Article
Cardiac & Cardiovascular Systems
Michael Spartalis, Eleftherios Spartalis, Gerasimos Siasos
Summary: Cardiac allograft vasculopathy (CAV) is a significant risk factor for the long-term survival of heart transplant recipients, and its etiology and identification remain challenging. Early diagnosis and prevention are crucial, and advancements in diagnostic techniques have provided prognostic tools and biomarkers, while pharmaceutical advancements have improved the progression of the disease.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Carmela Napolitano, Giorgia Grutter, Paola Francalanci, Antonio Amodeo, Aurelio Secinaro
Summary: Heart transplant recipients undergo postoperative screening to exclude complications. Cardiac magnetic resonance imaging is a non-invasive tool for monitoring graft health. We describe a case of a female heart transplant recipient with worsening clinical condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon Chih, Aun Yeong Chong, Vladimir Dzavik, Derek Y. Y. So, Natasha Aleksova, George A. Wells, Jordan Bernick, Christopher B. Overgaard, Ellamae Stadnick, Lisa M. Mielniczuk, Rob S. B. Beanlands, Heather J. Ross
Summary: This study aimed to determine predictors of early coronary artery disease (CAD) after heart transplantation. Heart transplant recipients were evaluated for one year for coronary anatomic-physiologic changes and the related predictors. The study found that fibrotic plaque on optical coherence tomography and index of microcirculatory resistance could predict CAD progression early posttransplant.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Article
Cardiac & Cardiovascular Systems
Madeleine Orban, Sarah Ulrich, Dominic Dischl, Patrick von Samson-Himmelstjerna, Rene Schramm, Katharina Tippmann, Ralph Hein-Rothweiler, Anna Strueven, Anja Lehner, Daniel Braun, Joerg Hausleiter, Andre Jakob, Marcus Fischer, Christian Hagl, Nikolaus Haas, Steffen Massberg, Julinda Mehilli, Dalla Pozza Robert
Summary: This study compared the development of intimal hyperplasia in pediatric and adult heart transplant patients using optical coherence tomography (OCT), showing a higher I/M ratio in children and higher absolute intima thickness in adults. Age and time seem to have an impact on the prevalence of intimal hyperplasia in intracoronary imaging.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Wen Lin, Chien-Sung Tsai, Chun-Yao Huang, Yi-Ting Tsai, Chun-Ming Shih, Shing-Jong Lin, Chi-Yuan Li, Cheng-Yen Lin, Shih-Ying Sung, Feng-Yen Lin
Summary: This study explores the feasibility of far-infrared therapy in preventing vasculopathy induced by orthotopic allograft transplantation (OAT). The results show that far-infrared therapy can effectively inhibit smooth muscle cell proliferation and reduce inflammation, leading to decreased severity of vasculopathy in OAT recipients.
Article
Surgery
Rabea Asleh, Hilmi Alnsasra, Amir Lerman, Alexandros Briasoulis, Naveen L. Pereira, Brooks S. Edwards, Takumi Toya, John M. Stulak, Alfredo L. Clavell, Richard C. Daly, Sudhir S. Kushwaha
Summary: The study found that heart transplant recipients who develop proteinuria after conversion to sirolimus have poorer baseline renal function, less attenuation of cardiac allograft vasculopathy progression, and higher risk of mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Roest, Ricardo P. J. Budde, Jasper J. Brugts, Jan von der Thusen, Theo van Walsum, Yannick J. H. J. Taverne, Felix Zijlstra, Daniel Bos, Olivier C. Manintveld
Summary: This study found that the volume of epicardial fat (EFV) is associated with the development of cardiac allograft vasculopathy (CAV) in heart transplant patients, and the recipient sex has a greater influence on EFV than the donor sex.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Ya-fei Qin, De-jun Kong, Hong Qin, Yang-lin Zhu, Guang-ming Li, Cheng-lu Sun, Yi-ming Zhao, Hong-da Wang, Jing-peng Hao, Hao Wang
Summary: This study investigated the synergistic effects of melatonin (MT) in combination with mesenchymal stromal cells (MSCs) in attenuating chronic allograft vasculopathy. The results showed that the combined therapy effectively ameliorated pathological changes, inhibited T cell proliferation, modulated immune cell populations, reduced circulating antibody levels, and decreased inflammatory cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Vera Usuelli, Moufida Ben Nasr, Francesca D'Addio, Kaifeng Liu, Andrea Vergani, Basset El Essawy, Jun Yang, Emma Assi, Mayuko Uehara, Chiara Rossi, Anna Solini, Annalisa Capobianco, Elena Rigamonti, Luciano Potena, Massimo Venturini, Mario Sabatino, Lorena Bottarelli, Enrico Ammirati, Maria Frigerio, Eduardo Castillo-Leon, Anna Maestroni, Cinzia Azzoni, Cristian Loretelli, Andy Joe Seelam, Albert K. Tai, Ida Pastore, Gabriella Becchi, Domenico Corradi, Gary A. Visner, Gian Zuccotti, Nelson B. Chau, Reza Abdi, Marcus G. Pezzolesi, Paolo Fiorina
Summary: The study found that miR-21 is overexpressed in chronic allograft vasculopathy (CAV) in both murine and human samples, and targeting miR-21 delays the onset of CAV by reprogramming macrophage metabolism.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Fay M. A. Nous, Stefan Roest, Eva D. van Dijkman, Mohamed Attrach, Kadir Caliskan, Jasper J. Brugts, Koen Nieman, Alexander Hirsch, Alina A. Constantinescu, Olivier C. Manintveld, Ricardo P. J. Budde
Summary: In this study, coronary computed tomography angiography (CCTA) was successfully implemented for the detection of cardiac allograft vasculopathy (CAV) in heart transplant patients. The CCTA showed good image quality and low radiation dose, with limited need for additional invasive testing. This suggests that CCTA is a feasible and effective method for routine assessment of CAV in heart transplant patients.
TRANSPLANT INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rabea Asleh, Alexandros Briasoulis, Byron Smith, Camden Lopez, Hilmi Alnsasra, Naveen L. Pereira, Brooks S. Edwards, Alfredo L. Clavell, John M. Stulak, Chaim Locker, Walter K. Kremers, Richard C. Daly, Amir Lerman, Sudhir S. Kushwaha
Summary: Study suggests that early use of aspirin after heart transplantation may delay CAV progression, reduce mortality, and decrease the risk of CAV-related graft dysfunction. However, it does not seem to affect the overall rate of CAV-associated events.
JOURNAL OF CARDIAC FAILURE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sharon Chih, Christiane C. Wiefels, Rob S. B. Beanlands
Summary: Heart transplantation is an effective therapy for end-stage heart disease, but Cardiac allograft vasculopathy (CAV) is a common and life-threatening complication post-transplantation. Cardiac PET shows high diagnostic accuracy for CAV and helps in patient risk stratification.
SEMINARS IN NUCLEAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Nina Fluschnik, Bastiaan Geelhoed, Peter Moritz Becher, Benedikt Schrage, Fabian J. Brunner, Dorit Knappe, Alexander M. Bernhardt, Stefan Blankenberg, Jon Kobashigawa, Hermann Reichenspurner, Renate B. Schnabel, Christina Magnussen
Summary: This study analyzed data from 40,647 heart transplant recipients and found that male sex, African American and Asian ethnicity, ischemic cardiomyopathy, overweight, and smoking are recipient risk factors associated with CAV, while older age, male sex, smoking, diabetes, and arterial hypertension are donor-related risk factors for CAV. Classical cardiovascular risk factors played a relatively minor role in the 5-year attributable risk for CAV.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)