Article
Oncology
Leo Yamada, Motonobu Saito, Aung Kyi Thar Min, Katsuharu Saito, Mai Ashizawa, Koji Kase, Shotaro Nakajima, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Koji Kono
Summary: EZH2 inhibitors show selective sensitivity against ARID1A-deficient GC cells, potentially affecting cell survival and proliferation by modulating the PI3K/AKT signaling pathway. This suggests the potential efficacy of targeted therapy using EZH2 inhibitors in ARID1A-deficient GC.
Article
Endocrinology & Metabolism
Sakib Hossain, Ankit Gilani, Jonathan Pascale, Elizabeth Villegas, Danielle Diegisser, Kevin Agostinucci, Melissa-Maria Kulaprathazhe, Ercument Dirice, Victor Garcia, Michal Laniado Schwartzman
Summary: GPR75 acts as the receptor for 20-HETE and overproduction of 20-HETE leads to insulin resistance in mice fed a high-fat diet. Loss-of-function variants of GPR75 have been associated with protection against obesity in a large-scale exome sequencing study.
Article
Immunology
Iva Splichalova, Jana Balounova, Matous Voboril, Tomas Brabec, Radislav Sedlacek, Dominik Filipp
Summary: Early embryonic hematopoiesis in mammals involves three successive waves of hematopoietic progenitors, with TLR2 and c-kit serving as signature markers for the second wave of erythro-myeloid precursors (EMPs). Using a novel transgenic mouse model, researchers demonstrated that targeted depletion of TLR2(+) EMPs results in a significant decrease in both erythroid and myeloid lineages, leading to embryonic lethality before E13.5, highlighting the importance of EMPs in embryonic development.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Anke Hermann, Guangming Wu, Pavel I. Nedvetsky, Viktoria C. Bruecher, Charlotte Egbring, Jakob Bonse, Verena Hoeffken, Dirk Oliver Wennmann, Matthias Marks, Michael P. Krahn, Hans Schoeler, Peter Heiduschka, Hermann Pavenstaedt, Joachim Kremerskothen
Summary: The WWC protein family regulates cell differentiation, proliferation, and organ growth via the Hippo signaling pathway. Specifically, WWC2 plays a crucial role in early embryonic development and vascularization in mice, with its deletion leading to growth retardation and embryonic lethality.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jeyoung Bang, Minguk Han, Tack-Jin Yoo, Lu Qiao, Jisu Jung, Jiwoon Na, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield, Jin-Hong Kim, Lark Kyun Kim, Byeong Jae Lee
Summary: SEPHS1 deficiency causes a gradual increase in oxidative stress, which alters signaling pathways during gastrulation and ultimately leads to apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhangqi Xu, Min Liu, Cheng Gao, Wenjun Kuang, Xiying Chen, Feifei Liu, Bai Ge, Xiaoyi Yan, Tianhua Zhou, Shanshan Xie
Summary: Deletion of the For20 gene results in embryonic growth arrest and lethality, impaired left-right patterning, reduced cilia, and disrupted angiogenesis in mammals, highlighting a critical role of For20 in early embryonic development.
Article
Pharmacology & Pharmacy
Congyun Jin, Yoshihiro Matsui, Atsushi Yonezawa, Satoshi Imai, Takashi Ogihara, Kotaro Itohara, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara
Summary: Riboflavin transporter 2 (RFVT2) plays a crucial role in cellular growth and function, and mutations have been associated with a rare neurological disorder. Deficiency in the Slc52a2 gene may lead to early embryonic lethality, indicating the essential role of RFVT2 in growth and development.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Helena Rodriguez-Caro, Aimee Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B. Sparrow
Summary: Congenital heart disease is a common human birth defect with many cases potentially caused by maternal iron deficiency, which can be prevented by iron administration in early pregnancy. Genetic predisposition and environmental factors may interact to impact the development of heart disease.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Qinghai Tan, Gabriella Stefano, Xinjie Tan, Xiu Renjie, Dorothee Roemermann, Steven R. Talbot, Ursula E. Seidler
Summary: Linaclotide, lubiprostone and tenapanor can reduce fluid absorption and increase alkaline output in the CF gut, potentially ameliorating constipation and reducing obstructive episodes in CF patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Developmental Biology
Seul Gi Park, Eun-Kyoung Kim, Ki-Hoan Nam, Jong Geol Lee, In-Jeoung Baek, Beom Jun Lee, Sang-Yoon Nam
Summary: Asb2, ankyrin repeat, and SOCS box protein 2 form an E3 ubiquitin ligase complex. Asb2 ubiquitin ligase activity drives the degradation of filamins, which are essential for humans. Knockout of Asb2 results in placental defects, affecting embryonic development and leading to early mortality.
CELLS & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Atsushi Sato, Yasunaga Shiraishi, Toyokazu Kimura, Ayumu Osaki, Kazuki Kagami, Yasuo Ido, Takeshi Adachi
Summary: In this study, the effects of SOD1 deficiency on the pathogenesis of Mets were investigated. The results showed that SOD1 deficiency led to reduced body weight gain and adipose tissue size, possibly through the regulation of ATP production, insulin secretion, and insulin resistance.
Article
Immunology
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Summary: This study investigated the effects of different pneumococcal infections on atherosclerotic plaques and found that pneumonia led to an increase in plaque macrophages, but had no significant impact on plaque burden or vulnerability markers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biology
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S. Peche, Edward F. Morris, Ramkumar Narendran, Kathryn M. Pietka, Dmitri Samovski, Hei-Yong G. Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R. Goldenring, Ondrej Kuda, Eric R. Gamazon, Jason C. Mills, Nada A. Abumrad
Summary: Research on the gastric function of CD36 suggests that its absence leads to altered gland organization, increased fibronectin, and inflammatory signaling in gastric tissues in mice. Defective epithelial cell renewal and progenitor cell differentiation impairs mucosal repair, possibly due to altered lipid metabolism and fatty acid delivery. Low CD36 expression is associated with gastric diseases in humans, highlighting the importance of CD36 in gastric tissue repair.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Albert Stachura, Ishani Khanna, Piotr Krysiak, Wiktor Paskal, Pawel Wlodarski
Summary: Type II diabetes mellitus is a common disease associated with diabetic foot ulcers and impaired wound healing. Animal models are crucial in studying this field, and a leptin-deficient murine model has been widely used. This review systematically summarizes data from over 100 studies, discussing the mechanisms underlying wound healing impairment in this model and potential interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
A. Matamoros-Angles, A. Hervera, J. Soriano, E. Marti, P. Carulla, F. Llorens, M. Nuvolone, A. Aguzzi, I Ferrer, A. Gruart, J. M. Delgado-Garcia, J. A. Del Rio
Summary: Cellular prion protein plays a crucial role in synaptic function and neuronal network formation. Its absence leads to impaired learning and memory abilities and increased anxiety-like behaviors.
