard, David Dearnaley, Matthew R. Sydes, David Azria, Christine Anne Koch, Matthew Parliament, Michael Blackshaw, Michael Sia, Maria J. Fuentes-Raspall, Teresa Ramon y Cajal, Agustin Barnadas, Danny Vesprini, Sara Gutierrez-Enriquez, Meritxell Molla, Orland Diez, John R. Yarnold, Jens Overgaard, Soren M. Bentzen, Jan Alsner
RADIOTHERAPY AND ONCOLOGY
(2016)
Article
Multidisciplinary Sciences
Amit Sud, Hauke Thomsen, Philip J. Law, Asta Foersti, Miguel Inacio da Silva Filho, Amy Holroyd, Peter Broderick, Giulia Orlando, Oleg Lenive, Lauren Wright, Rosie Cooke, Douglas Easton, Paul Pharoah, Alison Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Per Hoffmann, Markus M. Noethen, Karl-Heinz Joeckel, Elke Pogge von Strandmann, Tracy Lightfoot, Eleanor Kane, Eve Roman, Annette Lake, Dorothy Montgomery, Ruth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S. Houlston
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Chamberlain Mbah, Kim De Ruyck, Silke De Schrijver, Charlotte De Sutter, Kimberly Schiettecatte, Chris Monten, Leen Paelinck, Wilfried De Neve, Hubert Thierens, Catharine West, Gustavo Amorim, Olivier Thas, Liv Veldeman
Article
Genetics & Heredity
Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt, Sara Benlloch, Mahbubl Ahmed, Edward J. Saunders, Tokhir Dadaev, Daniel Leongamornlert, Ezequiel Anokian, Clara Cieza-Borrella, Chee Goh, Mark N. Brook, Xin Sheng, Laura Fachal, Joe Dennis, Jonathan Tyrer, Kenneth Muir, Artitaya Lophatananon, Victoria L. Stevens, Susan M. Gapstur, Brian D. Carter, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail P. Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordstrom, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo L. J. Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Hakansson, Catharine M. L. West, Alison M. Dunning, Neil Burnet, Lorelei A. Mucci, Edward Giovannucci, Gerald L. Andriole, Olivier Cussenot, Geraldine Cancel-Tassin, Stella Koutros, Laura E. Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Maehle, Eli Marie Grindedal, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Ruth C. Travis, Tim J. Key, Robert J. Hamilton, Neil E. Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C. Stern, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Liesel M. FitzGerald, Adam S. Kibel, Bettina F. Drake, Ana Vega, Antonio Gomez-Caamano, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castano-Vinyals, Kathryn L. Penney, Meir Stampfer, Jong Y. Park, Thomas A. Sellers, Hui-Yi Lin, Janet L. Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A. Ostrander, Milan S. Geybels, Borge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Rasmus Bisbjerg, Martin Andreas Roder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J. Logothetis, Esther M. John, Manuel R. Teixeira, Paula Paulo, Marta Cardoso, Susan L. Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W. Lin, Lisa F. Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Sandeep Singhal, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A. Townsend, Claire Aukim-Hastie, Manuela Gago Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J. Roobol, Guido Jenster, Ron H. N. van Schaik, Florence Menegaux, Therese Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J. Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N. Kolonel, Loic Le Marchand, Robert N. Hoover, Mitchell J. Machiela, Zuxi Cui, Peter Kraft, David V. Conti, Douglas F. Easton, Fredrik Wiklund, Stephen J. Chanock, Brian E. Henderson, Zsofia Kote-Jarai, Christopher A. Haiman, Rosalind A. Eeles
Article
Multidisciplinary Sciences
Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J. Law, Rajiv Kumar, James M. Allan, Christine J. Harrison, Anthony V. Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E. Kinsey, Eamonn Sheridan, Pamela D. Thompson, Julie A. Irving, Rolf Koehler, Per Hoffmann, Markus M. Noethen, Stefanie Heilmann-Heimbach, Karl-Heinz Joeckel, Douglas F. Easton, Paul D. P. Pharaoh, Alison M. Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A. Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Mel Greaves, Martin Zimmerman, Claus R. Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki, Richard S. Houlston
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Evi Mampaey, Annelies Fieuw, Thalia Van Laethem, Liesbeth Ferdinande, Kathleen Claes, Wim Ceelen, Yves Van Nieuwenhove, Piet Pattyn, Marc De Man, Kim De Ruyck, Nadine Van Roy, Karen Geboes, Stephanie Laurent
Article
Biochemical Research Methods
Miguel Roncoroni, Bert Droesbeke, Ignacio Eguinoa, Kim De Ruyck, Flora D'Anna, Dilmurat Yusuf, Bjoern Gruening, Rolf Backofen, Frederik Coppens
Summary: This work introduces a tool for submitting raw sequencing reads of SARS-CoV-2 to the European Nucleotide Archive, featuring a user-friendly interface, streamlined submission process, and the ability to remove human reads before submission. Additionally, a Galaxy wrap of the tool enables bulk sequencing read submissions for users with limited bioinformatics knowledge. The tool is also packaged in a Docker container for easier deployment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Gwenny Verfaillie, Caro Franck, An De Crop, Laurence Beels, Yves D'Asseler, Klaus Bacher
Summary: This systematic review and meta-analysis provides an overview of CT dose values and national DRLs for PET/CT and SPECT/CT examinations. The results show a large variation in CT dose values and the need for optimisation in hybrid imaging and implementation of nuclear medicine specific DRLs.
Review
Radiology, Nuclear Medicine & Medical Imaging
Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele, Olivier Gheysens, Hans Pottel
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joke Devriese, Laurence Beels, Christophe Van de Wiele, Alex Maes, Olivier Gheysens, Hans Pottel
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2016)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
