Article
Chemistry, Applied
J. Jayadevi Manoranjitham, S. Sriman Narayanan
Summary: In this study, an electrochemical sensor for the determination of BHA was developed by electropolymerization of OC over MWCNTs. The POC/MWCNTs electrode showed BHA oxidation occurring at 0.27 V, with a linear detection range from 0.33 mu M to 110 mu M and a detection limit of 0.11 mu M. Amperometric determination of BHA using chronoamperometric techniques confirmed the linear relationship. The real-time analysis of sensors was validated by analyzing packed potato chips samples.
Review
Agriculture, Multidisciplinary
Xiao-Jing Zhang, Mei-ning Diao, Yin-Feng Zhang
Summary: BHA is widely used as a food additive due to its antioxidant properties, but its extensive presence in various environmental matrices and human tissues has raised concerns. Studies have shown that BHA can cause thyroid damage, metabolic disorders, neurotoxicity, and carcinogenesis. Mechanisms such as endocrine disruption, genotoxicity, energy metabolism disturbances, ROS production, signaling pathways, and calcium homeostasis imbalances are associated with the toxic effects of BHA. Finding safe and environmentally friendly alternatives to BHA should be prioritized.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Beemkumar Nagappan, Yuvarajan Devarajan, Elangovan Kariappan, Shone Biju Philip, Shivam Gautam
Summary: This study investigates the performance and emission characteristics of a biofuelled diesel engine with the addition of an antioxidant. The results show that adding the antioxidant can increase the thermal efficiency of the engine, reduce fuel consumption, and decrease nitrogen oxide emissions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Physical
Qin Xiao, Luyao Wang, Wenfang Fan, Qianfen Zhuang, Yong Wang
Summary: A ratiometric electrochemical sensor based on a polythionine/multiwalled carbon nanotube composite modified glassy carbon electrode was developed for the determination of BHA. The sensor exhibited high selectivity, reproducibility, and stability, and demonstrated satisfactory results in the analysis of BHA in edible oil samples.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Applied
Shuang Han, Yuxin Ding, Fu Teng, Aixin Yao, Qiuxue Leng
Summary: This study introduces an innovative procedure for the development of a molecularly imprinted electrochemical sensor for ultra-sensitive and specific recognition of butylated hydroxyanisole (BHA). The prepared sensor showed a wide linear range for BHA detection and had good reproducibility, stability, and excellent selectivity.
Article
Agriculture, Dairy & Animal Science
K. Adeyemi, F. Sola-Ojo, J. Ishola, M. Ahmed, M. Lawal
Summary: The study investigated the effects of Anacardium occidentale leaf powder (AOLP) supplementation in broiler diets on growth performance, caecal microbiota, blood chemistry, splenic cytokines, serum immunoglobulins, carcase, meat quality, and oxidative status. AOLP showed antimicrobial and antioxidant properties comparable to oxytetracycline and BHA in broiler diets, but further verification is needed under challenging health conditions.
BRITISH POULTRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hoda Awad Eltayeb, Leandra Stewart, Mounira Morgem, Tommie Johnson, Michael Nguyen, Kadeshia Earl, Ayodotun Sodipe, Desiree Jackson, Shodimu-Emmanuel Olufemi
Summary: Cells produce free radicals and antioxidants during cellular metabolism, but free radicals are harmful to cells while antioxidants neutralize them. This study aimed to determine if the antioxidants BHA and BHT could ameliorate the toxic effects of acrylamide and alpha-solanine in exposed BEAS-2B cells. The results showed that BHA and BHT did not protect against the synergistic toxic effects of these compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Jiali Gu, Siyao Zheng, Xiyao Huang, Qian He, Ting Sun
Summary: The study found that the binding of BHA to serum albumin occurs through static quenching, forming a relatively stable complex with hydrophobic interactions as the main binding mechanism. BHA has the capability to bind to specific sites on BSA, and the presence of other food additives weakens the binding of BHA to BSA.
Article
Chemistry, Physical
Zhenglin Liu, Qian Zhang, Xiao Zhong, Caiqin Han
Summary: The research focuses on the dynamic SERS detection of BHA on a silver nano-tripod substrate. The interaction between BHA molecules and the substrate was analyzed, and a dynamic adsorption model of BHA molecules was developed. The practicality and operability of SERS detection were improved by adjusting the detection solvent.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Green & Sustainable Science & Technology
Zahra Arab, Sara Jafarian, Hassan Karimi-Maleh, Leila Roozbeh Nasiraie, Mohammad Ahmadi
Summary: The newly fabricated sensor showed excellent performance in monitoring BHA in water and food samples, with outstanding catalytic activity and enhanced oxidation current, and acceptable recovery data.
Article
Chemistry, Analytical
Soukaina Motia, Benachir Bouchikhi, Nezha El Bari
Summary: This study presented a facile and fast synthesis approach for the development of an electrochemical sensor for BHA analysis by self-assembling chitosan with gold nanoparticles on a screen-printed carbon electrode. The molecularly imprinted polymer sensor demonstrated high sensitivity and selectivity to BHA in food samples. The sensor showed satisfactory performance in terms of detection range, detection limit, reproducibility, stability, and repeatability, making it a potential tool for food control.
Article
Food Science & Technology
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fasmon Durjava, Maryline Kouba, Marta Lopez-Alonso, Secundino Lopez Puente, Francesca Marcon, Baltasar Mayo, Alena Pechova, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Jurgen Gropp, Montserrat Anguita, Jaume Galobart, Jordi Tarres-Call, Fabiola Pizzo
Summary: The scientific opinion on the safety and efficacy of butylated hydroxy anisole (BHA) as an antioxidant in feed for cats indicates that it is well tolerated by cats at up to 150 mg/kg complete feed. Despite being a skin and eye irritant, with potential skin sensitizing effects, BHA is unlikely to pose a risk to users through inhalation exposure.
Article
Electrochemistry
Safaa Hashim Mohammed Albayati, Pervin Soylu
Summary: In this study, an electrochemical sensor was developed for the detection of butylated hydroxyanisole (BHA) in food. The sensor showed a wide linear response range, ultra-low detection limit, and excellent stability and accuracy.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Toxicology
A. Baran, S. Yildirim, A. Ghosigharehaghaji, I Bolat, E. Sulukan, S. B. Ceyhun
Summary: The study aimed to elucidate the potential toxicity mechanism caused by BHA in zebrafish embryos, revealing that exposure to BHA and TBHQ may lead to ROS-induced apoptosis. After 96 hours of exposure, positive 8-OHdG immunofluorescence, degenerative changes, and necrosis were observed in the brain of BHA and TBHQ-treated zebrafish larvae in a dose-dependent manner.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mizuki Mizobuchi, Kazumi Ishidoh, Norio Kamemura
Summary: The study investigated the cytotoxic effects of BHA and differences in cell death mechanism for BHA and BHT in rat thymocytes. The results showed that BHA induced apoptosis, while BHT induced non-apoptotic cell death in rat thymocytes.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
