Article
Food Science & Technology
Chunhua Yang, Jierui Zhu, Jing Bai, Jie Zhang, Zhihua Wu, Xin Li, Ping Tong, Hongbing Chen, Anshu Yang
Summary: In the early stage of this study, three strains of Lactobacillus (Lactobacillus acidophilus CICC 6081, Lactobacillus delbrueckii subsp. Bulgaricus CICC 6103, and Lactobacillus plantarum subsp. Plantarum CICC 20988) with anti-soybean allergy potential were screened. The aim of the study was to analyze the desensitization effect of these strains on soybean-allergic mice by examining immune cell differentiation in intestinal lymph nodes and changes in gut microbiota. The results showed that the Lactobacillus strains stimulated dendritic cell proliferation and regulated Th1/Th2 differentiation balance in the MLNs and PPs of soybean-allergic mice. The Lactobacillus treatment also reversed the changes in gut microbiota observed in allergic mice.
Article
Food Science & Technology
Pilar Rodriguez-Viso, Adrian Domene, Dinoraz Velez, Vicenta Devesa, Manuel Zuniga, Vicente Monedero
Summary: A bicameral model consisting of intestinal epithelial cells (Caco-2 and HT29-MTX) and macrophages (THP-1-derived) was used to study the protective effects of two strains of Lactobacillus against mercury-induced damage. Exposure to mercury for seven days resulted in inflammation, oxidative stress, impaired intestinal barrier, and reduced wound healing capacity. However, the presence of heat-killed Lactobacillus cells during mercury exposure reversed these effects. The binding of mercury by the lactobacilli suggests a mechanism of sequestration that counteracted mercury toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Linlin Wang, Mao Chai, Jialiang Wang, Qiangqing Yu, Gang Wang, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: This study found that Bifidobacterium longum can relieve constipation by regulating the intestinal barrier, enhancing intestinal motility, improving water and electrolyte metabolism, inhibiting inflammation, and preventing loperamide-induced intestinal barrier damage.
Article
Veterinary Sciences
Hang Zhang, Minjuan Wang, Junpeng Jia, Jiayi Zhao, Stoffel Matjeke Radebe, Qinghua Yu
Summary: This study demonstrated the effectiveness of Enterococcus faecium YQH2 in preventing Salmonella typhimurium infection in chickens, showcasing its potential protective mechanism and future applications in chicken health breeding.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Yushan Bu, Yisuo Liu, Tai Zhang, Yinxue Liu, Zhe Zhang, Huaxi Yi
Summary: Bacteriocins production is an important characteristic of probiotics, which can inhibit intestinal pathogens and regulate intestinal flora. In this study, orally administering bacteriocin-producing Lactiplantibacillus plantarum YRL45 to mice resulted in enhanced immune regulation system, maintenance of colon tissue morphology without inflammation, and increased expression of genes related to intestinal barrier function. Additionally, YRL45 supplementation increased the levels of immunoglobulins and beneficial bacteria while reducing pathogenic bacteria in the intestine of mice. These findings suggest that YRL45 has the potential to be developed as a novel probiotic to enhance intestinal immunity and balance intestinal flora.
Article
Microbiology
Amel Taibi, Tomas Tokar, Julien Tremblay, Giorgio Gargari, Catherine J. Streutker, Bo Li, Agostino Pierro, Simone Guglielmetti, Thomas A. Tompkins, Igor Jurisica, Elena M. Comelli
Summary: The gut microbiota affects intestinal microRNA (miRNA) signatures and is modified by host-derived luminal miRNA. This suggests the existence of close miRNA-microbiota relationships that are critical to intestinal homeostasis. However, an integrative analysis of these relationships and their evolution during intestinal postnatal maturation is lacking.
Article
Gastroenterology & Hepatology
Christina Stene, Andrada Rome, Ingrid Palmquist, Caroline Linninge, Goran Molin, Siv Ahrne, Louis Banka Johnson, Bengt Jeppsson
Summary: Administration of probiotic strains Lp299 and CURE21 orally can reduce both systemic and local inflammatory responses in healthy individuals by lowering leukocyte counts and IL-6 levels in rectal mucosa. These findings suggest that probiotics may play an important role in reducing inflammatory responses expected after trauma during surgery or pelvic irradiation.
BMC GASTROENTEROLOGY
(2022)
Article
Immunology
Ying Liu, Feifei Fang, Yilin Xiong, Jiandi Wu, Xueyan Li, Gangping Li, Tao Bai, Xiaohua Hou, Jun Song
Summary: This study explores the effect of Piezo1 in goblet cells on the mucus layer and microbiota in the colon. The results show that Piezo1 knockout leads to decreased goblet cell numbers, thinner mucus layer, and increased inflammatory cytokines. Additionally, the diversity and richness of mucosa-associated microbiota increase, while that of fecal-associated microbiota decrease. Potentially pathogenic bacteria also show increased abundance in the inner mucus layer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Jiaying Wen, Shengwei Chen, Minglong Bao, Canying Hu, Lianyun Wu, Yanhong Yong, Xiaoxi Liu, Youquan Li, Zhichao Yu, Xingbin Ma, Jong-Bang Eun, Jae-Han Shim, Mohamad Warda, A. M. Abd, Xianghong Ju
Summary: This study investigated the mechanism of intestinal transport of COS and identified Slc9a1 as a critical molecule involved in this process. The findings provide valuable insights for improving the absorption efficiency of COS as a drug adjuvant.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Salah Edden Amini, Sophie Emilie Bresson, Jerome Ruzzin
Summary: This study demonstrates that specific deletion of Nr1i2 in the intestinal epithelium does not cause major intestinal damages in mice during both steady-state and inflammatory conditions. The role of Nr1i2 in intestinal homeostasis and inflammation needs further investigation.
Article
Biochemistry & Molecular Biology
Salah Edden Amini, Sophie Emilie Bresson, Jerome Ruzzin
Summary: Nr1i2, a nuclear receptor known for its role in xenobiotic detoxification, may also regulate intestinal homeostasis and inflammation. In this study, researchers generated intestinal epithelial-specific Nr1i2 knockout mice and found that the deletion of Nr1i2 in the intestine did not cause major damages during steady-state and inflammatory conditions. The expression of genes involved in inflammation, tight and adherens junctions, proliferation, glucose, and lipid metabolism was comparable between the knockout mice and control mice.
Article
Microbiology
Kanwal Aziz, Arsalan Zaidi, Nadeem Rehman
Summary: The present study aimed to isolate bifidobacterial probiotics and characterize the diversity of mucosal bacteria in the human distal gut using 16S rRNA amplicon sequencing. The obtained bifidobacterial strains were analyzed for biofilms and probiotic properties. Both culture-dependent and culture-independent methods revealed a significant microbial diversity. Bifidobacterium strains formed strong biofilms primarily composed of exopolysaccharides and eDNA matrix. Interactions between different strains varied, with B. bifidum showing exclusively inductive interactions. Additionally, dual species biofilms displayed a predominance of inductive interactions between B. adolescentis, B. thermophilum, B. bifidum, and B. longum. Strong biofilm-forming strains also showed antimicrobial activity and cholesterol removal ability. None of the strains exhibited harmful enzymatic activities. Understanding the interactions and functionality of biofilm-forming bifidobacterial strains is important for their utilization in human health and food or medicine applications.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Surgery
Miao Xu, Yong Yang, Qi-Wen Deng, Jian-Tong Shen, Wei-Feng Liu, Wen-Jing Yang, Ke-Xuan Liu
Summary: This study identified the expression patterns of lncRNAs and mRNAs in mouse intestinal mucosa after intestinal I/R, and predicted their potential functions and pathways. AK089510 was identified as a novel lncRNA involved in the apoptosis of intestinal mucosa, advancing the understanding of the molecular mechanisms of intestinal I/R injury.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Engineering, Chemical
Gabriela Krausova, Iveta Hynstova, Roman Svejstil, Iva Mrvikova, Robert Kadlec
Summary: The study found that commercial prebiotics and HMOs have an impact on the adhesion of the cariogenic Bifidobacterium, and Vivinal(R) seems to be a promising prebiotic to be used in the formulation of synbiotics.
Article
Multidisciplinary Sciences
Pablo Castro-Cordova, Maria Jose Mendoza-Leon, Daniel Paredes-Sabja
Summary: In elderly mice, the internalization of Clostridioides difficile spores in the ileum and colonic mucosa is higher compared to adults or young mice, while spore adherence to the ileum and colonic mucosa decreases with aging.
Article
Biochemistry & Molecular Biology
M. Di Cristofano, A. Ferramosca, M. Di Giacomo, C. Fusco, F. Boscaino, D. Luongo, Vera Rotondi Aufiero, F. Maurano, E. Cocca, G. Mazzarella, V Zara, M. Rossi, P. Bergamo
Summary: The study revealed the involvement of NOX1 and NOX2 in the eustress conditions elicited by low dose CLA, as well as the negative association of different CLA doses with the Nrf2/PGC-1α axis, providing new insight into the mechanisms underlying the hormetic effect triggered by this Nrf2 ligand.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Microbiology
Anella Saggese, Ylenia De Luca, Loredana Baccigalupi, Ezio Ricca
Summary: The study found that the antimicrobial peptide produced by Bacillus pumilus shows high specificity and antimicrobial activity against Listeria monocytogenes, and remains stable under different conditions. The synthesis and secretion time of this peptide are different from other antimicrobials, suggesting its potential biotechnological applications.
Article
Food Science & Technology
Vera Rotondi Aufiero, Luigia Di Stasio, Francesco Maurano, Francesca Accardo, Pasquale Ferranti, Gianfranco Mamone, Mauro Rossi, Giuseppe Mazzarella
Summary: The study showed that the Hammurabi wheat cultivar had a protective effect against diabetes onset in NOD mice and reduced insulitis score. In addition, the post-digestion resistant starch content of Hammurabi pasta was significantly higher compared to durum wheat pasta.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Simona Petrelli, Maria Buglione, Valeria Maselli, Claudia Troiano, Greger Larson, Laurent Frantz, Aurelie Manin, Ezio Ricca, Loredana Baccigalupi, Dominic Wright, Christian Pietri, Domenico Fulgione
Summary: Domestication and subsequent feralisation lead to the emergence of populations with a combination of wild and human-selected traits. Feral pigs exhibit distinct genetic signatures, responses to natural selection, and features reacquired from their wild ancestors. These findings suggest that feral pigs are an independent evolutionary unit capable of persisting in natural environments with minimal human intervention.
Article
Microbiology
Giovanni Di Gregorio Barletta, Maria Vittoria, Mariamichela Lanzilli, Claudia Petrillo, Ezio Ricca, Rachele Isticato
Summary: Bacterial spores of the Bacillus genus are widely distributed and can grow/sporulate in different conditions. The temperature and sporulation process in Bacillus subtilis affect the structure of spore surface, in which the CotH kinase plays a crucial role by controlling the phosphorylation levels of CotG protein, thereby regulating the assembly of other coat components.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Immunology
Lucia Treppiccione, Diomira Luongo, Francesco Maurano, Mauro Rossi
Summary: Celiac disease is a genetically predisposed autoimmune disease with a rising prevalence worldwide. The management of celiac disease requires a gluten-free diet, but there are concerns about the nutritional quality of gluten-free products. CD4(+)T cell-mediated immunity plays a central role in the pathogenesis of celiac disease.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Lucia Treppiccione, Antonio Picarelli, Mauro Rossi
Summary: Coeliac disease is caused by intolerance to wheat gluten and related proteins, and the development of gluten-free products requires technological improvements. The use of microbial transglutaminase (mTG) has been suggested as a way to replace gluten in bakery products, but concerns have been raised about its immunogenicity. Recent studies found that mTG and gliadin can interact in the endoplasmic reticulum of enterocytes in coeliac disease patients. Although the pathogenic activity of mTG has not been found, its use has been shown to reduce the inflammatory immune response in coeliac disease.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
R. Cuciniello, D. Luongo, A. Ferramosca, P. Lunetti, V. Rotondi-Aufiero, S. Crispi, V. Zara, F. Maurano, S. Filosa, P. Bergamo
Summary: Mitochondrial dysfunction, Nrf2 alteration, inflammation, and AChE hyperactivation can occur due to aluminum intake. CLA can reduce the toxic effects induced by aluminum through the activation of an adaptive response and increase glucose transporter levels, highlighting its potential for treating multifactorial diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Microbiology
Anella Saggese, Giovanni Di Gregorio Barletta, Maria Vittoria, Giuliana Donadio, Rachele Isticato, Loredana Baccigalupi, Ezio Ricca
Summary: The CotG protein in the Bacillus subtilis spore coat controls spore permeability through its central region of positively charged tandem repeats. The presence of central repeats is a common feature in CotG-like proteins in most Bacillus species. This study contributes to the understanding of the structure and function of bacterial spores.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anella Saggese, Loredana Baccigalupi, Giuliana Donadio, Ezio Ricca, Rachele Isticato
Summary: The development of efficient mucosal vaccines relies on appropriate vectors. The bacterial spore has been proposed as a vaccine delivery system, displaying antigens on its surface and inducing specific immune responses in animals. The advantages and drawbacks of using the spore and different approaches to display antigens are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lucia Treppiccione, Francesco Maurano, Stefano Rossi, Diomira Luongo, Mauro Rossi
Summary: Transamidated gliadin can modulate the inflammatory response induced by wheat gliadin in the small intestine of DQ8 mice by regulating both innate and adaptive mechanisms.
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
